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Nigericin sodium salt

Nigericin sodium salt Structure
Nigericin sodium salt structure
CAS No.
28643-80-3
Chemical Name:
Nigericin sodium salt
Synonyms
Nsc292567;Helexin C;Nigerian Sodium;Sodium Nigericin;Nigericin sodiuM sa;Nigericin sodium salt;Nigericin, monosodium salt;Nigericin, sodium salt(1:1);SODIUM NIGERICIN;NSC-292567;Nigericin sodium salt USP/EP/BP
CBNumber:
CB1972391
Molecular Formula:
C40H69NaO11
Molecular Weight:
748.97
MDL Number:
MFCD30377206
MOL File:
28643-80-3.mol
MSDS File:
SDS
Last updated:2023-08-31 17:33:57
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Nigericin sodium salt Properties

Melting point approximate 255℃
storage temp. 2-8°C
solubility Soluble in chloroform, methanol or ethanol
form solution
color White
Merck 13,6569
BRN 3892398
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey MOYOTUKECQMGHE-NTQCAYBPSA-M
LogP 4.817 (est)
EWG's Food Scores 1
FDA UNII DGN38HI976

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P264-P270-P280-P301+P310-P305+P351+P338-P337+P313
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  QT6840000
HazardClass  6.1
HS Code  29419090
NFPA 704
0
3 0

Nigericin sodium salt price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 481990 Nigericin sodium salt 28643-80-3 5mg $80.7 2023-01-07 Buy
Sigma-Aldrich 481990 Nigericin sodium salt 28643-80-3 10mg $129 2022-05-15 Buy
Alfa Aesar J61349 Nigericin sodium salt, 98+% 28643-80-3 10mg $202 2024-03-01 Buy
Cayman Chemical 11437 Nigericin (sodium salt) ≥98% 28643-80-3 5mg $57 2024-03-01 Buy
Cayman Chemical 11437 Nigericin (sodium salt) ≥98% 28643-80-3 10mg $81 2024-03-01 Buy
Product number Packaging Price Buy
481990 5mg $80.7 Buy
481990 10mg $129 Buy
J61349 10mg $202 Buy
11437 5mg $57 Buy
11437 10mg $81 Buy

Nigericin sodium salt Chemical Properties,Uses,Production

Description

Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin Na is K+> Rb+> Cs+>>Na+. Cell permeable.

Chemical Properties

NIGERICIN SODIUM SALT is white powder

Uses

Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium is the atypical salt of nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

General Description

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at -20°C

References

1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613 2) Gong et al. (2010), Chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289

Nigericin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Nigericin sodium salt Suppliers

Global( 154)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 +8613734021967 kaia@neputrading.com China 1011 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 7838 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8822 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-18789408387 1057@dideu.com China 3783 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanxi Naipu Import and Export Co.,Ltd 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58

View Lastest Price from Nigericin sodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nigericin sodium salt pictures 2024-04-19 Nigericin sodium salt
28643-80-3
 US $10.00 / kg 1kg 99 10000kg/month Hebei Yime New Material Technology Co., Ltd.
Nigericin sodium salt pictures 2023-08-31 Nigericin sodium salt
28643-80-3
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Nigericin sodium salt pictures 2022-10-19 Nigericin sodium salt
28643-80-3
 US $50.00 / kg 1kg 99% 1 Hebei Duling International Trade Co. LTD

Nigericin sodium salt Spectrum

Nigericin sodium salt(28643-80-3)MS

28643-80-3(Nigericin sodium salt)Related Search:

Sodium hydroxide Sodium formate Sodium carbonate Sodium benzoate Sodium bicarbonate
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8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Nigericin sodium salt sodium

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Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464 Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate Nigericin, monosodium salt Nsc292567 Nigericin sodium salt,Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A Nigericin sodiuM sa Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464, Pandavir Nigericin Nigericin sodium salt Helexin C Nigericin, sodium salt(1:1) Nigericin sodium salt Nigerian Sodium Nigericin sodium salt, 98%, from Streptomyces hygroscopicus (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem Sodium Nigericin SODIUM NIGERICIN;NSC-292567 Nigericin sodium salt USP/EP/BP 28643-80-3 C40H67O11Na Nigericin sodium salt Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate 28643-80-3 C40H67NaO11 C40H67O11Na API