HOLO-TRANSFERRIN | 11096-37-0

HOLO-TRANSFERRIN Properties

storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
Water Solubility	Soluble in water (50 mg/ml).
CAS DataBase Reference	11096-37-0
EPA Substance Registry System	Transferrin (11096-37-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P264
Hazard Codes	B,Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
F	21
TSCA	Yes
HS Code	3002120000

HOLO-TRANSFERRIN price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T3915	Transferrin-biotin labeled human lyophilized powder containing sodium citrate	11096-37-0	5MG	$208	2024-03-01	Buy
Sigma-Aldrich	T3705	Transferrin human recombinant, expressed in rice	11096-37-0	1G	$636	2024-03-01	Buy
Sigma-Aldrich	T3705	Transferrin human recombinant, expressed in rice	11096-37-0	5G	$2970	2024-03-01	Buy
Sigma-Aldrich	T1428	apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%	11096-37-0	50MG	$108	2024-03-01	Buy
Sigma-Aldrich	T1428	apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%	11096-37-0	100MG	$158	2024-03-01	Buy

Product number	Packaging	Price	Buy
T3915	5MG	$208	Buy
T3705	1G	$636	Buy
T3705	5G	$2970	Buy
T1428	50MG	$108	Buy
T1428	100MG	$158	Buy

HOLO-TRANSFERRIN Chemical Properties,Uses,Production

Description

Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.

Uses

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.

Uses

Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media.

Uses

Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Definition

ChEBI: Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.

General Description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Pharmaceutical Applications

Transferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+, as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated phenol groups, a carboxylate and a carbonato ligand.

Biochem/physiol Actions

Studies have shown that co-treatment of breast cancer cells with holo-transferrin, which increases iron levels within cells and derivatives of artemisinin results in increased cell death.

Purification Methods

This transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.]

References

https://en.wikipedia.org/wiki/Transferrin
http://www.prospecbio.com/Holo_Transferrin_Human_11_121/

HOLO-TRANSFERRIN Preparation Products And Raw materials

Raw materials

Preparation Products

HOLO-TRANSFERRIN Suppliers

Global( 202)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Duly Biotech Co.,Ltd	+undefined18013301590	melody@njduly.com	China	2452	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29576	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5984	58

Supplier	Advantage
Nanjing Duly Biotech Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Wuhan Fortuna Chemical Co., Ltd	58

View Lastest Price from HOLO-TRANSFERRIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-26	HOLO-TRANSFERRIN 11096-37-0	US $30.00-3.00 / kg	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.
2023-09-06	HOLO-TRANSFERRIN 11096-37-0	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.
2019-07-14	HOLO-TRANSFERRIN 11096-37-0	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

HOLO-TRANSFERRIN
11096-37-0
US $30.00-3.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

HOLO-TRANSFERRIN
11096-37-0
US $0.00-0.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

HOLO-TRANSFERRIN
11096-37-0
US $1.00 / KG
99%
Career Henan Chemical Co

11096-37-0(HOLO-TRANSFERRIN)Related Search:

Joro toxin Ferritin INVERTOSE Transglutaminase Recombinant human lactoferrin

Epidermal Growth Factor INSULIN Transferrin receptor 2 antibody Transferrin(Serum Loading Control) Transferrin(1F10)

Rabbit Anti-TFRC antibody Ferric acetylacetonate PHENYLSELENOL SALCOMINE Tris(2,4-pentanedionato)chroMiuM(III)

2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE COBALT(II) ACETYLACETONATE

1of4

HUMAN TRANSFERRIN HUMAN TRASFERRIN HUMAN SEROTRANSFERRIN HUMAN APO-TRANSFERRIN HUMAN HOLO-TRANSFERRIN HOLO-TRANSFERRIN HOLO-TRANSFERRIN BOVINE HOLO-TRANSFERRIN HUMAN APO-TRANSFERRIN APO-TRANSFERRIN HUMAN APO-TRANSFERRIN HUMAN GAMMA-IRRADIATED*C ELL CULTURE APO-TRANSFERRIN HUMAN PARTIALLY*IRON-SAT URATED TRANSFERRIN, HUMAN, 98%, LOW ENDOTOXIN, PARTIALY SA APO-TRANSFERRIN RABBIT APPROX. 98% APO-TRANSFERRIN SHEEP APO-TRANSFERRIN RAT HOLO-TRANSFERRIN,HUMAN, APPROX. 97% ENDO TOXIN TESTED, CELL CULTURE TESTED APO-TRANSFERRIN, HUMAN, APPROX 97% ENDOT OXIN TESTED, CELL CULTURE TESTED TRANSFERRIN BOVINE HOLO-FORM*IRON-SATURA TED CELL CU APO-TRANSFERRIN DOG APO-TRANSFERRIN, BOVINE, CELL*CULTURE TE STED Transferrin,Horse,~96% Transferrin,Human,~94% APO-TRANSFERRIN (FROM HUMAN SERUM) siderophilin, partially saturated siderophilin,partially saturated APO-TRANSFERRIN,POWDER TRANSFERRIN (HOLO), FROM HUMAN PLASMA, PYROGEN-FREE transferrin (serum) Human transferrin, Siderophilin apo-Transferrin from guinea pig apo-Transferrin from sheep Siderophilin, iron-saturated, Siderophilin apo-Transferrin from rabbit apo-Transferrin from rat Holotransferrins Muscle trophic factor PARTIALLY IRON-LOADED SIDEROPHILIN Transferrin, Apo-, Tissue Culture Grade, Human Plasma Transferrin, Holo, TC Grade, Pyrogen-Free, Human Plasma apo-Transferrin from mouse Transferrin, from Rat apo-Transferrin human,Human transferrin, Siderophilin holo-Transferrin human,Siderophilin, iron-saturated Transferrin human,Siderophilin, partially saturated SIDEROPHILIN, IRON-POOR SIDEROPHILIN, IRON-POOR HUMAN SIDEROPHILIN, IRON-SATURATED SIDEROPHILIN, IRON-SATURATED HUMAN SIDEROPHILIN, PARTIALLY SATURATED HUMAN TRANSFERRIN BOVINE (APO) TRANSFERRIN BOVINE (APO FORM) TRANSFERRIN BOVINE (HOLO FORM) TRANSFERRIN (HUMAN BLOOD) TRANSFERRIN HUMAN (HOLO) TRANSFERRIN (APO) TRANSFERRIN, APO-, HUMAN