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Bemotrizinol

Bemotrizinol Structure
Bemotrizinol structure
CAS No.
187393-00-6
Chemical Name:
Bemotrizinol
Synonyms
BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE;uv-627;Tinosorb S Aqua;BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL;LGB-TS;CGF 1607;FAT 70'884;Tianlaisi S;Bemotrizino;BEMOTRIZINOL
CBNumber:
CB1959495
Molecular Formula:
C38H49N3O5
Molecular Weight:
627.81
MDL Number:
MFCD08435974
MOL File:
187393-00-6.mol
Last updated:2025-09-05 20:24:49
Product description Number Pack Size Price
Bemotrizinol certified reference material, pharmaceutical secondary standard PHR2793 400MG $152
Bemotrizinol analytical standard 51825 25mg $238
Bemotrizinol United States Pharmacopeia (USP) Reference Standard 1048572 200mg $467
Bemotrizinol B6145 1G $53
Bemotrizinol B6145 5G $143
More product size
Request For Quotation

Bemotrizinol Properties

Melting point 83-85°; mp 80° (Mongiat)
Boiling point 782.0±70.0 °C(Predicted)
Density 1.109±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka 8.08±0.40(Predicted)
form Solid
color Light Yellow to Yellow
Odor Odorless
BRN 11322254
InChIKey SUKLKCPPDPQLNJ-UHFFFAOYSA-N
SMILES N1=C(C2=CC=C(OC)C=C2)N=C(C2=CC=C(OCC(CC)CCCC)C=C2O)N=C1C1=CC=C(OCC(CC)CCCC)C=C1O
LogP 7.647 (est)
FDA UNII PWZ1720CBH
UNSPSC Code 77101502
NACRES NA.24

SAFETY

Risk and Safety Statements

Hazard statements  H413
WGK Germany  3
HS Code  2933690000

Bemotrizinol price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2793 Bemotrizinol certified reference material, pharmaceutical secondary standard 187393-00-6 400MG $152 2025-07-31 Buy
Sigma-Aldrich 51825 Bemotrizinol analytical standard 187393-00-6 25mg $238 2025-07-31 Buy
Sigma-Aldrich 1048572 Bemotrizinol United States Pharmacopeia (USP) Reference Standard 187393-00-6 200mg $467 2025-07-31 Buy
TCI Chemical B6145 Bemotrizinol 187393-00-6 1G $53 2025-07-31 Buy
TCI Chemical B6145 Bemotrizinol 187393-00-6 5G $143 2025-07-31 Buy
Product number Packaging Price Buy
PHR2793 400MG $152 Buy
51825 25mg $238 Buy
1048572 200mg $467 Buy
B6145 1G $53 Buy
B6145 5G $143 Buy

Bemotrizinol Chemical Properties,Uses,Production

Description

Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays. Compared to older broad-spectrum chemical agents, bemotrizinol is more more fat soluble (oil soluble in cosmetic oils) to aid in efficacy and broad-spectrum activity. It is claimed to be photostable, which increases its onset of action and its efficiency in providing protection against UV-rays upon topical application. Bemotrizinol is commonly marketed as Tinosorb S and Escalol S.

Uses

Bemotrizinol is a broad-spectrum UV absorber, absorbing both UVA and UVB. Bemotrizinol is added to various sunscreens to absorb UV rays.

Definition

ChEBI: Bemotrizinol is a member of methoxybenzenes.
The INCI name of Bemotrizinol is bis-ethylhexyloxyphenol methoxyphenyl triazine

Application

Bemotrizinol is an active sunscreen agent used in Europe and Australia and will often be paired with less photostable UV blockers such as avobenzone, as the combination creates a much more stable sunscreen that will not degrade and lose its efficacy when exposed to sunlight. In Australia, we need to wear sunscreen every day due to our high rates of skin cancer, and the fact that bemotrizinol can absorb both UVA and UVB rays, providing protection from skin diseases while also not losing effectiveness is an important consideration to make when purchasing sunscreen. Software's Daily Sun Defence SPF50+ protects against both UVA and UVB rays, helping to prevent photoageing, sun spots, and some skin cancers. The lightweight formulation blends seamlessly into the skin, sitting nicely under makeup without leaving a white cast.

brand name

Tinosorb S (Ciba Specialty Chemicals).

Flammability and Explosibility

Non flammable

Safety

Because bemotrizinol is relatively new to the sunscreen market there are few reports or studies available documenting its adverse effects and long term use. Studies to date have shown it to have a good safety profile. It is not significantly absorbed into the skin and rarely causes skin irritation. Unlike some other organic sunscreen agents, in vitro studies show that bemotrizinol does not appear to have hormonal effects. Further long-term human safety studies are required.

Synthesis

In a three-necked flask equipped with a stirrer, a thermometer and a condenser, 40.30 g (0.1 mol) of 2,4-bis(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazine, 29.02 g (0.21 mol) of potassium carbonate and 105 mL of N, N-dimethylformamide were added in sequence, and the temperature was raised to 100°C. Reflux and stir for 30 minutes; add 46.35g (0.24mol) of DMF solution containing isooctane bromide at a uniform rate within 1 hour, continue to reflux and stir at 100°C after the addition is complete, and monitor the reaction progress with a thin layer chromatography; after the reaction of the raw materials is completed, stop stirring, cool to room temperature, filter, add ethyl acetate to the filtrate for extraction, wash with saturated brine, dry the organic phase with anhydrous sodium sulfate, filter, and spin-dry the filtrate to obtain a colourless transparent oil, i.e. 50.4g of a crude product of bis-ethylhexyloxyphenol methoxyphenyl triazine (Bemotrizinol), with a yield of 80.2% and a purity of 89.90% detected by HPLC.

Advantages

The bis-ethylhexyloxyphenol methoxyphenyl triazine (Bemotrizinol) is a triazine ultraviolet absorbent, has efficient absorption in ultraviolet bands of UVA (320-400 nm) and UVB (280-320), has high molecular weight, is not easy to be absorbed by skin, has strong stability, and is widely applied to personal care and cosmetic products.

Regulations

Bemotrizinol is approved for use in Europe and Australasia. It is marketed under the brand names Tinosorb S and Escalol S. It is currently awaiting FDA approval so is not available in the USA.

Bemotrizinol synthesis

100-66-3
187393-00-6
Synthesis of Bemotrizinol from Anisole

Bemotrizinol Preparation Products And Raw materials

Raw materials

Preparation Products

Bemotrizinol Suppliers

Global( 361)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9941 58
Qingdao Truelight functional Material Technology Co., Ltd.
+86-13573844393 songjames@truelightchem.com China 221 58
ZhenYiBio Technology Inc
+8615309206328 alexxue@zhenyibio.com China 293 58
Watson Biotechnology Co.,Ltd
+86-18186686046 +86-18186686046; sales01@watsonbiotech.cn China 5746 58
Hangzhou Lin'an tianhong biotechnology co.,ltd.
+86-057158605786 +86-13606615626 admin@tianhongsw.com China 52 58
Yantai Fenglu Fine Chemical Co. LTD
+86-+undefined-008618315825527 kevin.wang@xhtechgroup.com China 122 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2953 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8768 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403; info@fortunachem.com China 5987 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5249 58
Supplier Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		58
Qingdao Truelight functional Material Technology Co., Ltd.
58
ZhenYiBio Technology Inc
58
Watson Biotechnology Co.,Ltd
58
Hangzhou Lin'an tianhong biotechnology co.,ltd.
58
Yantai Fenglu Fine Chemical Co. LTD
58
Jinan Finer Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58

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View Lastest Price from Bemotrizinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE pictures 2025-12-08 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE
187393-00-6
 0.99 RongNa Biotechnology Co.,Ltd
UV-627 pictures 2025-12-08 UV-627
187393-00-6
 US $0.00-0.00 / kg 1kg 99.33% 5000KGS WUHAN FORTUNA CHEMICAL CO., LTD
Bemotrizinol pictures 2025-12-08 Bemotrizinol
187393-00-6
 US $0.00-0.00 / kg 1kg 99% 20tons Wuhan Fortuna Chemical Co.,Ltd
  • UV-627 pictures
  • UV-627
    187393-00-6
  • US $0.00-0.00 / kg
  • 99.33%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Bemotrizinol pictures
  • Bemotrizinol
    187393-00-6
  • US $0.00-0.00 / kg
  • 99%
  • Wuhan Fortuna Chemical Co.,Ltd

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2,2′-[6-(4-Methoxyphenyl)- 1,3,5-triazine-2,4-diyl] bis{5-[(2-ethylhexyl)oxy]phenol} CGF 1607 FAT 70'884 6,6'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-(2-ethylhexyloxy)phenol) 2,4-Bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (6Z)-3-(2-Ethylhexoxy)-6-[(4Z)-4-[4-(2-ethylhexoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-6-(4-methoxyphenyl)-1H-1,3,5-triazin-2-ylidene]cyclohexa-2,4-dien-1-one Phenol, 2,2-6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diylbis5-(2-ethylhexyl)oxy- BISETHYLHEXYLOXYPHENOLMETHOXYPHENOLTRIAZINE Bemotrizinol (200 mg) BEMOTRIZINOL LGB-TS Bemotrizinol/Bis Ethyl Hexyl Oxyphenolmethoxyphenyl Triazine 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydrody]-phenyl}-6-(4-methoxyphenyl)-(1,3,5)-triazine Tinosorb S Bemotrizinol uv absorber UV-S IS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE Diethyl hexoxyphenol methoxyphenyl triazine Bis-ethylhexyloxyphenol methoxyphenyl triazine Solution in Methanol/THF/Water, 1000μg/mL UV ABSORBER TRUELICHT UV S Bis-ethylhexyloxyphenol methoxyphenyl triazine（BEMT） JADEWIN UV-S JADEWIN UV 627 Tinosorb S Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine CAS 187393-00-6 Tinosorb S BEMT Bemotrizinol (1048572) Tinosorb S Aqua BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE uv-627 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL Bemotrizinol(Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine)/BEMT Bemotrizinol / UV S Bi-ethylhexoxyphenol methoxyphenyltriquine Bi-ethylhexoxyphenol methoxyphenyltriazine 2-HYDROXYETHYLUREA 2078-71-9 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (TINOSARB) Dsunpro Bemt Bemotrizinol(Tinosorb S) 6,6'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylhexyl)oxy)phenol) BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (TINOSORB) Bemotrizinol/Bis-Ethylhexyloxyphenol 6,6'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylheptyl)oxy)phenol) Piraxostat Impurity 15 6,6'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylheptyl)oxy)phenol) （TS） 2,2'-[6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-[(2-ethylhexyl)oxy]phenol] Phenol,2,2'-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-[(2-ethylhexyl)oxy]- 2,2-[6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-[(2-ethylhexyl)oxy]phenol in methanol Bemotrizinol (BEMT) Bis-ethylhexyloxy phenol methosxyphenyl triazine Bis-Ethylhexyl Oxyphenol Methoxyphenyl Triazone Tianlaisi S Bis-Ethylhexyl Phenol Methoxyphenyl Triazine Bemotrizinol【51825】 Bemotrizino Bis-Ethylhexyphenol Methoxyphenyl Triazine (BTZ) Tian Lai Shi S 187393-00-6 C38H49N3O5