DWP14012 hydrochloride
- CAS No.
- 1902954-87-3
- Chemical Name:
- DWP14012 hydrochloride
- Synonyms
- DWP14012 HCl;DWP-14012 HCl;DWP 14012 HCl;DWP14012 hydrochloride;Abeprazan hydrochloride
- CBNumber:
- CB18054297
- Molecular Formula:
- C19H18ClF3N2O3S
- Molecular Weight:
- 446.87
- MDL Number:
- MFCD34469942
- MOL File:
- 1902954-87-3.mol
DWP14012 hydrochloride Chemical Properties,Uses,Production
Biological Activity
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1]. Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].
References
[1]. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.
DWP14012 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
DWP14012 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd. | 0531-58897130 15508676053 | drug_impurity@sdcclh.com | China | 1743 | 58 |
| Chengdu anman biomedical technology co., LTD | 028-86617873 18113025300 | yukijiangli@amanbio.com | China | 105 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10529 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509 | 643638326@qq.com | China | 5347 | 58 |
| RD International Technology Co., Limited | 18988968278 | sales@ubiochem.com | China | 9146 | 58 |