FLAVOPIRIDOL HYDROCHLORIDE
- CAS No.
- 131740-09-5
- Chemical Name:
- FLAVOPIRIDOL HYDROCHLORIDE
- Synonyms
- HL 275;CS-976;L-86-8276;NSC 649890;MDL 107826A;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HC;Flavopiridol HCI;FLAVOPIRIDOL HCL
- CBNumber:
- CB1972179
- Molecular Formula:
- C21H21Cl2NO5
- Molecular Weight:
- 438.3
- MDL Number:
- MFCD26792554
- MOL File:
- 131740-09-5.mol
Melting point | 169.5-170°C |
---|---|
alpha | 24D -1.73 to -3.9° |
storage temp. | 2-8°C |
solubility | H2O: ~2mg/mL |
pka | 5.68 ± 0.06(at 25℃) |
form | powder |
color | white to light brown |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month |
CAS DataBase Reference | 131740-09-5 |
FDA UNII | D48MS3A6N9 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DJ2978830 | |||||||||
NFPA 704 |
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FLAVOPIRIDOL HYDROCHLORIDE price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F3055 | Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder | 131740-09-5 | 5mg | $156 | 2024-03-01 | Buy |
Sigma-Aldrich | F3055 | Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder | 131740-09-5 | 25mg | $586 | 2024-03-01 | Buy |
Cayman Chemical | 10009197 | Flavopiridol (hydrochloride) ≥95% | 131740-09-5 | 5mg | $49 | 2024-03-01 | Buy |
Cayman Chemical | 10009197 | Flavopiridol (hydrochloride) ≥95% | 131740-09-5 | 10mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 10009197 | Flavopiridol (hydrochloride) ≥95% | 131740-09-5 | 25mg | $143 | 2024-03-01 | Buy |
FLAVOPIRIDOL HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.
Chemical Properties
Yellow Powder
Uses
Flavopiridol hydrochloride hydrate has been used:
- as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
- as an RNA polymerase inhibitor to study its effects on hepatic cells
- as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo
Uses
An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.
Definition
ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.
Biochem/physiol Actions
Flavopiridol?is a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).
storage
Store at +4°C
References
1) Kaur?et al. (1992),?Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275;? J. Natl. Cancer Inst.,?84?1736 2) Cartee?et al. (2002),?Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways;? Mol. Pharmacol.,?61?1313 3) Ambrosini?et al. (2008),?The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner;? Cancer Res.?68?2312 4) Schang?et al. (2004),?Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication;? Biochim. Biophys. Acta,?1697?197
FLAVOPIRIDOL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from FLAVOPIRIDOL HYDROCHLORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | FLAVOPIRIDOL HYDROCHLORIDE
131740-09-5
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co | ||
2019-07-06 | FLAVOPIRIDOL HYDROCHLORIDE
131740-09-5
|
US $7.00 / KG | 1KG | 99% | 1000KG | Career Henan Chemical Co |
- FLAVOPIRIDOL HYDROCHLORIDE
131740-09-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
- FLAVOPIRIDOL HYDROCHLORIDE
131740-09-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co