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Hydralazine structure
Chemical Name:
c5968;ba5968;c-5068;apressin;ciba5968;apresolin;aprezolin;NSC 126699;apresoline;hidralazin
Molecular Formula:
Formula Weight:
MOL File:

Hydralazine Properties

Melting point:
Boiling point:
276.07°C (rough estimate)
1.2583 (rough estimate)
refractive index 
1.5872 (estimate)
pKa 6.820± 0.005(H2O,t = 25.0,Iundefined) (Uncertain)
Water Solubility 
4.8mg/L(22.5 ºC)
CAS DataBase Reference
3 (Vol. 24, Sup 7) 1987
NIST Chemistry Reference
1(2H)-phthalazinone, hydrazone(86-54-4)
EPA Substance Registry System
Hydralazine (86-54-4)
  • Risk and Safety Statements
Toxicity LD50 in mice, rats (mg/kg): 122, 90 orally; 101, 40 i.p. (Dorigotti)

Hydralazine Chemical Properties,Uses,Production


Cross-reactions between hydrazine derivatives occur. Hydralazine may sometimes cause flushing and reversible Lupus erythematosis

Chemical Properties

Yiellow Solid


Apresoline HCl,Ciba,US,1952


Hydralazine is widely used cardiovascular drug dilating arterioies by relaxation of artetiolar smooth muscles.


Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; semicarbazide-sensitive amine oxidase inhibitor. Antihypertensive


Hydralazine is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. Non-selective MAO-A/B inhibitor; semicarbazide-sensitive amine oxidase inhibitor. Antihypertensive.


ChEBI: The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Manufacturing Process

30 parts by weight of phthalazone are converted to 1-chlorophthalazine by the method described in Ber. d. deutsch. chem. Ges., vol 26, page 521 (1893). The freshly obtained yet moist chloro compound is heated on the water bath for two hours in a mixture of 100 parts by volume of ethyl alcohol and 90 parts by volume of hydrazine hydrate. Preferably after filtering, 1-hydrazinephthalazine crystallizes out in yellow needles on cooling.
It is filtered with suction and washed with cold ethyl alcohol. The compound is crystallized from methyl alcohol, and melts, when rapidly heated, at 172° to 173°C. On warming in alcoholic or aqueous hydrochloric acid, the hydrochloride of MP 273°C (with decomposition) is obtained.

brand name

Apresoline (Novartis); Dralzine (Teva).

Therapeutic Function


Biological Functions

The vasodilation produced by hydralazine (Apresoline) depends in part on the presence of an intact blood vessel endothelium. This implies that hydralazine causes the release of nitric oxide, which acts on the vascular smooth muscle to cause relaxation. In addition, hydralazine may produce vasodilation by activating K+ channels.

Contact allergens

Hydralazine is a hydrazine derivative used as a antihypertensive drug. Skin rashes have been described during treatment. Exposure occurs mainly in the pharmaceutical industry. Cross-sensitivity is frequent with hydrazine, which is considered to be a potent sensitizer.

Mechanism of action

Hydralazine exhibits an antihypertensive effect by directly relaxing smooth muscles of the vessels. It has an effect on arterial vessels while having a minimal effect on venous vessels. As a result, resistance of peripheral vessels decreases, and blood pressure is reduced (diastolic more than systolic).
It does not have a substantial effect on nonvascular smooth musculature or cardiac tissues. Homeostatic circulatory reflexes remain natural, and the resulting hypotension activates cardiovascular reflexes, which are expressed as an increase of heart work, power, and volume of cardiac output. Therefore, it is most effectively used in combination with β-blockers.


Hydralazine produces widespread but apparently not uniform vasodilation; that is, vascular resistance is decreased more in cerebral, coronary, renal, and splanchnic beds than in skeletal muscle and skin. Renal blood flow and ultimately glomerular filtration rate may be slightly increased after acute treatment with hydralazine. However, after several days of therapy, the renal blood flow is usually no different from that before drug use.
In therapeutic doses, hydralazine produces little effect on nonvascular smooth muscle or on the heart. Its pharmacological actions are largely confined to vascular smooth muscle and occur predominantly on the arterial side of the circulation; venous capacitance is much less affected. Because cardiovascular reflexes and venous capacitance are not affected by hydralazine, postural hypotension is not a clinical concern. Hydralazine treatment does, however, result in an increase in cardiac output.This action is brought about by the combined effects of a reflex increase in sympathetic stimulation of the heart, an increase in plasma renin, and salt and water retention. These effects limit the hypotensive usefulness of hydralazine to such an extent that it is rarely used alone.

Clinical Use

Hydralazine is generally reserved for moderately hypertensive ambulatory patients whose blood pressure is not well controlled either by diuretics or by drugs that interfere with the sympathetic nervous system. It is almost always administered in combination with a diuretic (to prevent Na+ retention) and a β-blocker, such as propranolol (to attenuate the effects of reflex cardiac stimulation and hyperreninemia). The triple combination of a diuretic, β-blocker, and hydralazine constitutes a unique hemodynamic approach to the treatment of hypertension, since three of the chief determinants of blood pressure are affected: cardiac output (β-blocker),plasma volume (diuretic), and peripheral vascular resistance (hydralazine).
Although hydralazine is available for intravenous administration and has been used in the past for hypertensive emergencies, it is not generally employed for this purpose. The onset of action after intravenous injection is relatively slow, and its actions are somewhat unpredictable in comparison with those of several other vasodilators.

Side effects

Most side effects associated with hydralazine administration are due to vasodilation and the reflex hemodynamic changes that occur in response to vasodilation. These side effects include headache, flushing, nasal congestion, tachycardia, and palpitations. More serious manifestations include myocardial ischemia and heart failure. These untoward effects of hydralazine are greatly attenuated when the drug is administered in conjunction with a β-blocker.
When administered chronically in high doses, hydralazine may produce a rheumatoidlike state that when fully developed, resembles disseminated lupus erythematosus.

Chemical Synthesis

Hydralazine, 1-hydrazinonaphthalazine (22.6.4), is synthesized by the oxidative chlorination of phthalide with simultaneous hydrolysis of product, which results in hydroxyphthalide (22.6.1), which upon reaction with hydrazine changes to phthalazone (22.6.2). This undergoes a reaction with phosphorous oxychloride, forming 1-chlorophthalazine (22.6.3), in which substitution of the chlorine atom with hydrazine gives the desired hydralazine (22.6.4).


Hydralazine is well absorbed (65–90%) after oral administration. Its peak antihypertensive effect occurs in about 1 hour, and its duration of action is about 6 hours.
The major pathways for its metabolism include ring hydroxylation, with subsequent glucuronide conjugation and N-acetylation. Hydralazine exhibits a first-pass effect in that a large part of an orally administered dose is metabolized before the drug reaches the systemic circulation. The first-pass metabolism occurs in the intestinal mucosa (mostly N-acetylation) and the liver. The primary excretory route is through renal elimination, and about 80% of an oral dose appears in the urine within 48 hours. About 10% is excreted unchanged in the feces.
Approximately 85% of the hydralazine in plasma is bound to plasma proteins. Although this does not appear to be a major therapeutic concern, the potential for interactions with other drugs that also bind to plasma proteins does exist. The plasma half-life of hydralazine in patients with normal renal function is 1.5 to 3 hours.
Interestingly, the half-life of the antihypertensive effect is somewhat longer than the plasma half-life. This may occur because hydralazine is specifically accumulated in artery walls, where it may continue to exert a vasodilator action even though plasma concentrations are low.
The plasma half-life of hydralazine may be increased fourfold or fivefold in patients with renal failure. If renal failure is present, therefore, both the antihypertensive and toxic effects of hydralazine may be enhanced. Since N-acetylation of hydralazine is an important metabolic pathway and depends on the activity of the enzyme N-acetyltransferase, genetically determined differences in the activity of this enzyme in certain individuals (known as slow acetylators) will result in higher plasma levels of hydralazine; therefore, the drug’s therapeutic or toxic effects may be increased.

Purification Methods

It crystallises from MeOH. UV: max 656nm at pH ~11. It complexes with Bi3+ , Zn2+ , Fe2+ and Co2+ .

Hydralazine Preparation Products And Raw materials

Raw materials

Preparation Products

Hydralazine Suppliers

Global( 54)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Standardpharm Co. Ltd.
86-714-3992388 United States 14344 58
Shaanxi Dideu Medichem Co. Ltd
029-88380327 CHINA 4149 58
Antai Fine Chemical Technology Co.,Limited
18503026267 CHINA 9664 58
Career Henan Chemica Co
13203830695 0371-86658258
0371-86658258 CHINA 30281 58
Xi'an MC Biotech, Co., Ltd.
18991951683 02989275612
8618991951683 CHINA 2309 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 CHINA 9937 58
Dideu Industries Group Limited
029-88380327 CHINA 29986 58
008657185134895 CHINA 15559 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 CHINA 52932 58

View Lastest Price from Hydralazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-11 Hydralazine USP/EP/BP
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
2020-05-10 Hydralazine
US $0.00-0.00 / Kg 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd

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