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Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate structure

CAS No.: 89793-12-4

Chemical Name:: Ethyl 2-chloropyrimidine-5-carboxylate

Synonyms: EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;Ethyl 2-chloropyrimidine-5-carboxylat;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-Chloro-5-pyrimidinecarboxylate ethyl ester;2-chloro-pyrimidine-5-carboxylic acid ethyl ester

CBNumber:: CB1547225

Molecular Formula:: C7H7ClN2O2

Molecular Weight:: 186.6

MDL Number:: MFCD09863164

MOL File:: 89793-12-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:07

Product description	Number	Pack Size	Price
Ethyl 2-Chloropyrimidine-5-carboxylate >98.0%(GC)	E1250	1g	$57
Ethyl2-Chlorpyrimidine-5-carboxylate	E678415	10g	$825
2-Chloro-pyrimidine-5-carboxylic acid ethyl ester 95+%	058906	100g	$845
Ethyl 2-Chloropyrimidine-5-carboxylate 96.00%	HCH0105774	1G	$934.05
Ethyl 2-Chloropyrimidine-5-carboxylate	W9257	25g	$207
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Ethyl 2-chloropyrimidine-5-carboxylate Properties

Melting point	52-60℃
Boiling point	80℃/760mm
Density	1.311±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
pka	-3.05±0.22(Predicted)
form	Solid
color	White to Light yellow
InChI	InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
InChIKey	IEMKQRSOAOPKRJ-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference	89793-12-4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

20/21/22

Safety Statements

36/37

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

Ethyl 2-chloropyrimidine-5-carboxylate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1250	Ethyl 2-Chloropyrimidine-5-carboxylate >98.0%(GC)	89793-12-4	1g	$57	2026-04-30	Buy
TRC	E678415	Ethyl2-Chlorpyrimidine-5-carboxylate	89793-12-4	10g	$825	2021-12-16	Buy
Matrix Scientific	058906	2-Chloro-pyrimidine-5-carboxylic acid ethyl ester 95+%	89793-12-4	100g	$845	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0105774	Ethyl 2-Chloropyrimidine-5-carboxylate 96.00%	89793-12-4	1G	$934.05	2021-12-16	Buy
AK Scientific	W9257	Ethyl 2-Chloropyrimidine-5-carboxylate	89793-12-4	25g	$207	2021-12-16	Buy

Product number	Packaging	Price	Buy
E1250	1g	$57	Buy
E678415	10g	$825	Buy
058906	100g	$845	Buy
HCH0105774	1G	$934.05	Buy
W9257	25g	$207	Buy

Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to light yellow liquid

Uses

Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.

Synthesis

A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).

References

[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 34
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 27; 28
[3] Patent: US2009/76006, 2009, A1. Location in patent: Page/Page column 31; 40
[4] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 138-139
[5] Patent: WO2009/36016, 2009, A1. Location in patent: Page/Page column 69

Ethyl 2-chloropyrimidine-5-carboxylate synthesis

Synthesis of Ethyl 2-chloropyrimidine-5-carboxylate from 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester

Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl potassium malonate Ethanol Ethyl 3-ethoxypropionate N,N-Dimethylformamide Ethyl formate

Toluene Sodium Phosphorus oxitrichloride Urea N,N-Dimethylaniline

Hydrochloric acid Bromine Acetic acid Dimethyl sulfate

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Preparation Products

2-Chloropyrimidine-5-carbonitrile (2-Pyrrolidin-1-ylpyrimidin-5-yl)methanol

Ethyl 2-chloropyrimidine-5-carboxylate Suppliers

Global( 246)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9540	58
Hangzhou Collab Medicine Co.,Ltd.	+8615936229464	candice@collab-med.com	China	999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58

Supplier	Advantage
Finetech Industry Limited	58
Hangzhou Collab Medicine Co.,Ltd.	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Yunbio Tech Co.,Ltd.	58

View Lastest Price from Ethyl 2-chloropyrimidine-5-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-26	Ethyl 2-chloropyrimidine-5-carboxylate 89793-12-4	US $0.00 / kg	1kg	99%HPLC;99%GC	1ton	Nanjing Fred Technology Co., Ltd
2021-07-02	ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-05-15	ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

Ethyl 2-chloropyrimidine-5-carboxylate
89793-12-4
US $0.00 / kg
99%HPLC;99%GC
Nanjing Fred Technology Co., Ltd

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Ethyl 2-chloropyrimidine-5-carboxylate Spectrum

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)¹HNMR ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)FT-IR

89793-12-4(Ethyl 2-chloropyrimidine-5-carboxylate)Related Search:

4,6-Dihydroxypyrimidine 2,5-PYRIDINEDICARBOXYLIC ACID 2-Chloropyrimidine 2-Chloropyrimidine-5-carboxylic acid ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate

BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate Ethyl 2-chloropyrimidine-5-carboxylate ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE

CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate

ethyl 2,4-dichloropyrimidine-5-carboxylate

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Ethyl 2-chloropyrimidine-5-carboxylate ,97% 2-chloro-pyrimidine-5-carboxylic acid ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine 5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine Ethyl 2-Chlorpyrimidine-5-carboxylate 2-chloro-pyriMidine-5-carboxylate ETHYL2-CHLOROPYRIMI EOS-60350 5-Pyrimidinecarboxylic acid, 2-chloro-, ethyl ester (7CI, 9CI, ACI) 2-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI) 2-Chloro-5-pyrimidinecarboxylate ethyl ester Ethyl 2-chloropyrimidine-5-carboxylat 89793-12-4 Heterocycle-Pyrimidine series