Escin | 6805-41-0

Escin Properties

Melting point	224.5°C
Boiling point	764.81°C (rough estimate)
Density	1.1200 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	4°C, protect from light
solubility	Soluble in methanol.
form	powder
color	white
Merck	13,3730
Stability	Hygroscopic
CAS DataBase Reference	6805-41-0
EWG's Food Scores	1
FDA UNII	RUU8G67GQM

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H332
Precautionary statements	P261-P264-P270-P271-P304+P340+P312-P501
Hazard Codes	Xn
Risk Statements	22-20/22
Safety Statements	22-24/25
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS	KF6296000

Escin price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E1378	Escin ≥95%, powder	6805-41-0	1g	$103	2024-03-01	Buy
Sigma-Aldrich	E1378	Escin ≥95%, powder	6805-41-0	5g	$393	2024-03-01	Buy
Alfa Aesar	J66968	Aescin, 98%	6805-41-0	1g	$66.5	2024-03-01	Buy
Alfa Aesar	J66968	Aescin, 98%	6805-41-0	5g	$211.65	2024-03-01	Buy
Sigma-Aldrich	E1378	Escin ≥95%, powder	6805-41-0	10g	$626	2024-03-01	Buy

Product number	Packaging	Price	Buy
E1378	1g	$103	Buy
E1378	5g	$393	Buy
J66968	1g	$66.5	Buy
J66968	5g	$211.65	Buy
E1378	10g	$626	Buy

Escin Chemical Properties,Uses,Production

Chemical Properties

saponin mixture

Originator

Aescin,Sinochem

Uses

membrane permeabilizer

Uses

escin is a saponin occurring in the seed of the horse chestnut tree.

Uses

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.

Manufacturing Process

The 1st method of preparation of escin (US Patent No. 3,238,190):
500 g of pulverized horse chestnut seeds were extracted two times for 1 hour with 2.5 L each of aqueous 50% methanol with stirring. The solution was filtered, additional methanol was added thereto to increase the methanol concentration to 65%, and then it was filtered again. The obtained solution containing the extracted saponin had a pH of 5 and was passed through a column of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 of Farben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1% sulfuric acid and then had been washed neutral with 65% methanol. The solution leaving the resin had a pH in the range of about 3 to 4 and was concentrated by distillation to about 4/5 of its original volume. On cooling, crystallization of the escin started and the solution was allowed to stand until the crystallization had been completed. Escin having a melting point of 224- 226°C was obtained in a yield of 2%, calculated on the starting material.
The 2st method of preparations of escin (US Patent No. 3,163,636):
An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10% aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for 1 hour, while the ether is distilled off. The water insoluble saponin-cholesterol precipitate is centrifuged and washed with cold water until the wash water is colorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. The residue is treated with 20 kg of methanol and the undissolved material is filtered off. The yellowish methanol solution is treated with activated charcoal until it is colorless. The methanol is distilled off in a vacuum, and the residue is dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. The yield of pure sodium escinate obtained thereby is about 0.8 kg (8%).

Therapeutic Function

Antiedemic, Capillary protective

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Flammability and Explosibility

Non flammable

Escin Preparation Products And Raw materials

Raw materials

Methanol Cholesterol

Preparation Products

Escin Suppliers

Global( 262)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Greenpure Biopharma CO.,Ltd	18283602253	jancyzheng@gcgreenpure.com	China	952	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58

Supplier	Advantage
Chengdu Greenpure Biopharma CO.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58
TopScience Biochemical	58

View Lastest Price from Escin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Escin; Horse chestnut extract 6805-41-0	US $0.00 / KG	1KG	20%; 40%; 98% UV	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2023-11-27	Escin 6805-41-0	US $17.00 / kg	1kg	99%	100kg	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-11-13	BETA-AESCIN 6805-41-0	US $16.00 / kg	1kg	99%	100kg	Wuhan Han Sheng New Material Technology Co.，Ltd

Escin; Horse chestnut extract
6805-41-0
US $0.00 / KG
20%; 40%; 98% UV
Changsha Staherb Natural Ingredients Co., Ltd.

Escin
6805-41-0
US $17.00 / kg
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

BETA-AESCIN
6805-41-0
US $16.00 / kg
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

Escin Spectrum

Escin(6805-41-0)MS Escin(6805-41-0)IR1 Escin(6805-41-0)IR2

6805-41-0(Escin)Related Search:

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Escin, monosodium salt Escin IA (Aescin IA) Escin IB(Aescin IB)

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ESCIN Chestnuts extract (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid a-4700 aescusan amorphousaescin reparilu Escin(aescin) Chestnuts ESCIN, MIXTURE OF SAPONINS SodiumAescinate97-103% Aescine/Escin20%,95-103% Escigenin, 3-(4-O-β-D-glucopyranosyl-2-O-β-D- hydroxy-2-methylbutyrate,acetate xylopyranosyl-β-D-glucopyranuronoside), 3- 3β-[(4-O-β-D-Galactopyranosyl-2-O-β-D-xylo-hexopyranosyl-β-D-glucopyranuronosyl)oxy]-28-[2-methyl-1-oxo-3-(acetyloxy)butoxy]oleana-12-ene-16α,21α,22β,24-tetraol Sodium Aescinate P.E. Escin,Aescin Escin Synonyms Aescin Horse Chestnut seed extract Aescin,Horse Chestnuts extract 6-[[(4S,6aR,6bS,8aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(2-methyl-1-oxobut-2-enoxy)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4- Horse Chestnut Extract (Standard) Escin (mixture of natural saponins, Technical Grade) Aescin (Horse Chestnut extract) (2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14aR,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2E)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid 044 044-04 [as hydrobromide] UK-116 BETA-AESCIN AESCIN escina Escine Escin USP/EP/BP Aescin or escin Aescine,mixture 6805-41-0 Polysaccharide Monosaccharides Specialty Synthesis BioChemical Biochemicals and Reagents Carbohydrates Carbohydrate Synthesis Inhibitors Herb extract