(S,R,S)-AHPC-PEG6-Azide
- CAS No.
- 2086298-71-5
- Chemical Name:
- (S,R,S)-AHPC-PEG6-Azide
- Synonyms
- (S,R,S)-AHPC-PEG6-Azide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-23-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber:
- CB18362273
- Molecular Formula:
- C36H55N7O10S
- Molecular Weight:
- 777.94
- MDL Number:
- MFCD32669901
- MOL File:
- 2086298-71-5.mol
(S,R,S)-AHPC-PEG6-Azide Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG6-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
(S,R,S)-AHPC-PEG6-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
(S,R,S)-AHPC-PEG6-Azide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9779 | 58 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1350 | 58 |
Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 8780 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
View Lastest Price from (S,R,S)-AHPC-PEG6-Azide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | (S,R,S)-AHPC-PEG6-Azide
2086298-71-5
|
US $0.00 / mg | 100mg | >98.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
- (S,R,S)-AHPC-PEG6-Azide
2086298-71-5
- US $0.00 / mg
- >98.00%
- Xian confluore Biological Technology Co., Ltd.