Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Synephrine hydrochloride

Synephrine hydrochloride

Synephrine hydrochloride Structure
Synephrine hydrochloride structure
CAS No.
5985-28-4
Chemical Name:
Synephrine hydrochloride
Synonyms
SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
CBNumber:
CB1690109
Molecular Formula:
C9H14ClNO2
Molecular Weight:
203.67
MDL Number:
MFCD00050566
MOL File:
5985-28-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
(±)-Synephrine (hydrochloride) 28398 10g $95
(±)-Synephrine (hydrochloride) 28398 50g $220
(±)-Synephrine (hydrochloride) 28398 5g $57
(±)-Synephrine (hydrochloride) 28398 25g $152
rac-SynephrineHydrochloride S920001 100g $410
More product size
Request For Quotation

Synephrine hydrochloride Properties

Melting point 147-150°C
storage temp. Refrigerator
solubility Methanol (Slightly), Water (Slightly)
form Solid
color Off-White to Pale Beige
Cosmetics Ingredients Functions ANTIOXIDANT
SKIN CONDITIONING
HAIR CONDITIONING
InChI InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP -0.030 (est)
CAS DataBase Reference 5985-28-4(CAS DataBase Reference)
FDA UNII EN5D1IH09S

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2922498590
NFPA 704
0
2 0

Synephrine hydrochloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28398 (±)-Synephrine (hydrochloride) 5985-28-4 10g $95 2024-03-01 Buy
Cayman Chemical 28398 (±)-Synephrine (hydrochloride) 5985-28-4 50g $220 2024-03-01 Buy
Cayman Chemical 28398 (±)-Synephrine (hydrochloride) 5985-28-4 5g $57 2024-03-01 Buy
Cayman Chemical 28398 (±)-Synephrine (hydrochloride) 5985-28-4 25g $152 2024-03-01 Buy
TRC S920001 rac-SynephrineHydrochloride 5985-28-4 100g $410 2021-12-16 Buy
Product number Packaging Price Buy
28398 10g $95 Buy
28398 50g $220 Buy
28398 5g $57 Buy
28398 25g $152 Buy
S920001 100g $410 Buy

Synephrine hydrochloride Chemical Properties,Uses,Production

Description

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Chemical Properties

Pale Beige Solid

Uses

A α-adrenergic receptor agonist, vasoconstrictor.

References

[1] YI-TSAU HUANG . Fructus aurantii reduced portal pressure in portal hypertensive rats[J]. Life sciences, 1995, 57 22: Pages 2011-2020. DOI: 10.1016/0024-3205(95)02195-o
[2] JOSEP MERCADER. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium.[J]. Journal of physiology and biochemistry, 2011, 67 3: 443-452. DOI: 10.1007/s13105-011-0078-2
[3] NA-YOUNG HONG. p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells[J]. Biochemical and biophysical research communications, 2012, 418 4: Pages 720-724. DOI: 10.1016/j.bbrc.2012.01.085
[4] GUOYI MA. Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes.[J]. Planta medica, 2010, 76 10: 981-986. DOI: 10.1055/s-0029-1240884
[5] J A BEVAN  J V O. Relative sensitivity of some large blood vessels of the rabbit to sympathomimetic amines.[J]. Journal of Pharmacology and Experimental Therapeutics, 1965, 150 3: 370-374.

Synephrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Synephrine hydrochloride Suppliers

Global( 383)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu ChenLv Herb Co.,Ltd
+86-13608205856; +undefined13608205856 maryextract@126.com China 127 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 283 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 477 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Shenzhen Aoxi Technology Co., Ltd. 		+852-46424790 frank88rawpowder@outlook.com China 162 58
Lianyungang Kaiyu Environmental Tech Co., Ltd. 		+86-0086-19851820538 +8619851820538 carlos@khonorchem.com China 314 58
Supplier Advantage
Chengdu ChenLv Herb Co.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
BINBO BIOLOGICAL CO.,LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shenzhen Aoxi Technology Co., Ltd. 		58
Lianyungang Kaiyu Environmental Tech Co., Ltd. 		58

Related articles

View Lastest Price from Synephrine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Synephrine hydrochloride pictures 2026-04-26 Synephrine hydrochloride
5985-28-4
 US $0.00 / KG 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Synephrine hydrochloride pictures 2026-04-24 Synephrine hydrochloride
5985-28-4
 US $0.00-0.00 / kg 1kg 98 888kgs Xi an Biohorlden Industry Trade Co Ltd
Synephrine hydrochloride pictures 2026-04-24 Synephrine hydrochloride
5985-28-4
 US $0.00-0.00 / kg 1kg 99% 20t Jinan Jianfeng Chemical Co., Ltd

Synephrine hydrochloride Spectrum

Synephrine hydrochloride(5985-28-4)1HNMR

5985-28-4(Synephrine hydrochloride)Related Search:

Methoxyammonium chloride D-Glucosamine hydrochloride DIETHANOLAMINE HYDROCHLORIDE 4-Hydroxyaniline hydrochloride L-Lysine hydrochloride
ETHANOLAMINE HYDROCHLORIDE Ethyl acetate Topotecan hydrochloride Aminoacetonitrile hydrochloride Pyridine hydrochloride
Synephrine Triethylamine hydrochloride Monoethanolamine Sylvestroside I Syringaresinol-di-O-glucoside
Aminoguanidine hydrochloride 2-Methylaminoethanol 2-Dimethylaminoethanol

1of4

1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride 4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride l-1-p-hydroxyphenyl-2-methylamino-1-ethanolhydrochloride p-hydroxy-alpha-((methylamino)methyl)-benzylalcohohydrochloride p-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride p-methylaminoaethanolphenolhydrochlorid SYNEPHRINE HYDROCHLORIDE N-METHYL OCTOPAMINE HCL p-methylaminoethanolphenolhydrochloride 4-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol hydrochloride SYNEPHRINE HYDROCHLORIDE 98.0%MIN (±)-Oxedrine hydrochloride (±)-p-Hydroxynorephedrine hydrochloride dl-p-Hydroxynorephedrine hydrochloride Sympathol hydrochloride Benzenemethanol, 4-Hydroxy-α-((methylamino)methyl)-,hydrochloride p-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride UNII-EN5D1IH09S 4-Hydroxy-α-[(MethylaMino)Methyl]benzeneMethanol Hydrochloride rac-Synephrine Hydrochloride SYNEPHRINE HYDROCHLORIDE; OXEDRINE HYDROCHLORIDE (+)p-synephrine hydrochloride 4-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol hyd p-Methylaminoaethanolphenol hydrochlorid [German] [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylammonium chloride [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methyl-ammonium chloride [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylazanium chloride [2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methyl-azanium chloride 4-[1-hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxysuccinate (salt) 4-[1-hydroxy-2-(MethylaMino)ethyl]phenol hydrochloride Supply High Quality Synephrine hydrochloride powder CAS NO.:5985-28-4 CAS NO.5985-28-4 Synephrine/Synephrine Hcl JACS-5985-28-4 Synephrine hydrochloride, 98%, an α-adrenergic and -adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids Benzenemethanol, 4-hydroxy-a-[(methylamino)methyl]-, hydrochloride top quality Synephrine hydrochloride Synephrine hydrochloride USP/EP/BP Synephrine hydrochlorid Pharmaceutical Intermediate CAS?5985-28-4?Synephrine Hydrochloride Synephrine HCl Synephrine HCl 98%min Synephrine hydrochloride, 10 mM in DMSO (±)-Synephrine (hydrochloride) SYNEPHRINE HCL 5985-28-4 227-804-6 8985-28-4 5983-28-4 85-28-4 5984-28-4 59485-28-4 C9H14NO2Cl Amines Inhibitors Intermediates & Fine Chemicals Pharmaceuticals 5985-28-4