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N-Boc-4-piperidinemethanol

CAS No.
123855-51-6
Chemical Name:
N-Boc-4-piperidinemethanol
Synonyms
TERT-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;N-BOC-piperidine-4-methanol;BOC-PIC(4)-OL;BUTTPARK 75\50-52;N-Boc-4-piperidineMe;Boc-4-Piperidine methanol;N-BOC-piperidin-4-Methanol;N-BOC-4-PIPERIDINEMETHANOL;BOC-ISONICOT(HEXAHYDRO)-OL;1-BOC-4-PIPERIDINEMETHANOL
CBNumber:
CB2100290
Molecular Formula:
C11H21NO3
Molecular Weight:
215.29
MDL Number:
MFCD02094488
MOL File:
123855-51-6.mol
MSDS File:
SDS
Last updated:2024-03-19 13:53:49

N-Boc-4-piperidinemethanol Properties

Melting point 78-82 °C (lit.)
Boiling point 308.0±15.0 °C(Predicted)
Density 1.059±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form Powder
pka 14.94±0.10(Predicted)
color White to brown
InChI InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
InChIKey CTEDVGRUGMPBHE-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC(CO)CC1
CAS DataBase Reference 123855-51-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
2 0

N-Boc-4-piperidinemethanol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 556017 N-Boc-4-piperidinemethanol 97% 123855-51-6 5g $138 2023-06-20 Buy
TCI Chemical B2364 1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC) 123855-51-6 1g $17 2024-03-01 Buy
TCI Chemical B2364 1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC) 123855-51-6 5g $32 2024-03-01 Buy
Alfa Aesar H26650 1-Boc-4-piperidinemethanol, 97% 123855-51-6 5g $95.65 2024-03-01 Buy
Alfa Aesar H26650 1-Boc-4-piperidinemethanol, 97% 123855-51-6 1g $28 2021-12-16 Buy
Product number Packaging Price Buy
556017 5g $138 Buy
B2364 1g $17 Buy
B2364 5g $32 Buy
H26650 5g $95.65 Buy
H26650 1g $28 Buy

N-Boc-4-piperidinemethanol Chemical Properties,Uses,Production

Chemical Properties

White to light brown solid

Uses

N-Boc-4-piperidinemethanol is an important piperidine derivative, which can be used in organic synthesis and pharmaceutical intermediates, It may be used to synthesize:
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
N-Boc-4-piperidinecarboxaldehyde
[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.

Application

N-Boc-4-piperidinemethanol is a curcumin analogue that binds to the epidermal growth factor receptor (EGFR) and prevents the binding of ligands. In vitro studies have shown that it can inhibit tumor growth and induce apoptosis in cancer cells. The drug is also capable of inhibiting the proliferation of normal cells, which may be due to its ability to recruit EGFR from outside the cell membrane. This process triggers signaling events that lead to cell death.

General Description

N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.

584-08-7
84358-13-4
123855-51-6
Synthesis of N-Boc-4-piperidinemethanol from Potassium carbonate and N-BOC-piperidine-4-carboxylic acid
Global( 490)Suppliers
Supplier Tel Email Country ProdList Advantage
Siyang Liaoning Biochemical Products Co. Ltd
+8615221114306 2594582574@qq.com China 574 58
Anhui Yiao New Material Technology Co., Ltd
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Anhui Dexinjia Biopharm Co., Ltd
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Shanghai Affida new material science and technology center
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Frapp's ChemicalNFTZ Co., Ltd.
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Capot Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58

View Lastest Price from N-Boc-4-piperidinemethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-BOC-4-piperidinemethanol pictures 2024-03-19 N-BOC-4-piperidinemethanol
123855-51-6
US $0.00-0.00 / kg 1kg 99 50000KG/month Shanghai Affida new material science and technology center
N-Boc-4-piperidinemethanol pictures 2024-02-26 N-Boc-4-piperidinemethanol
123855-51-6
US $0.00-0.00 / kg 1kg 98% Tons BTC Nantong Pharmaceuticals Technology Co.,Ltd
N-Boc-4-piperidineMethanol pictures 2023-12-20 N-Boc-4-piperidineMethanol
123855-51-6
US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
1-N-BOC-4-HYDROXYMETHYL-PIPERIDINE 1-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE 1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL TERT-BUTYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-T-BUTOXYCARBONYL-HEXAHYDROISONICOTINOL N-T-BUTOXYCARBONYL-4-HYDROXYMETHYL-PIPERIDINE N-T-BUTOXYCARBONYL-4-PIPECOLINOL N-T-BUTOXYCARBONYL-4-PIPERIDINEMETHANOL N-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE N-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL 1-Boc-4-(hydroxymethyl)piperidine 1-Boc-4-piperidinemethanol 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine N-Boc-4-piperidineMe 1-piperidinecarboxylic acid, 4-(hydroxymethyl)-, 1,1-dimet N-Boc-4-piperidinemethanol ,97% N-Boc-4-piperidinemethanol,N-tert-Butyloxycarbonyl-4-piperidinemethanol 4-(Hydroxymethyl)piperidine, N-BOC protected 97% 1-Boc-4-(hydroxymethyl)-p... tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine t-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate tert-butyl 4-(hydroxyMethyl)piperidin-1-carboxylate N-BOC-piperidin-4-Methanol N-Boc-4-piperidineMethanol, 95+% N - bok - 4 - piperidine Methanol 1-Boc-4-piperidinemethanol Synonyms N-tert-Butyloxycarbonyl-4-piperidinemethanol N-Boc-4-piperidinemethanol 97% 1,1-Dimethylethyl 4-(hydroxymethyl)-1-piperidinecarboxylate n-tert-butyloxycarbonyl-4-piperidinemethanol N-BOC-4-HYDROXYLMETHYLENE-PIPERIDINE N-BOC-4-HYDROXYMETHYLPIPERIDINE N-BOC-4-PIPERIDINEMETHANOL 1-N-Boc-4-piperidinemethanol tert-Butyl 4-(hydroxymethyl)-1-piperidinecarboxylate 1-(TERT-BUTOXYCARBONYL)-4-PYRROLIDINEMETHANOL (1-Boc-Piperidin-4-yl)methanol 1-TERT-BUTOXYCARBONYL-4-PIPERIDINEMETHANOL, N-BOC-4-PIPERIDINEMETHANOL N-BOC-4-HYDROXYMETHYLPIPERDINE N-(tert-Butoxycarbonyl)-4-(Hydroxymethyl)piperidine, 98 % 1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, 1,1-dimethylethyl ester 1-Boc-4-Hyroxymethyl-Piperidine 4-Hydroxylmethyl-N-( tert-butylcarboxylate)piperidine BUTTPARK 75\50-52 BOC-PIC(4)-OL BOC-ISONICOT(HEXAHYDRO)-OL 4-HYDROXYMETHYL-1-TERT-BUTOXYCARBONYLPIPERIDINE 4-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(HYDROXYMETHYL)PIPERIDINE-N-BOC PROTECTED 1-BOC-4-(HYDROXYMETHYL)PIPERIDINE 1-BOC-4-PIPERIDINEMETHANOL tert-Butyl 4-(hydroxymethyl)-1 1-(tert-Butoxycarbonyl)-4-piperidinemethanol > Boc-4-Piperidine methanol N-Boc-4-piperidinyl alcohol N-Boc 4-piperdine methanol N-Boc-4-piperidinemethanol 123855-51-6 TERT-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE N-BOC-piperidine-4-methanol 4-Hydroxymethyl-piperidin-1-carboxylic acid tert-butyl ester 123855-51-6