c-Met-IN-2
- CAS No.
- 1635406-73-3
- Chemical Name:
- c-Met-IN-2
- Synonyms
- c-Met-IN-2;c Met IN 2,cMetIN2;1H-Pyrazole-1-ethanol, 4-[1-[1-[7-fluoro-3-(1-methyl-1H-pyrazol-4-yl)-6-quinolinyl]ethyl]-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-
- CBNumber:
- CB18054343
- Molecular Formula:
- C24H21FN10O
- Molecular Weight:
- 484.49
- MDL Number:
- MFCD31692326
- MOL File:
- 1635406-73-3.mol
c-Met-IN-2 Chemical Properties,Uses,Production
Description
c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity.
c-Met-IN-2 (Compound 14) is a potent and selective c-Met inhibitor, with an IC50 of 0.6 nM. c-Met-IN-2 also shows weak activity on other kinases, with IC50s of 1075 nM (AxI), 731 nM (RON), 18364 nM (VEGFR2), 5396 nM (c-Kit), 2357 nM (PDGFRa), 17056 nM (c-Src).
c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumor in mice bearing H1993 tumors, and has similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg[1].
References
[1]. Zhao F, et al. Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization. Eur J Med Chem. 2017 Jul 7;134:147-158.
c-Met-IN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
c-Met-IN-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 56 |
| TargetMol Chemicals Inc. | 58 |