ChemicalBook >> CAS DataBase List >>GW441756
GW441756
- CAS No.
- 504433-23-2
- Chemical Name:
- GW441756
- Synonyms
- Gw;CS-1085;W 441756;GW441758;GW 441756;GW441756, >98%;GW441756 USP/EP/BP;GW 441756; GW-441756;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
- CBNumber:
- CB1839809
- Molecular Formula:
- C17H13N3O
- Molecular Weight:
- 275.3
- MDL Number:
- MFCD08703104
- MOL File:
- 504433-23-2.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Boiling point | 568.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| pka | 11.04±0.20(Predicted) |
| form | solid |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GW441756 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 16915 | GW 441756 ≥95% | 504433-23-2 | 10mg | $113 | 2024-03-01 | Buy |
| Tocris | 2238 | GW441756 ≥99%(HPLC) | 504433-23-2 | 50 | $927 | 2021-12-16 | Buy |
| Tocris | 2238 | GW441756 ≥99%(HPLC) | 504433-23-2 | 10 | $221 | 2021-12-16 | Buy |
GW441756 Chemical Properties,Uses,Production
Description
GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).
Uses
GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.
Definition
ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.
Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
storage
Store at RT
References
1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]
GW441756 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 122)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE
GW 441756
Gw
2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-
(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
GW 441756; GW-441756
CS-1085
GW441756, >98%
W 441756
GW441756 USP/EP/BP
3-((1-methyl-1H-indol-3-yl)methylene)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one
GW441758
504433-23-2
504433-23-3
Angiogenesis and Metastasis
Inhibitors