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2,4,5-Trifluorobenzoic acid

2,4,5-Trifluorobenzoic acid structure

CAS No.: 446-17-3

Chemical Name:: 2,4,5-Trifluorobenzoic acid

Synonyms: 2,4,5-Trilfuorobenzoic acid;2,4,5-TrifL;RARECHEM AL BO 0258;2,4,5-Trifluorobenzo;5-Trifluorobenzoic acid;2,4,5-tifluorobenzoicacid;2,4,5-TRIFLUOROBENZOIC ACID;Benzoic acid, 2,4,5-trifluoro-;2,4,5-Trifluorobenzoic acid 99%;2,4,5-Trifluorobenzoic acid ,99%

CBNumber:: CB1742985

Molecular Formula:: C7H3F3O2

Molecular Weight:: 176.09

MDL Number:: MFCD00013306

MOL File:: 446-17-3.mol

MSDS File:: SDS

Last updated:2024-04-19 20:05:26

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2,4,5-Trifluorobenzoic acid Properties

Melting point	94-96 °C (lit.)
Boiling point	241.9±35.0 °C(Predicted)
Density	1.4362 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
pka	2.87±0.10(Predicted)
color	Off-White
BRN	3257609
InChIKey	AKAMNXFLKYKFOJ-UHFFFAOYSA-N
CAS DataBase Reference	446-17-3(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2,4,5-trifluoro- (446-17-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29163990

NFPA 704

	0
2		0

2,4,5-Trifluorobenzoic acid price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	328154	2,4,5-Trifluorobenzoic acid 99%	446-17-3	5g	$25.62	2024-03-01	Buy
TCI Chemical	T1586	2,4,5-Trifluorobenzoic Acid >97.0%(GC)(T)	446-17-3	5g	$54	2024-03-01	Buy
TCI Chemical	T1586	2,4,5-Trifluorobenzoic Acid >97.0%(GC)(T)	446-17-3	25g	$216	2024-03-01	Buy
Alfa Aesar	A14193	2,4,5-Trifluorobenzoic acid, 98%	446-17-3	5g	$94.65	2024-03-01	Buy
Alfa Aesar	A14193	2,4,5-Trifluorobenzoic acid, 98%	446-17-3	1g	$30.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
328154	5g	$25.62	Buy
T1586	5g	$54	Buy
T1586	25g	$216	Buy
A14193	5g	$94.65	Buy
A14193	1g	$30.5	Buy

2,4,5-Trifluorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.

Preparation

Synthesis of 2,4,5-trifluorobenzoic acid: Tetrachloroisophthalonitrile was used as the starting material, which was fluoridated, selectively reduced, and partially defluoridated to obtain 2,4,5-trifluoroisophthalonitrile. This compound was hydrolyzed to form 2,4,5-trifluoroisophthalic acid. Then, selective decarboxylation of 2,4,5-trifluorobenzoic acid was carried out to prepare 2,4,5-trifluorobenzoic acid.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 168, 1991 DOI: 10.1021/jm00105a025

General Description

2,4,5-Trifluorobenzoic acid is an important quinolone antibacterial intermediate. It is used in the synthesis of Temafloxacin and liquid crystals, among others.

2,4,5-Trifluorobenzoic acid synthesis

Synthesis of 2,4,5-Trifluorobenzoic acid from HEXAMIDINE

2,4,5-Trifluorobenzoic acid Preparation Products And Raw materials

Raw materials

1,2,4-Trifluorobenzene Isophthalic acid Chlorothalonil 2,4-Difluoroaniline

Preparation Products

2,5-Difluorophenol ABT-492 Propanedioic acid, 2-(2,4,5-trifluorobenzoyl)-, 1,3-diethyl ester

2,4,5-Trifluorobenzoic acid Suppliers

Global( 470)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1290	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2,4,5-Trifluorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	2,4,5-trifluorobenzoic acid 446-17-3	US $20.00 / KG	1KG	98%	446-17-3	Speranza Chemical Co., Ltd.
2024-04-20	2,4,5-Trifluorobenzoic acid 446-17-3	US $35.00-1.10 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-06	2,4,5-Trifluorobenzoic acid 446-17-3	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

2,4,5-trifluorobenzoic acid
446-17-3
US $20.00 / KG
98%
Speranza Chemical Co., Ltd.

2,4,5-Trifluorobenzoic acid
446-17-3
US $35.00-1.10 / kg
99%
Henan Fengda Chemical Co., Ltd

2,4,5-Trifluorobenzoic acid
446-17-3
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2,4,5-Trifluorobenzoic acid Spectrum

2,4,5-Trifluorobenzoic acid(446-17-3)MS 2,4,5-Trifluorobenzoic acid(446-17-3)¹HNMR 2,4,5-Trifluorobenzoic acid(446-17-3)¹³CNMR 2,4,5-Trifluorobenzoic acid(446-17-3)IR1 2,4,5-Trifluorobenzoic acid(446-17-3)IR2 2,4,5-Trifluorobenzoic acid(446-17-3)Raman

446-17-3(2,4,5-Trifluorobenzoic acid)Related Search:

ALUMINUM FORMATE 3-(Trifluoromethyl)benzoic acid Triethyl orthoformate Florfenicol Trimethoxymethane

Pentafluorobenzoic acid Trimesic acid 4-Fluorobenzoic acid 1,3,5-Trifluorobenzene 2,4,5-Trifluorobenzyl alcohol

2,3,4-Trifluorobenzoic acid Tetrafluorophthalic anhydride 3-HYDROXY-2,4,5-TRIFLUOROBENZOIC ACID METHYL PENTAFLUOROBENZOATE Tetrafluorophthalic acid

ETHYL PENTAFLUOROBENZOATE 2,3,4,5-Tetrafluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZOIC ACID,3-Methoxy-2,4,5-Trifluorobenzoic Acid 2,4,5-Trifluoro-3-Methoxybenzoic Acid

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2,4-trifluorobenzoic acid and derivatives 2,4,5-TRIFLUOROBENZOIC ACID AND THE DERIVATIVES 2,4,5-TrifluoroBenzoicacidsolution 2,4,5-Trifluorobenzoic acid, 99.5+% 2,4,5-Trifluorobenzoic acid 20% solution 2,4,5-Trifluorobenzoic acid 99% RARECHEM AL BO 0258 2,4,5-Trifluorobenzoic acid ,99% 2,4,5-Trifluorobenzo 2,4,5-Trifluorobenzoic acid, 99.5+%, 99.5+% 5-Trifluorobenzoic acid 2,4,5-tifluorobenzoicacid 2,4,5-TRIFLUOROBENZOIC ACID 2,4,5-TrifL Benzoic acid, 2,4,5-trifluoro- 2,4,5-Trilfuorobenzoic acid 446-17-3 Carbonyl Compounds Carboxylic Acids ARYL ACID Organic Building Blocks C7 Building Blocks Pyridines ,Halogenated Heterocycles C7 Carbonyl Compounds Carboxylic Acids Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Miscellaneous blocks Carboxes FluoroCompounds bc0001