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NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE structure

CAS No.: 220805-22-1

Chemical Name:: NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Synonyms: ADMA;ADMA 2HCL;ADMA DIHYDROCHLORIDE;asym-Dimethylarginine;asym-Dimethylarginine, ADMA;Arginine Impurity 12 Dihydrochloride;NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE;NG,NG-dimethyl-L-Arginine (hydrochloride);NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE;NG,NG-Dimethylarginine Dihydrochloride，ADMA

CBNumber:: CB1706734

Molecular Formula:: C8H20Cl2N4O2

Molecular Weight:: 275.18

MDL Number:: MFCD00270857

MOL File:: 220805-22-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Properties

Melting point	202-204OC
storage temp.	room temp
solubility	DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
form	White to off-white crystalline solid.
color	White to Off-White
Water Solubility	Soluble in water (100 mM)
Stability	Store at 0-5°C; Moisture Sensitive; Hygroscopic
CAS DataBase Reference	220805-22-1

SAFETY

Risk and Safety Statements

WGK Germany	3

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D4268	NG,NG-Dimethylarginine dihydrochloride	220805-22-1	10mg	$80.7	2024-03-01	Buy
Sigma-Aldrich	D4268	NG,NG-Dimethylarginine dihydrochloride	220805-22-1	50mg	$281	2024-03-01	Buy
Sigma-Aldrich	311203	NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC?? = 2-3 μM) and in vivo.	220805-22-1	25MG	$187	2024-03-01	Buy
Cayman Chemical	80230	NG,NG-dimethyl-L-Arginine (hydrochloride) ≥98%	220805-22-1	5mg	$25	2024-03-01	Buy
Cayman Chemical	80230	NG,NG-dimethyl-L-Arginine (hydrochloride) ≥98%	220805-22-1	10mg	$45	2024-03-01	Buy

Product number	Packaging	Price	Buy
D4268	10mg	$80.7	Buy
D4268	50mg	$281	Buy
311203	25MG	$187	Buy
80230	5mg	$25	Buy
80230	10mg	$45	Buy

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

Uses

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

General Description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Biological Activity

ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

in vitro

ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].

in vivo

animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

storage

Room temperature (desiccate)

References

[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Suppliers

Global( 73)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Standardpharm Co. Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
China National Standard Pharmaceutical Corporation Limited	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50

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NG,NG-Dimethylarginine Dihydrochloride Solution, 100ppm asym-Dimethylarginine, ADMA NG,NG-dimethyl-L-Arginine (hydrochloride) (S)-2-aMino-5-(3,3-diMethylguanidino)pentanoic acid dihydrochloride NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE N5-[(DIMETHYLAMINO)IMINOMETHYL]-L-ORNITHINE, DIHYDROCHLORIDE ADMA ADMA 2HCL ADMA DIHYDROCHLORIDE asym-Dimethylarginine Arginine Impurity 12 Dihydrochloride NG,NG-Dimethylarginine Dihydrochloride，ADMA (Z)-N~5~-[amino(dimethylamino)methylidene]-L-ornithine dihydrochloride NG，NG-dimethyl-L-Arginine hydrochloride (ADMA) NG,NG dimethyl L Arginine dihydrochloride,NG,NGdimethylLArginine dihydrochloride Asymmetric dimethylarginine (dihydrochloride) 220805-22-1 Biochemicals and Reagents BioChemical Enzyme Inhibitors Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Enzyme L to O Nitric Oxide Synthase Amino Acids 13C, 2H, 15N Amino Acids & Derivatives Intermediates & Fine Chemicals Pharmaceuticals