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RAUWOLSCINE HYDROCHLORIDE

RAUWOLSCINE HYDROCHLORIDE
RAUWOLSCINE HYDROCHLORIDE structure
CAS No.
6211-32-1
Chemical Name:
RAUWOLSCINE HYDROCHLORIDE
Synonyms
Nsc407307;RAUWOLSCINE;ISOYOHIMBINE;MESOYOHIMBINE;RAUWOLSCINE HCL;ALPHA-YOHIMBINE;ALPHA-YOHIMBINE HCL;YOHIMBINE HCL, ALPHA-;RAUWOLSCINE HYDROCHLORIDE;Isoyohimbine hydrochloride
CBNumber:
CB1684795
Molecular Formula:
C21H27ClN2O3
Formula Weight:
390.9
MOL File:
6211-32-1.mol

RAUWOLSCINE HYDROCHLORIDE Properties

Melting point:
270-280°C
storage temp. 
Store at RT
solubility 
H2O: soluble
form 
solid
color 
white
Sensitive 
Light Sensitive
CAS DataBase Reference
6211-32-1
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Hazard statements  H300-H310-H330
Precautionary statements  P301+P310a-P304+P340-P320-P330-P405-P501a
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  22-36/37/39-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  ZG1035000
HazardClass  6.1
HS Code  29339900

RAUWOLSCINE HYDROCHLORIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J63198 Rauwolscine hydrochloride, 99% 6211-32-1 100mg $138 2021-03-22 Buy
Cayman Chemical 15596 Rauwolscine (hydrochloride) ≥98% 6211-32-1 50mg $29 2021-03-22 Buy
Cayman Chemical 15596 Rauwolscine (hydrochloride) ≥98% 6211-32-1 100mg $55 2021-03-22 Buy
Cayman Chemical 15596 Rauwolscine (hydrochloride) ≥98% 6211-32-1 250mg $123 2021-03-22 Buy

RAUWOLSCINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

This alkaloid is isolated as the oxalate from the leaf extract of Rauwolfia canescens L. from which the free base may be obtained as colourless needles which are laevorotatory with [α]30D - 40° (EtOH). The alkaloid forms crystalline salts: the hydrochloride, m.p. 27S-2S00C (dec.); [α]30D + 74° (H20); nitrate, m.p. 257-SoC (dec.); oxalate, m.p. 245-6°C and the picrate, m.p. 20SoC. Two active hydrogens are present and the alkaloid furnishes a monoacetyl derivative, m.p. 2l6-SoC (dec.). Treatment with concentrated ammonia solution at room temperature converts the base into rauwolscinic acid, C2oH2403N2.H20, m.p. 262-4°C (dec.); [α]23D + l36.So (H20) which yields a crystalline hydrochloride, m.p. 255.5-257.5°C (dec.) and on esterification with MeOH reverts to the original alkaloid. On distillation with Zn dust, rauwolscine yields harman, 2-methylindole (skatole) and isoquinoline.
Chakravarti has shown that the alkaloid is a cardiovascular depressant, shows hypotensive activity and is relatively highly toxic.

Biological Activity

Standard α 2 -adrenergic antagonist (K i values are 3.5, 4.6 , and 0.6 nM at cloned human α 2A , α 2B , and α 2C -adrenoceptors respectively). Partial agonist at 5-HT 1A receptors. Also available as part of the α 2 -Adrenoceptor Tocriset™ .

References

Mukherjee., J. Ind. Chern. Soc., 18, 33, 485 (1941)
Mukherjee., ibid, 20, 11 (1943)
Mukherjee., ibid, 23, 6 (1946)
Pharmacology:
Chakravarti., Sci. Cult., (Calcutta), 7, 45S (1942)

RAUWOLSCINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


RAUWOLSCINE HYDROCHLORIDE Suppliers

Global( 73)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Effepharm (Shanghai) Co., Ltd
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HENAN BON INDUSTRIAL CO.,LTD
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CONIER CHEM AND PHARMA LIMITED
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Wuhan Nutra Biotechnology Co.,Ltd
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Baoji Guokang Healthchem co.,ltd
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View Lastest Price from RAUWOLSCINE HYDROCHLORIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 RAUWOLSCINE HYDROCHLORIDE
6211-32-1
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-02 Rauwolscine hydrochloride
6211-32-1
US $0.00 / Kg/Bag 100g/Bag 99% 1-10 tons Henan Weian Pharmaceutical Co. LTD
2021-11-02 Rauwolscine Hydrochloride,Rauwolscine
6211-32-1
US $0.00 / Kg/Bag 100g/Bag 99% 1-10 tons Henan Weian Pharmaceutical Co. LTD

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