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p-Toluenesulfonic acid

Overview Refer to quality standards Chemical properties Uses Production method Hazards & Safety Information
p-Toluenesulfonic acid
p-Toluenesulfonic acid structure
CAS No.
104-15-4
Chemical Name:
p-Toluenesulfonic acid
Synonyms
TsOH;TL65;PTSA;TSA-95;TL65LS;Tsa-hp;Tsa-mh;TSA-65W;TSA-65M;Eltesol
CBNumber:
CB1771154
Molecular Formula:
C7H8O3S
Formula Weight:
172.2
MOL File:
104-15-4.mol

p-Toluenesulfonic acid Properties

Melting point:
106~107℃
Boiling point:
116 °C
Density 
1.07
refractive index 
1.3825-1.3845
Flash point:
41 °C
storage temp. 
Flammables area
pka
-0.43±0.50(Predicted)
form 
Solution
color 
Clear colorless to light yellow
Water Solubility 
soluble
Indirect Additives used in Food Contact Substances
4-METHYLBENZENESULFONIC ACID
FDA 21 CFR
175.105
CAS DataBase Reference
104-15-4(CAS DataBase Reference)
FDA UNII
QGV5ZG5741
NIST Chemistry Reference
P-toluene sulfonic acid(104-15-4)
EPA Substance Registry System
4-Methylbenzenesulfonic acid (104-15-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  C
Risk Statements  34-10
Safety Statements  45-26-23
RIDADR  2585
HazardClass  8
PackingGroup  III
HS Code  29163990
NFPA 704
1
3 2
W

p-Toluenesulfonic acid Chemical Properties,Uses,Production

Overview

p-toluene sulfonic acid (Its molecular structural formula is p-CH3C6H4SO3H, also known as TsOH, English name is p-toluene sulfonic acid) referred to as PTS, is a non-oxidizing organic acid, white needle or powder crystals, soluble in water, alcohols, ethers and other polar solvents. Easy deliquescence, easy to make wood, cotton fabric dehydration and carbonization, insoluble in benzene and toluene. generating p-cresol when alkali fusion. Commonly, p-toluenesulfonic acid-monohydrate (TsOHH2O) or tetrahydrate (TsOH4H2O) is preferred.
Preparation of methyl p-cresol acid in industry is by using concentrated sulfuric acid on the toluene sulfonation of p-toluenesulfonic acid. The preparated p-toluenesulfonic acid often contains benzene sulfonic acid and sulfuric acid impurities, can be purified in recrystallization of concentrated hydrochloric acid, azeotropic drying.
p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis. It is neutralized with sodium hydroxide and then obtains sodium p-toluene sulfonate, and react with phosphorus pentachloride, can obtains p-toluenesulfonyl chloride. The latter used in the nucleophilic substitution reaction, also used as alcohol hydroxyl protective group. p-CH3C6H4SO3Na + PCl5 →p-CH3C6H4SO2Cl.
The use of p-toluenesulfonic acid also catalyzes the protection of dihydrofuran on the alcohol, carboxylic acid esterification, transesterification reaction, making the aldehyde generate acetal.

Refer to quality standards

Item/Index Industrial Grade Pharmaceutical Grade Refined Grade Reagent Grade (Chemically Pure)
Content (as C7H8O3S • H2O)% ≥ 90-93.0 96.0 97.0 98.0
Free acid (H2SO4) ≤% 3.0 0.7 0.5 0.1
Moisture (excluding crystal water) ≤% 4.0 3.5 2.5 1.5
Iron (in Fe ++) ≤ ppm 50 30 30 10
Ignition residue ≤%/0.2 0.2 0.02
Melting point (°C)// 102-105
Ethanol dissolved test/qualified qualified qualified
Water dissolution test/qualified qualified qualified

Chemical properties

Colorless monoclinic sheet or columnar crystals. Soluble in ethanol and ether, slightly soluble in water and hot benzene.

Uses

(1) For chemical reagents, but also for dyes, organic synthesis.
(2) Used as the intermediates of medicine (such as doxycycline), pesticides (such as dicofol), dyes. Also used in detergents, plastics, coatings and so on.
(3) For medicine, pesticides, dyes and detergents, but also for plastics and printing coatings.
(4) Widely used in the catalyst synthetic medicine, pesticides, polymerization of the stabilizer and organic synthesis (esters, etc.). Also used as medicine, paint intermediates and resin curing agent.

Production method

By p-toluenesulfonyl chloride hydrolysis derived. Toluene can also be used as raw materials, sulfonated by sulfuric acid derived.

Hazards & Safety Information

Category:Corrosive articles
Toxicity classification:Low toxicity
Acute toxicity
Oral-rat LD50: 2480 mg/kg
Flammability hazard characteristics
Combustible; fire in the release of toxic sulfur dioxide gas
Storage and transportation characteristics
Storehouse is ventilates, low temperature and dry; Store with base separately
Extinguishing agent
Mist water, carbon dioxide, foam

Description

p-Toluene sulfonic acid (PTSA) or tosylic acid (TsOH) is an organic compound with the formula CH3C6H4SO3H. It is a white solid that is soluble in water, alcohols, and other polar organic solvents. The 4-CH3C6H4SO2- group is known as tosyl group and is often abbreviated as Ts or Tos. Most often, TsOH refers to the monohydrate, TsOH.H2O.
TsOH is a strong organic acid, about a million times stronger than benzoic acid. It is one of the few strong acids that is solid and, hence, conveniently weighed. Also, unlike some strong mineral acids (especially nitric acid, sulfuric acid, and per chloric acid), TsOH is non - oxidizing.

Chemical Properties

Clear colorless to light yellow solution

Definition

ChEBI: An arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group.

Reactions

p-Toluene sulfonic acid may be converted to p-toluene sulfonic anhydride by heating with phosphorus pentoxide.
When TsOH is heated with acid and water, a hydrolysis reaction takes place and toluene is formed:
CH3C6H4SO3H + H2O → C6H5CH3 + H2SO4
This reaction is general for aryl sulfonic acids, but the rate at which it occurs depends upon the structure of the acid, the temperature and the nature of the catalyzing acid. For example p- TsOH is unaffected by cold concentrated hydrochloric acid, but hydrolyzes when heated to 186°C in concentrated phosphoric acid.

Preparation and handling

TsOH is prepared on an industrial scale by the sulfonation of toluene. It hydrates readily. Common impurities include benzene sulfonic acid and sulfuric acid. Impurities can be removed by recrystallization from its concentrated aqueous solution followed by azeotropic drying with toluene.
Toluene sulfonic acid finds use in organic synthesis as an "organic - soluble" acid catalyst. Examples of uses :
Acetalization of an aldehyde.
Esterification of carboxylic acids.
Trans esterification of an ester.

Tosylate esters

Tosylate esters are used as alkylating agents because the tosyl group is electron-with drawing, which makes the tosylate anion a good leaving group. The tosyl group is also a protecting group for alcohols and amines, prepared by combining the alcohol with 4- toluenesulfonyl chloride, usually in an aprotic solvent, often pyridine, the basicity of which activates the reaction. Toluenesulfonate esters undergo nucleophilic attack or elimination. Reduction of tosylate esters gives the hydrocarbon. Thus, tosylation followed by reduction allows for the deoxygenation of alcohols.

p-Toluenesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products


p-Toluenesulfonic acid Suppliers

Global( 407)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
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+86-371-55531817
info@dakenchem.com CHINA 21837 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2655 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hebei Ruishun Trade Co.,LTD
17052563120
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Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58

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View Lastest Price from p-Toluenesulfonic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-10 p-Toluenesulfonic acid
104-15-4
1KG 99% + 500 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.
2019-04-02 4-Toluenesulfonic acid Manufacturer; In stock GMP Factory
104-15-4
US $1.00-1.00 / KG 1 KG/CTN High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2018-09-04 p-Toluenesulfonic acid
104-15-4
US $1.00 / G 100G 99.9% 50000tons Hebei Ruishun Trade Co.,Ltd

p-Toluenesulfonic acid Spectrum


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