ChemicalBook >> CAS DataBase List >>N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE structure

CAS No.: 127243-85-0

Chemical Name:: N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

Synonyms: H-89;CS-2385;H-89 hcl;H89 DIHCL;H-89 free base;H-89 ＆ H-89 2HCl;H-89 HYDROCHLORIDE;H-89 DIHYDROCHLORIDE;H-89 dihydrochloride,98%;Protein kinase inhibitor H-89

CBNumber:: CB1853005

Molecular Formula:: C20H20BrN3O2S

Molecular Weight:: 446.36

MDL Number:: MFCD00214119

MOL File:: 127243-85-0.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:20

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N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Properties

Melting point	195-200°C
Boiling point	639.7±65.0 °C(Predicted)
Density	1.436
storage temp.	2-8°C
solubility	H₂O: ≥10 mg/mL
form	powder
pka	10.43±0.50(Predicted)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference	127243-85-0(CAS DataBase Reference)
FDA UNII	M876330O56

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H302-H312-H319-H332
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362
Safety Statements	22-24/25
WGK Germany	3
HS Code	29350090

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	2910	H89dihydrochloride ≥98%(HPLC)	127243-85-0	50	$878	2021-12-16	Buy
Tocris	2910	H89dihydrochloride ≥98%(HPLC)	127243-85-0	1	$93	2021-12-16	Buy
Tocris	2910	H89dihydrochloride ≥98%(HPLC)	127243-85-0	10	$203	2021-12-16	Buy
TRC	B682440	N-[2-(p-Bromocinnamylamino)ethyl]-5-IsoquinolineSulfonamide	127243-85-0	5mg	$50	2021-12-16	Buy
Usbiological	P9104-35	Protein Kinase Inhibitor H-89	127243-85-0	10mg	$375	2021-12-16	Buy

Product number	Packaging	Price	Buy
2910	50	$878	Buy
2910	1	$93	Buy
2910	10	$203	Buy
B682440	5mg	$50	Buy
P9104-35	10mg	$375	Buy

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA? IC50?= 140 nM).? Inhibits a variety of other kinases including S6K1 (IC50?= 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 μM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 μM).1,2

Chemical Properties

White Solid

Uses

Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM

Uses

Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.

Definition

ChEBI: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]et ane-1,2-diamine.

General Description

A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (K_i = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (K_i = 28.3 μM), Ca²⁺/calmodulin-dependent protein kinase II (K_i = 29.7 μM), protein kinase C (K_i = 31.7 μM), casein kinase I (K_i = 38.3 μM), and Rho Kinase II (IC₅₀ = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 mM) by blocking the action of Rho kinase II.

Biological Activity

Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b).

Biochem/physiol Actions

Target Ki: 48 nM for protein kinase A

References

1) Lochner and Moolman (2006),?The many faces of H89: a review; Cardiovasc. Drugs,?24?261 2) Bain?et al. (2007),?The selectivity of protein kinase inhibitors: a further update; Biochem.J.?408(Pt3)?297

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58

Supplier	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58

View Lastest Price from N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	H-89 dihydrochloride 127243-85-0	US $1.00 / KG	1KG	97%-99.9%	100kg	Career Henan Chemical Co

H-89 dihydrochloride
127243-85-0
US $1.00 / KG
97%-99.9%
Career Henan Chemical Co

127243-85-0(N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE)Related Search:

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Propylamine H-89 DIHYDROCHLORIDE HYDRATE N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

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H-89 H-89 DIHYDROCHLORIDE H-89 HYDROCHLORIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE H-89 dihydrochloride,98% H89 DIHCL N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride H-89, Dihydrochloride Salt >99% N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide N-(2-((3-(4-BroMophenyl)allyl)aMino)ethyl)isoquinoline-5-sulfonaMide dihydrochloride 5-IsoquinolinesulfonaMide,N-[2-[[3-(4-broMophenyl)-2-propen-1-yl]aMino]ethyl]- Protein kinase inhibitor H-89 H-89 hcl H-89 ＆ H-89 2HCl N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide H-89 dihydrochloride, 98%, a potent and selective inhibitor of PKA H 89 2HCl,H 89 dihydrochloride H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem CS-2385 H 89 (Protein kinase inhibitor H-89 N-[2-[3-(4-bromophenyl)prop-2-enylamino]ethyl]-5-isoquinolinesulfonamide dihydrochloride N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLI H-89 free base 127243-85-0 C20H22BrN3O2SCl2 C20H22BrCl2N3O2S C20H20BrN3O2S2HCl C20H20BrN3O2S C20H20BrN3O2S2ClH Kinase/Phosphatase Biology Protein Kinase A (PKA) Serine/Threonine Kinase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience Inhibitor Protein Kinase Inhibitors and Activators