NOC-18
- CAS No.
- 146724-94-9
- Chemical Name:
- NOC-18
- Synonyms
- NOC-18;NOC 18;DETA/NO;DETA NONOATE;DETA NONOate,97%;DETA-NONOate,NOC-18;NOC 18, DETA NONOate,;DIETHYLENETRIAMINE NONOATE;NOC-18 - CAS 146724-94-9 - Calbiochem;2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHAMINE
- CBNumber:
- CB1665312
- Molecular Formula:
- C4H13N5O2
- Molecular Weight:
- 163.18
- MDL Number:
- MFCD00278808
- MOL File:
- 146724-94-9.mol
- MSDS File:
- SDS
| Melting point | 98-106 °C |
|---|---|
| Boiling point | 290.26°C (rough estimate) |
| Density | 1.3102 (rough estimate) |
| refractive index | 1.8000 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: >20 mg/mL |
| pka | 4.50±0.69(Predicted) |
| form | solid |
| color | off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored. |
| CAS DataBase Reference | 146724-94-9 |
| FDA UNII | LDS7ZYG72J |
NOC-18 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A5581 | 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene ≥95% | 146724-94-9 | 10mg | $262 | 2022-05-15 | Buy |
| Sigma-Aldrich | 487957 | NOC-18 | 146724-94-9 | 10mg | $205 | 2022-05-15 | Buy |
| Cayman Chemical | 82120 | DETA NONOate ≥98% | 146724-94-9 | 10mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 82120 | DETA NONOate ≥98% | 146724-94-9 | 50mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | D185 | Diethylenetriamine/nitric oxide adduct ≥97% (NMR), solid | 146724-94-9 | 10mg | $47.5 | 2022-05-15 | Buy |
NOC-18 Chemical Properties,Uses,Production
Description
DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
Chemical Properties
White Powder
Uses
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.
Uses
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.
Definition
ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Biochem/physiol Actions
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.
References
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
NOC-18 Preparation Products And Raw materials
Raw materials
Preparation Products
NOC-18 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17779 | 75 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15878 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2886750 13927877953 | 3005811397@qq.com | China | 13374 | 58 |
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