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oxeladin

oxeladin
oxeladin structure
CAS No.
468-61-1
Chemical Name:
oxeladin
Synonyms
oxeladin;oxeladin USP/EP/BP;IQADUMSPOQKAAO-UHFFFAOYSA-N;2-(β-1Diethylaminoethoxy)ethyl diethylphenyl acetate;2-(2-diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate;2-[2-(Diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate;α,α-Diethylbenzeneacetic acid 2-(2-diethylaminoethoxy)ethyl ester;2-Ethyl-2-phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester;Benzeneacetic acid, α,α-diethyl-, 2-[2-(diethylamino)ethoxy]ethyl ester
CBNumber:
CB1875328
Molecular Formula:
C20H33NO3
Formula Weight:
335.48
MOL File:
468-61-1.mol

oxeladin Properties

Melting point:
25°C
Boiling point:
bp0.5 150°; bp0.1 140°
Density 
1.0720 (rough estimate)
refractive index 
1.5614 (estimate)
FDA UNII
SNC1080T5Y
ATC code
R05DB09

oxeladin Chemical Properties,Uses,Production

Originator

Silopentol,Schulte,W. Germany ,1970

Manufacturing Process

Preparation of Diethylphenylacetonitrile: 25 grams of sodium was dissolved in 300 ml liquid ammonia containing 0.3 gram ferric chloride and 59 grams phenylacetonitrile was added slowly with stirring. After about 15 minutes a cooled solution of 80 grams of ethyl chloride in 200 ml dry ether was added and the mixture stirred for 1 hour. The ammonia was then allowed to evaporate, water added and the ether layer separated, dried, concentrated and the residual oil distilled in vacuo to yield diethylphenylacetonitrile as an oil, BP 85°C/1 mm.
Preparation of Diethylphenylacetic Acid: 46 grams of the foregoing nitrile was added to 140 ml ethylene glycol containing 36 grams potassium hydroxide and the mixture refluxed with stirring for about 20 hours. The mixture was diluted with water, extracted with light petroleum (BP 60° to 80°C) to remove traces of impurities and then acidified to yield diethylphenylacetic acid which was recrystallized from dilute ethanol (40% v/v ethanol in water).
Preparation of 2-(β-Chloroethoxy)Ethyl Diethylphenylacetate: 19.2 grams of the foregoing acid was added to a solution of 4 grams of sodium hydroxide in 40 ml ethylene glycol. 28.6 grams β,β'-dichlorodiethyl ether was added and the mixture refluxed for 1 hour. After removal of solvent under reduced pressure, 150 ml water was added to the residue and the product extracted with ether. The ethereal solution was dried, concentrated and the residue distilled in vacuo to yield the product as an oil, BP 140°C/0.7 mm.
Preparation of 2-(β-Diethylaminoethoxy)Ethyl Diethylphenylacetate: A mixture of 21 grams of 2-(β-chloroethoxy)ethyl diethylphenylacetate and 14 grams diethylamine was heated under pressure in a sealed tube at 140°C for 5 hours. After cooling, the mixture was dissolved in dilute hydrochloric acid and extracted with ether to remove traces of neutral impurities. The acid layer was then made alkaline with 10% w/v sodium hydroxide solution with cooling, and re-extracted with two portions of ether. The ether extract was dried, the ether distilled off and the residue distilled in vacuo to yield the product as an oil, BP 140°C/0.1 mm.

Therapeutic Function

Antitussive

oxeladin Preparation Products And Raw materials

Raw materials

Preparation Products


oxeladin Suppliers

Global( 9)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
BOC Sciences 16314854226
sales@bocsci.com United States 9932 65
Wuhan pengyin Pharmaceutical Co., Ltd 13163333255
1939328613@qq.com China 397 58

View Lastest Price from oxeladin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-01 oxeladin USP/EP/BP
468-61-1
US $1.10 / g 1g 99.9% 100Tons min Dideu Industries Group Limited
2020-04-25 Oxeladin
468-61-1
US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd

468-61-1(oxeladin)Related Search:


  • 2-(2-diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate
  • oxeladin
  • 2-(β-1Diethylaminoethoxy)ethyl diethylphenyl acetate
  • 2-Ethyl-2-phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester
  • α,α-Diethylbenzeneacetic acid 2-(2-diethylaminoethoxy)ethyl ester
  • IQADUMSPOQKAAO-UHFFFAOYSA-N
  • 2-[2-(Diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate
  • Benzeneacetic acid, α,α-diethyl-, 2-[2-(diethylamino)ethoxy]ethyl ester
  • oxeladin USP/EP/BP
  • 468-61-1
  • 468-68-1
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