WEDELOLACTONE
- CAS No.
- 524-12-9
- Chemical Name:
- WEDELOLACTONE
- Synonyms
- Wedelolactone;Wedelia lactone;Wedelolactone CRS;Wedelolactone, ≥98%(HPLC);IKK Inhibitor II, Wedelolactone;5,11,12-Trihydroxy-7-MethoxycouMestan;Wedelolactone, 98%, from Wedelia chinensis (Osbeck.) Merr.;IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem;1,8,9-trihydroxy-3-Methoxy-6H-benzofuro[3,2-c]chroMen-6-one;1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
- CBNumber:
- CB1505300
- Molecular Formula:
- C16H10O7
- Molecular Weight:
- 314.25
- MDL Number:
- MFCD07778564
- MOL File:
- 524-12-9.mol
- MSDS File:
- SDS
| Melting point | 327～330℃ |
|---|---|
| Boiling point | 498.4±45.0 °C(Predicted) |
| Density | 1.655±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 14 mg/mL, soluble |
| form | solid |
| pka | 6.90±0.20(Predicted) |
| color | brown-beige |
| InChIKey | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| FDA UNII | 0K6L725GNS |
WEDELOLACTONE price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W4016 | Wedelolactone ≥98% (HPLC), powder | 524-12-9 | 1mg | $166 | 2024-03-01 | Buy |
| TCI Chemical | W0015 | Wedelolactone | 524-12-9 | 1MG | $117 | 2024-03-01 | Buy |
| TCI Chemical | W0015 | Wedelolactone | 524-12-9 | 10MG | $525 | 2024-03-01 | Buy |
| Cayman Chemical | 11796 | Wedelolactone ≥98% | 524-12-9 | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 11796 | Wedelolactone ≥98% | 524-12-9 | 1mg | $82 | 2024-03-01 | Buy |
WEDELOLACTONE Chemical Properties,Uses,Production
Uses
Wedelolactone is inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.
Definition
ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Biological Activity
wedelolactone is an inhibitor of ikk.ikb kinase (ikk) complex contains the catalytic subunits ikkα and ikkβ, and the regulatory subunit ikkγ/nemo. ikk, is a kinase critical for activation of nf-κb by mediating phosphorylation and degradation of iκbα. the induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream nf-κb-mediated transcription[1].
Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.
in vitro
in cultured mouse balb/c 3t3 cells, mouse splenocytes and hela cells, wedelolactone (0~100 μm) inhibited lps-induced caspase-11 expression by inhibiting nf-κb-mediated transcription through the direct inhibition of ikk. wedelolactone played an potential role in anti-inflammatory therapy to inhibit il-1β levels in diseases such as rheumatoid arthritis, asthma and septic shock[1].
in vivo
on swiss albino male mouse skin, ikk inhibition by wedelolactone (10 μm) prevented the induction of nf-κb, perturbed the generation of reactive oxygen species and reactive nitrogen intermediates, blunted the signal transduction that lead to the activation of the early immediate genes, and thereby protected mouse skin from the uvb induced neoplastic transformation, angiotropism and metastatic progression [2].
References
[1] kobori m, yang z, gong d, et al. wedelolactone suppresses lps-induced caspase-11 expression by directly inhibiting the ikk complex.[j]. cell death & differentiation, 2004, 11(1):123-30.
[2] ali f, khan b a, sultana s. wedelolactone mitigates uvb induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of nfκb pathway[j]. european journal of pharmacology, 2016, 786:253-264.
WEDELOLACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from WEDELOLACTONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Wedelolactone
524-12-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-13 | wedelolactone
524-12-9
|
US $90.00 / KG | 1KG | 99% | 100mt | Hebei baicao biology science and technology co., ltd | |
 |
2021-07-20 | Wedelolactone
524-12-9
|
US $0.00-0.00 / KG | 5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Wedelolactone
524-12-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- wedelolactone
524-12-9
- US $90.00 / KG
- 99%
- Hebei baicao biology science and technology co., ltd
-
- Wedelolactone
524-12-9
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd