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AICAR

adenosine regulating agents
AICAR
AICAR structure
CAS No.
2627-69-2
Chemical Name:
AICAR
Synonyms
AMPK;ICAR;AAKG;CMH6;WPWS;AICAR;AMPK1;Acair;AMPK2;AMPKb
CBNumber:
CB1675294
Molecular Formula:
C9H14N4O5
Formula Weight:
258.23
MOL File:
2627-69-2.mol

AICAR Properties

Melting point:
214-215 °C
storage temp. 
−20°C
solubility 
H2O: >10 mg/mL
form 
powder
color 
tan
Water Solubility 
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax
265nm(NaOH)(lit.)
Merck 
14,16
InChIKey
RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference
2627-69-2(CAS DataBase Reference)
EPA Substance Registry System
1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-45-53
WGK Germany  3
TSCA  Yes
HS Code  29349990
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

AICAR price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A9978 AICAR ≥98% (HPLC), powder 2627-69-2 5mg $62.8 2018-11-13 Buy
Sigma-Aldrich A9978 AICAR ≥98% (HPLC), powder 2627-69-2 25mg $217 2018-11-13 Buy
Alfa Aesar J64720 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98% 2627-69-2 200mg $265 2018-11-13 Buy
Alfa Aesar J64720 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98% 2627-69-2 50mg $110 2018-11-13 Buy
Cayman Chemical 10010241 AICAR ≥98% 2627-69-2 100mg $81 2018-11-19 Buy

AICAR Chemical Properties,Uses,Production

adenosine regulating agents

Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

Chemical Properties

Solid

Uses

glucose uptake stimulant; AMPK activator

Uses

AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Definition

ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

AICAR Preparation Products And Raw materials

Raw materials

Preparation Products


AICAR Suppliers

Global( 159)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 570 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 16534 60
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 215 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20243 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 304 58

View Lastest Price from AICAR manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-24 AICAR
2627-69-2
US $1307.00 / G 1G 99% customise career henan chemical co
2019-03-22 High quality AICAR CAS: 2627-69-2 Acadesine factory sales
2627-69-2
US $1.00 / kg 1 公斤 99% 20tons Hebei Jimi Trading Co., Ltd.
2018-05-16 AICAR
2627-69-2
US $10.00 / KG 10G 99% 1000kg Meihua Biological Technology Co.,Ltd

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