Ipronidazole
- CAS No.
- 14885-29-1
- Chemical Name:
- Ipronidazole
- Synonyms
- Ipropan;Ipropran;Ro7-1554;Ro 07-1554;NSC-109212;Ipronidazole Solution, 100ppm;1-Methyl-2-(1-Methylethyl)-5-nitro-;2-Isopropyl-1-methyl-5-nitroimidazol;2-Isopropyl-1-methyl-5-nitroimidazole;1-methyl-5-nitro-2-propan-2-ylimidazole
- CBNumber:
- CB1875030
- Molecular Formula:
- C7H11N3O2
- Molecular Weight:
- 169.18
- MDL Number:
- MFCD00866597
- MOL File:
- 14885-29-1.mol
- MSDS File:
- SDS
| Melting point | 60° |
|---|---|
| Boiling point | 298.47°C (rough estimate) |
| Density | 1.2509 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| solubility | DMF: 14 mg/mL; DMSO: 11 mg/mL; Ethanol: 12 mg/mL; PBS (pH 7.2): 0.16 mg/mL |
| pka | 2.55±0.25(Predicted) |
| Water Solubility | 9.4g/L(20 ºC) |
| BRN | 744577 |
| FDA UNII | 045BU63E23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Toxicity | LD50 orally in poults: 640 ± 25 mg/kg (Marusich, p 92) | |||||||||
| NFPA 704 |
|
Ipronidazole price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 32173 | Ipronidazole VETRANAL , analytical standard | 14885-29-1 | 10mg | $676 | 2024-03-01 | Buy |
| TRC | I747000 | Ipronidazole | 14885-29-1 | 100mg | $840 | 2021-12-16 | Buy |
| TRC | I747000 | Ipronidazole | 14885-29-1 | 50mg | $435 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008016 | IPRONIDAZOLE 95.00% | 14885-29-1 | 1G | $1871.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008016 | IPRONIDAZOLE 95.00% | 14885-29-1 | 100MG | $739.2 | 2021-12-16 | Buy |
Ipronidazole Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Ipropran,Roche,W. Germany,1981
Uses
Ipronidazole may be used as a reference standard in the determination of ipronidazole in tissue samples using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC) and thermospray tandem mass spectrometry (HPLC-MS/MS).
Uses
An antihistomonal agent. Antiprotozoal (Histomonas).
Definition
ChEBI: Ipronidazole is a C-nitro compound and a member of imidazoles.
Manufacturing Process
2-Isopropyl-4 (or 5-nitroimidazole) (31 g = 0.2 mol), dioxane (70 g) and
dimethylsulfate (28 g = 0.22 mol) were heated on a steam bath under reflux
for 45 minutes. The solvent was removed in vacuo on a steam bath, the
residue dissolved in 20 ml of water and the product precipitated by the
gradual addition of 80 g of 25% sodium hydroxide solution at 0°C. A small
additional amount was obtained by extraction of the mother liquor with
methylene chloride. The product melted at 60°C.
The product was purified as follows. 60 g of product was dissolved in 3N
aqueous hydrochloric acid, the solution was treated with charcoal and filtered.
The filtrate was neutralized by the gradual addition of aqueous concentrated
ammonia at 0°C to 5°C under stirring whereupon the product precipitated in
white plates as the neutralization proceeded. The precipitate was filtered by
suction, washed on the filter with 50 ml of ice cold water and dried at room
temperature, MP 60°C.
The hydrochloride salt was formed by reacting the product, dissolved in
isopropanol, with 25% ethanolic hydrochloric acid, whereupon the salt
precipitated and was isolated. It has a melting point of 177°C to 182°C (dec).
Similarly, the bisulfate salt was formed using 96% sulfuric acid. It has a MP of
151.5°C to 152.5°C.
brand name
Ipropran [Veterinary] (Hoffmann-LaRoche).
Therapeutic Function
Antiprotozoal
General Description
Ipronidazole is a veterinary drug, which is widely used in controlling histomoniasis in turkeys.
Ipronidazole Preparation Products And Raw materials
Ipronidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9664 | 58 |
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