HYPOPHYLLANTHIN
- CAS No.
- 33676-00-5
- Chemical Name:
- HYPOPHYLLANTHIN
- Synonyms
- NSC 619044;HYPOPHYLLANTIN;HYPOPHYLLANTHIN;(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole;(7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole;Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-;Inhibitor,CD243,Pgp,inhibit,Hypophyllanthin,ABCB1,P-glycoprotein,P-gp,Cluster of differentiation 243,Multidrug resistance protein 1,MDR1
- CBNumber:
- CB1716924
- Molecular Formula:
- C24H30O7
- Molecular Weight:
- 430.49
- MDL Number:
- MFCD03424459
- MOL File:
- 33676-00-5.mol
| Melting point | 129-130℃ |
|---|---|
| Boiling point | 511.1±50.0 °C(Predicted) |
| Density | 1.158 |
| storage temp. | 4°C, protect from light |
| solubility | ≤0.2mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide |
| form | crystalline solid |
| LogP | 3.770 (est) |
| FDA UNII | 22ZZ21E33P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| NFPA 704 |
|
HYPOPHYLLANTHIN price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89713 | Hypophyllanthin phyproof? Reference Substance | 33676-00-5 | 10mg | $873 | 2024-03-01 | Buy |
| Cayman Chemical | 11715 | Hypophyllanthin ≥98% | 33676-00-5 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 11715 | Hypophyllanthin ≥98% | 33676-00-5 | 5mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 11715 | Hypophyllanthin ≥98% | 33676-00-5 | 10mg | $448 | 2024-03-01 | Buy |
| Cayman Chemical | 11715 | Hypophyllanthin ≥98% | 33676-00-5 | 25mg | $965 | 2024-03-01 | Buy |
HYPOPHYLLANTHIN Chemical Properties,Uses,Production
Description
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 μM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.
Uses
Hypophyllanthin can be used to study the modulation of NSAID-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants.
in vitro
previous study found that hypophyllanthin could inhibit p-gp function with comparable potencies, but could not affect mrp2 activity. when hypophyllanthin was washed out before addition of substrate, the inhibitory action against p-gp function was lost. these results indicated the reversibility of the inhibition. moreover, prolonged exposure of the caco-2 cells to hypophyllanthin up to 7 days had no effect on p-gp function [1].
in vivo
a previous study was conducted to evaluate the effect of carbofuran on estrous cycle and follicular growth in virgin wister rats as well as recovering from the damaged estrous cycle with treatment of hypophyllanthin. hypophyllanthin is non-steroidal plant molecule with estrogen-like activities, but with an estrogen-type activity. hypophyllanthin was capable of interacting with estrogen receptors, showing both agonist and antagonist methods of action. therefore, hypophyllanthin was found to be systemically transformed into enterolignan, which is known to be responsible for augmenting estrus cycle in rats [2].
References
[1] n. sukhaphirom, n. vardhanabhuti, h. chirdchupunseree, et al. phyllanthin and hypophyllanthin inhibit function of p-gp but not mrp2 in caco-2 cells. journal of pharmacy and pharmacology 65, 292-299 (2012).
[2] aminul islam et al. estrogenic properties of phyllanthin and hypophyllanthin from phyllanthus amarus against carbofuran induced toxicity in female rats. pharmacologyonline 3: 1006-1016 (2008).
HYPOPHYLLANTHIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
View Lastest Price from HYPOPHYLLANTHIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | HYPOPHYLLANTHIN
33676-00-5
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
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- HYPOPHYLLANTHIN
33676-00-5
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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