ChemicalBook >> CAS DataBase List >>1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

CAS No.
79183-19-0
Chemical Name:
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Synonyms
CS-572;MDK83190;APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;Apoptosis Activator 2, >=98%;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP;1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
CBNumber:
CB1755989
Molecular Formula:
C15H9Cl2NO2
Molecular Weight:
306.14
MDL Number:
MFCD00141556
MOL File:
79183-19-0.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Properties

Boiling point 470.6±55.0 °C(Predicted)
Density 1.494
Flash point 238.4℃
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Soluble in DMSO
form Orange to red solid.
pka -2.69±0.20(Predicted)
Sensitive Light Sensitive
FDA UNII RSY8DE8DGH

SAFETY

Risk and Safety Statements

Safety Statements  24/25
RIDADR  3077
HS Code  29145090

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J65320 Apoptosis Activator 2 79183-19-0 5mg $92.1 2023-06-20 Buy
Alfa Aesar J65320 Apoptosis Activator 2 79183-19-0 25mg $272 2021-12-16 Buy
Cayman Chemical 10004176 Apoptosis Activator 2 79183-19-0 5mg $36 2024-03-01 Buy
Cayman Chemical 10004176 Apoptosis Activator 2 79183-19-0 10mg $66 2024-03-01 Buy
Cayman Chemical 10004176 Apoptosis Activator 2 79183-19-0 25mg $155 2024-03-01 Buy
Product number Packaging Price Buy
J65320 5mg $92.1 Buy
J65320 25mg $272 Buy
10004176 5mg $36 Buy
10004176 10mg $66 Buy
10004176 25mg $155 Buy

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties,Uses,Production

Uses

Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines

Uses

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

Definition

ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).

storage

Room temperature

References

[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 125)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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View Lastest Price from 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE pictures 2019-09-04 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
79183-19-0
US $5.00 / KG 1KG 99% 1ton Career Henan Chemical Co

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Spectrum

APOPTOSIS ACTIVATOR 2 APOPTOSIS ACTIVATOR II 1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]- Apoptosis Activator 2, >=98% Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer CS-572 1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione MDK83190 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP 79183-19-0 Inhibitors Caspases/Apoptosis