Tigogenin
- CAS No.
- 77-60-1
- Chemical Name:
- Tigogenin
- Synonyms
- Nsc93754;Ticogenin;TIGOGENIN;Sisalagenin;TIGOGENIN90%;Tigogenin-RM;Sisal saponin;SMILAGENIN(RG);Trigonegenin B;Tsosarsasaprgein
- CBNumber:
- CB1669512
- Molecular Formula:
- C27H44O3
- Molecular Weight:
- 416.64
- MDL Number:
- MFCD00067287
- MOL File:
- 77-60-1.mol
| Product description | Number | Pack Size | Price |
| Tigogenin phyproof? Reference Substance | PHL83916 | 10MG | $363 |
| Tigogenin | 30137 | 10mg | $44 |
| Tigogenin | 30137 | 250mg | $745 |
| Tigogenin | 30137 | 50mg | $193 |
| Tigogenin | 30137 | 100mg | $341 |
| More product size | |||
| Melting point | 202-204°C |
|---|---|
| alpha | -68 º (c=0.8g/100ml, CHCl3) |
| Boiling point | 474.91°C (rough estimate) |
| Density | 1.0362 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 15.14±0.70(Predicted) |
| color | Off-White |
| optical activity | -67.218 (c 1, CHCl3) |
| InChIKey | GMBQZIIUCVWOCD-YBQFXAOSNA-N |
| CAS DataBase Reference | 77-60-1(CAS DataBase Reference) |
| FDA UNII | 4SMU15RR44 |
| NIST Chemistry Reference | Tigogenin(77-60-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
Tigogenin price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83916 | Tigogenin phyproof? Reference Substance | 77-60-1 | 10MG | $363 | 2025-07-31 | Buy |
| Cayman Chemical | 30137 | Tigogenin | 77-60-1 | 10mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 30137 | Tigogenin | 77-60-1 | 250mg | $745 | 2024-03-01 | Buy |
| Cayman Chemical | 30137 | Tigogenin | 77-60-1 | 50mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 30137 | Tigogenin | 77-60-1 | 100mg | $341 | 2024-03-01 | Buy |
Tigogenin Chemical Properties,Uses,Production
Description
Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Chemical Properties
mp 196-208C° LOD ≤0.5%
Uses
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
Definition
ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.
References
[1] A.L. CRIPPS G. B. A quantitative gas-liquid chromatographic method for the estimation of hecogenin and tigogenin in the leaves, juice and sapogenin concentrates of agave sisalana[J]. Steroids, 1978, 31 5: Pages 661-669. DOI: 10.1016/s0039-128x(78)80006-3
[2] HUA ZHOU . Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[J]. Molecular and Cellular Endocrinology, 2007, 270 1: Pages 17-22. DOI: 10.1016/j.mce.2007.01.017
[3] SUNIL KUMAR UPADHYAY . Synthesis and antifungal activity of functionalized 2,3-spirostane isomers[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21 10: Pages 2826-2831. DOI: 10.1016/j.bmcl.2011.03.092
[4] A T PEANA. Anti-inflammatory activity of aqueous extracts and steroidal sapogenins of Agave americana.[J]. Planta medica, 1997, 63 3: 199-202. DOI: 10.1055/s-2006-957652
Tigogenin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21614 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29847 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from Tigogenin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-10 | Tigogenin
77-60-1
|
US $53.00-90.00 / mg | 99.97% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Tigogenin
77-60-1
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-02-19 | Tigogenin
77-60-1
|
US $0.00 / KG | 1KG | 97.9% | 100 tons | Honest Joy Holdings Limited
|
