ChemicalBook >> CAS DataBase List >>9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- CAS No.
- 2342583-66-6
- Chemical Name:
- 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- Synonyms
- inhibit,NCC-007,Inhibitor,NCC007,NCC 007,Casein Kinase;9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine;9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- CBNumber:
- CB18245224
- Molecular Formula:
- C22H28F3N7
- Molecular Weight:
- 447.5
- MDL Number:
- MFCD32067989
- MOL File:
- 2342583-66-6.mol
Last updated:2023-03-13 11:54:02
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P305+P351+P338 |
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0097017 | NCC007 99.58% | 2342583-66-6 | 5mg | $100 | 2021-12-16 | Buy |
ChemScene | CS-0097017 | NCC007 99.58% | 2342583-66-6 | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0097017 | NCC007 99.58% | 2342583-66-6 | 25mg | $250 | 2021-12-16 | Buy |
ChemScene | CS-0097017 | NCC007 99.58% | 2342583-66-6 | 50mg | $450 | 2021-12-16 | Buy |
ChemScene | CS-0097017 | NCC007 99.58% | 2342583-66-6 | 100mg | $750 | 2021-12-16 | Buy |
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Chemical Properties,Uses,Production
Biological Activity
NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms.
in vivo
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.
Animal Model: | Adult C57BL/6J background male mice (8 weeks old) |
Dosage: | 5 , 15 mM |
Administration: | Infused into the lateral ventricle, constant dark condition |
Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. | < /tr>
target
CKIα 1.8 μM (IC 50 ) | CKIδ 3.6 μM (IC 50 ) |
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Suppliers
Global( 20)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2995 | 58 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9242 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine
inhibit,NCC-007,Inhibitor,NCC007,NCC 007,Casein Kinase
2342583-66-6
C22H28F3N7