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Meclizine Dihydrochloride Monohydrate

Meclizine Dihydrochloride Monohydrate
Meclizine Dihydrochloride Monohydrate structure
CAS No.
31884-77-2
Chemical Name:
Meclizine Dihydrochloride Monohydrate
Synonyms
Permesin;Antivert;Meclizine hydrochloride;Meclizine Related CoMpound B;MECLIZINE HYDROCHLORIDE (500 MG);MECLIZINE HYDROCHLORIDE MONOHYDRATE;Meclizine dihydrochloride monohydrate;Meclizine Dihydrochloride Monohydrate USP/EP/BP;1-[(4-Chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]piperazine DiHydrochloride Hydrate;1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine hydrate dihydrochloride
CBNumber:
CB1501443
Molecular Formula:
C25H27ClN2.2ClH.H2O
Formula Weight:
481.892
MOL File:
31884-77-2.mol

Meclizine Dihydrochloride Monohydrate Properties

Melting point:
210-213°C
storage temp. 
-20°C Freezer
Water Solubility 
Insoluble in water.
CAS DataBase Reference
31884-77-2
FDA 21 CFR
336.10
FDA UNII
HDP7W44CIO
NCI Drug Dictionary
Antivert
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Hazard statements  H302-H361
Precautionary statements  P201-P280-P301+P312a-P308+P313-P405-P501a
TSCA  Yes
HS Code  2933599550

Meclizine Dihydrochloride Monohydrate price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J62464 Meclizine dihydrochloride monohydrate 31884-77-2 1g $0 2020-06-24 Buy
Alfa Aesar J62464 Meclizine dihydrochloride monohydrate 31884-77-2 5g $0 2020-06-24 Buy
Alfa Aesar J62464 Meclizine dihydrochloride monohydrate 31884-77-2 10g $0 2020-06-24 Buy

Meclizine Dihydrochloride Monohydrate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Antivert,Roerig,US,1957

Uses

Antiemetic

Uses

Meclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

General Description

Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo.

Meclizine Dihydrochloride Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products


Meclizine Dihydrochloride Monohydrate Suppliers

Global( 64)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17505 58
Xi'an MC Biotech, Co., Ltd.
18991951683 02989275612
8618991951683 mcbio_sales@163.com CHINA 2308 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 info@dycnchem.com CHINA 52932 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132148 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Meclizine Dihydrochloride Monohydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Meclizine Dihydrochloride Monohydrate
31884-77-2
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-17 Meclizine Dihydrochloride Monohydrate USP/EP/BP
31884-77-2
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-01-08 Meclizine Dihydrochloride Monohydrate
31884-77-2
US $1.00 / KG 1KG 98%-99.9% 200KG Career Henan Chemical Co

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