1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- CAS No.
- 79183-19-0
- Chemical Name:
- 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- Synonyms
- CS-572;MDK83190;APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;Apoptosis Activator 2, >=98%;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP;1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
- CBNumber:
- CB1755989
- Molecular Formula:
- C15H9Cl2NO2
- Molecular Weight:
- 306.14
- MDL Number:
- MFCD00141556
- MOL File:
- 79183-19-0.mol
- MSDS File:
- SDS
Boiling point | 470.6±55.0 °C(Predicted) |
---|---|
Density | 1.494 |
Flash point | 238.4℃ |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Soluble in DMSO |
form | Orange to red solid. |
pka | -2.69±0.20(Predicted) |
Sensitive | Light Sensitive |
FDA UNII | RSY8DE8DGH |
SAFETY
Risk and Safety Statements
Safety Statements | 24/25 |
---|---|
RIDADR | 3077 |
HS Code | 29145090 |
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J65320 | Apoptosis Activator 2 | 79183-19-0 | 5mg | $92.1 | 2023-06-20 | Buy |
Alfa Aesar | J65320 | Apoptosis Activator 2 | 79183-19-0 | 25mg | $272 | 2021-12-16 | Buy |
Cayman Chemical | 10004176 | Apoptosis Activator 2 | 79183-19-0 | 5mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 10004176 | Apoptosis Activator 2 | 79183-19-0 | 10mg | $66 | 2024-03-01 | Buy |
Cayman Chemical | 10004176 | Apoptosis Activator 2 | 79183-19-0 | 25mg | $155 | 2024-03-01 | Buy |
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties,Uses,Production
Uses
Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines
Uses
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
Definition
ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
storage
Room temperature
References
[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-04 | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
79183-19-0
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
- 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
79183-19-0
- US $5.00 / KG
- 99%
- Career Henan Chemical Co
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