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Glibornuride

Glibornuride structure

CAS No.: 26944-48-9

Chemical Name:: Glibornuride

Synonyms: N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide;Glitrim;Ro-6-4563;Glibornurid;Glibornuride;Glibornuride USP/EP/BP;Glibornuride (Mixture of Diastereomers);Glibornuride Solution in Acetonitrile/Water, 1000μg/mL;1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea;1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea

CBNumber:: CB1875191

Molecular Formula:: C18H26N2O4S

Molecular Weight:: 366.47504

MDL Number:: MFCD00869202

MOL File:: 26944-48-9.mol

Last updated:2023-09-04 15:51:00

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Glibornuride Properties

Melting point	192-195° (ethanol-water); also reported as 195-198°
alpha	D +63.8° (ethanol)
Density	1.1793 (rough estimate)
refractive index	1.6930 (estimate)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)
pka	5.20±0.10(Predicted)
FDA UNII	VP83E7434R
ATC code	A10BB04

Glibornuride price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	G409700	Glibornuride	26944-48-9	10mg	$240	2021-12-16	Buy
Usbiological	164299	Glibornuride	26944-48-9	2.5mg	$355	2021-12-16	Buy
American Custom Chemicals Corporation	API0010408	GLIBORNURIDE 95.00%	26944-48-9	1MG	$750.75	2021-12-16	Buy
American Custom Chemicals Corporation	API0010408	GLIBORNURIDE 95.00%	26944-48-9	5MG	$1963.5	2021-12-16	Buy
AvaChem	3155	Glibornuride	26944-48-9	25mg	$390	2021-12-16	Buy

Product number	Packaging	Price	Buy
G409700	10mg	$240	Buy
164299	2.5mg	$355	Buy
API0010408	1MG	$750.75	Buy
API0010408	5MG	$1963.5	Buy
3155	25mg	$390	Buy

Glibornuride Chemical Properties,Uses,Production

Originator

Glutril,Roche,W. Germany,1972

Uses

Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.

Definition

ChEBI: Glibornuride is a monoterpenoid.

Manufacturing Process

2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a few drops of dilute hydrochloric acid. The precipitate is removed by filtration, washed with water and suspended in 100 ml of water. The suspension is dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is extracted with ether, acidified with dilute hydrochloric acid and filtered. The precipitate is washed with water and recrystallized from alcohol/water to yield 1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a melting point of 193° to 195°C.

brand name

Glutril (Hoffmann-LaRoche).

Therapeutic Function

Oral hypoglycemic

Glibornuride Preparation Products And Raw materials

Raw materials

Preparation Products

Glibornuride Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from Glibornuride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-06-09	Glibornuride USP/EP/BP 26944-48-9	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Glibornuride USP/EP/BP
26944-48-9
US $1.10 / g
99.9%
Dideu Industries Group Limited

Glibornuride Spectrum

Glibornuride(26944-48-9)¹HNMR

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1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea Glibornuride Glitrim N-[[[(1S,2S,3R,4R)-2-Hydroxyborn-3-yl]amino]carbonyl]-4-methylbenzenesulfonamide Ro-6-4563 1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea 1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea 1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonyl-urea Glibornuride (Mixture of Diastereomers) 1-(3-hydroxy-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea Glibornurid Benzenesulfonamide, N-[[[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]amino]carbonyl]-4-methyl- Glibornuride Solution in Acetonitrile/Water, 1000μg/mL Glibornuride USP/EP/BP N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide Inhibitor,K channel,KcsA,blocker ATP,sensitive,Glibornuride,inhibit,Parsley,Streptozotocin,Antidiabetic,Potassium Channel N-(((1S,2S,3R,4S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide 26944-48-9 C18H26N2O4S Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds