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Dihydromyricetin

Dihydromyricetin
Dihydromyricetin structure
CAS No.
27200-12-0
Chemical Name:
Dihydromyricetin
Synonyms
ampeloptin;AMPELOPSIN;3,3',4',5,5;,(2r-trans)-;Ampelopsin(AMP);ampelopsin(flavanol);DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;Two hydrogenMyricetin;Dihydromyricetin (DHM)
CBNumber:
CB1670507
Molecular Formula:
C15H12O8
Formula Weight:
320.25
MOL File:
27200-12-0.mol

Dihydromyricetin Properties

storage temp. 
-20°C
solubility 
DMSO: ≥5mg/mL (warmed)
form 
powder
Boiling point:
780.7±60.0 °C(Predicted)
Density 
1.808±0.06 g/cm3(Predicted)
Melting point:
239-241 °C
pka
7.38±0.60(Predicted)
color 
white to beige
InChIKey
KJXSIXMJHKAJOD-LSDHHAIUSA-N
CAS DataBase Reference
27200-12-0
EWG's Food Scores
1
FDA UNII
KD8QND6427
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
HS Code  29329990

Dihydromyricetin price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0295 Dihydromyricetin ≥98% (HPLC) 27200-12-0 5mg $73.2 2020-08-18 Buy
Sigma-Aldrich 42866 Dihydromyricetin analytical standard 27200-12-0 10mg $155 2021-03-22 Buy
TCI Chemical D5464 Dihydromyricetin >97.0%(HPLC) 27200-12-0 200mg $158 2021-03-22 Buy
TCI Chemical D5464 Dihydromyricetin >97.0%(HPLC) 27200-12-0 1g $395 2021-03-22 Buy
Cayman Chemical 23549 Dihydromyricetin ≥98% 27200-12-0 5mg $65 2021-03-22 Buy

Dihydromyricetin Chemical Properties,Uses,Production

Description

Dihydromyricetin (DHM), also called ampelopsin, is the major flavonoid in Ampelopsis plants, primarily in the species grossedentata. It is also found in some other plant species, such as the Japanese raisin tree, Hovenia dulcis. These plants have been used as part of traditional Asian medicine, due to their reported anti-inflammatory, antioxidant, and anti-cancer properties, which have more recently been attributed to their high DHM content. DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties. In preclinical animal models, DHM shows a variety of beneficial anti-aging properties, by reducing inflammation, oxidative stress, lipidemia, as well as regulating energy metabolism and promoting autophagy. These effects are primarily derived from its ability to activate sirtuins. However, the magnitude of the benefits seen in preclinical studies has not yet translated to the effects seen in clinical trials, likely due to the poor stability and bioavailability of currently available DHM preparations.

Definition

ChEBI: An optically active form of dihydromyricetin having (2R,3R)-configuration.

Clinical Use

Dihydromyricetin (DHM) is a natural antioxidant, It is a flavonoid isolated from Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang (family Vitaceae), an edible plant used in traditional Chinese medicine (Li et al., 2017). The original herb has effects of detoxification, anti-inflammatory and analgesic, commonly used as a dietary supplement. DHM is now demonstrated to impede atherosclerotic process by regulating endothelial dysfunction(Yang D. et al.,2018),and exert anti-aging effect against neurodegenerative diseases (Kou et al.,2016).It inhibits miR-21 expression and then improves endothelial dysfunction induced by TNF- , accompanied by suppression of abnormal expression of eNOS, DDAH1, NO, and ADMA, as well as improvement of tube formation and migration. Furthermore, miR-21 blockade can produce similar effects with DHM treatment; while miR-21 overexpression abolishes the above protection. Additionally,improvement of endothelial dysfunction can be reversed by a non-specific NOs inhibitor, indicating DHM ameliorates vascular endothelial function and inhibits atherosclerosis by targeting miR-21-mediated DDAH1/ADMA/NO signal pathway(Yang D.et al., 2018).

Dihydromyricetin Preparation Products And Raw materials

Raw materials

Preparation Products


Dihydromyricetin Suppliers

Global( 308)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Aktin Chemicals, Inc.
028-85159085
86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

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View Lastest Price from Dihydromyricetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Dihydromyricetin
27200-12-0
US $8.00 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-17 Dihydromyricetin 27200-12-0
27200-12-0
US $12.50 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-11-08 Dihydromyricetin
27200-12-0
US $1.36 / g 100g 99 3000KG Wuhan wingroup Pharmaceutical Co., Ltd

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