cycrimine hydrochloride
- CAS No.
- 126-02-3
- Chemical Name:
- cycrimine hydrochloride
- Synonyms
- NSC 169452;CoMpound 8958;Pagitane hydrochloride;cycrimine hydrochloride;Benzhexol Impurity 14（Cycrimine Hydrochloride）;1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol hydrochloride;1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride;1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol hydrochloride;1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-, hydrochloride
- CBNumber:
- CB1904475
- Molecular Formula:
- C19H29NO.ClH
- Molecular Weight:
- 0
- MDL Number:
- MFCD01700234
- MOL File:
- 126-02-3.mol
| Melting point | 239 - 241°C |
|---|---|
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| FDA UNII | 9RB4L4K895 |
cycrimine hydrochloride price
cycrimine hydrochloride Chemical Properties,Uses,Production
Originator
Pagitane,Lilly,US,1953
Uses
Cycrimine Hydrochloride is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
Definition
ChEBI: The hydrochloride salt of cycrimine. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease.
Manufacturing Process
The manufacture of the cyclohexyl analog is as follows. Phenyl magnesium bromide was prepared from 48.5 g (0.308 mol) of bromobenzene, 7 g (0.29 mol) of magnesium, and 125 ml of dry ether. To it was added at 5°C over a period of ? hour 40 g (0.18 mol) of cyclohexyl β-(N-piperidyl)-ethyl ketone (BP 115° to 117°C/1 mm) in 125 ml of dry ether. The mixture was allowed slowly to come to room temperature, refluxed for one hour, and then poured into ice containing 80 ml of concentrated hydrochloric acid. Ammonium chloride (100 g) and 200 ml of concentrated ammonium hydroxide were added and the organic layer was separated. After drying and removing the solvent, the residue was distilled under reduced pressure. The base distilled at 158° to 170°C (1 mm) and solidified. Upon recrystallization from methanol it melted at 112° to 113°C.
brand name
Pagitane (Lilly).
Therapeutic Function
Muscle relaxant, Antiparkinsonian
cycrimine hydrochloride Preparation Products And Raw materials
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