Obatoclax mesilate
- CAS No.
- 803712-79-0
- Chemical Name:
- Obatoclax mesilate
- Synonyms
- Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
- CBNumber:
- CB21011539
- Molecular Formula:
- C20H19N3O.CH4O3S
- Molecular Weight:
- 413.49
- MDL Number:
- MFCD18074508
- MOL File:
- 803712-79-0.mol
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | solid |
| color | Purple |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | 39200FJ43J |
| NCI Dictionary of Cancer Terms | obatoclax mesylate |
| NCI Drug Dictionary | obatoclax mesylate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H301 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
Obatoclax mesilate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11499 | Obatoclax (mesylate) ≥98% | 803712-79-0 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 11499 | Obatoclax (mesylate) ≥98% | 803712-79-0 | 5mg | $180 | 2024-03-01 | Buy |
| Cayman Chemical | 11499 | Obatoclax (mesylate) ≥98% | 803712-79-0 | 10mg | $330 | 2024-03-01 | Buy |
| Cayman Chemical | 11499 | Obatoclax (mesylate) ≥98% | 803712-79-0 | 50mg | $893 | 2024-03-01 | Buy |
| Tocris | 6539 | Obatoclaxmesylate ≥98%(HPLC) | 803712-79-0 | 50 | $730 | 2021-12-16 | Buy |
Obatoclax mesilate Chemical Properties,Uses,Production
Description
Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.
Chemical Properties
Red powder
Uses
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
Uses
Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.
storage
Store at -20°C
References
1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409
Obatoclax mesilate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from Obatoclax mesilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Obatoclax mesilate
803712-79-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
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- Obatoclax mesilate
803712-79-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co