Pipobroman
- CAS No.
- 54-91-1
- Chemical Name:
- Pipobroman
- Synonyms
- Amedel;A-8103;Vercyte;NSC-25154;Pipobroman;1,4-Bis(3-bromopropionyl)piperazine;1,4-Bis(3-bromo-1-oxopropyl)piperadine;1,4-Bis(3-bromo-1-oxopropyl)piperazine;1,1'-(1,4-Piperazinediyl)bis[3-bromo]-1-propanone;1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
- CBNumber:
- CB21016761
- Molecular Formula:
- C10H16Br2N2O2
- Molecular Weight:
- 356.05
- MDL Number:
- MFCD00866372
- MOL File:
- 54-91-1.mol
- MSDS File:
- SDS
| Melting point | 106-107℃ |
|---|---|
| Boiling point | 487℃ |
| Density | 1.691 |
| refractive index | 1.6220 (estimate) |
| Flash point | 248℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | -0.56±0.70(Predicted) |
| color | Crystals from H2O |
| FDA UNII | 6Q99RDT97R |
| Proposition 65 List | Pipobroman |
| ATC code | L01AX02 |
| EPA Substance Registry System | Pipobroman (54-91-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H351-H361 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 orl-rat: 220 mg/kg IYKEDH 4,467,73 |
Pipobroman price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3602 | Pipobroman ≥98% (HPLC) | 54-91-1 | 10MG | $69 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3602 | Pipobroman ≥98% (HPLC) | 54-91-1 | 50MG | $279 | 2024-03-01 | Buy |
| TRC | P490600 | Pipobroman | 54-91-1 | 1g | $320 | 2021-12-16 | Buy |
| Matrix Scientific | 099654 | 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one) 95+% | 54-91-1 | 5g | $975 | 2021-12-16 | Buy |
| Matrix Scientific | 099654 | 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one) 95+% | 54-91-1 | 10g | $1650 | 2021-12-16 | Buy |
Pipobroman Chemical Properties,Uses,Production
Originator
Vercyte ,Abbott ,US ,1966
Uses
diuretic, antihypertensive
Definition
ChEBI: Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an antineoplastic agent and an alkylating agent. It is a N-acylpiperazine, a tertiary carboxamide and an organobromine compound.
Manufacturing Process
To a solution of 17.2 g (0.10 mol) of 3-bromopropionyl chloride in 100 ml of anhydrous benzene was added dropwise with stirring a solution of 8.6 g (0.10 mol) of anhydrous piperazine in 20 ml of dry chloroform over a period of 30 minutes. The temperature rose spontaneously to 45°C during the addition. After the temperature ceased to rise, stirring was continued for another hour. The reaction mixture was then filtered to remove the piperazine hydrochloride by-product. The filtrate was evaporated to dryness and the residue recrystallized from ethanol to obtain the desired N,N'-bis-(3bromopropionyl)piperazine as a white crystalline solid melting at 103°C to 104°C. The identity of the product was further established by elemental analysis.
brand name
Vercyte (Abbott).
Therapeutic Function
Antineoplastic
Safety Profile
Poison by ingestion,subcutaneous and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects.Human mutation data reported. When heated todecomposition it emits very toxic fumes of Br- and NOx.
Pipobroman Preparation Products And Raw materials
Pipobroman Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | sales@zhiwe.net | China | 587 | 61 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Supplier | Advantage |
|---|---|
| Career Henan Chemica Co | 58 |
| Shaanxi Didu New Materials Co. Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| ZHIWE CHEMTECH CO LTD | 61 |
| LGM Pharma | 70 |
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