ChemicalBook >> CAS DataBase List >>ethyl 2-phenylpyrimidine-5-carboxylate

ethyl 2-phenylpyrimidine-5-carboxylate

ethyl 2-phenylpyrimidine-5-carboxylate structure

CAS No.: 85386-14-7

Chemical Name:: ethyl 2-phenylpyrimidine-5-carboxylate

Synonyms: 5-Carbethoxy-2-phenylpyrimidine;Ethyl 2-phenyl-5-pyrimidinecarboxylate;ethyl 2-phenylpyrimidine-5-carboxylate;2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER;5-Pyrimidinecarboxylic acid, 2-phenyl-, ethyl ester;ethyl 2-phenylpyrimidine-5-carboxylate ISO 9001：2015 REACH

CBNumber:: CB21079700

Molecular Formula:: C13H12N2O2

Molecular Weight:: 228.25

MDL Number:: MFCD09863207

MOL File:: 85386-14-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
Ethyl2-phenylpyrimidine-5-carboxylate	3246AC	250mg	$177
Ethyl 2-phenylpyrimidine-5-carboxylate >95%	058656	500mg	$261
Ethyl 2-phenylpyrimidine-5-carboxylate >95%	058656	1g	$327
ETHYL 2-PHENYLPYRIMIDINE-5-CARBOXYLATE 95.00%	CHM0097262	500MG	$720.84
ETHYL 2-PHENYLPYRIMIDINE-5-CARBOXYLATE 95.00%	CHM0097262	1G	$771.89

Request For Quotation

ethyl 2-phenylpyrimidine-5-carboxylate Properties

Melting point	93-95 °C
Boiling point	297.7±23.0 °C(Predicted)
Density	1.167
storage temp.	Sealed in dry,Room Temperature
pka	-0.60±0.22(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

HazardClass	IRRITANT

ethyl 2-phenylpyrimidine-5-carboxylate price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	3246AC	Ethyl2-phenylpyrimidine-5-carboxylate	85386-14-7	250mg	$177	2021-12-16	Buy
Matrix Scientific	058656	Ethyl 2-phenylpyrimidine-5-carboxylate >95%	85386-14-7	500mg	$261	2021-12-16	Buy
Matrix Scientific	058656	Ethyl 2-phenylpyrimidine-5-carboxylate >95%	85386-14-7	1g	$327	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0097262	ETHYL 2-PHENYLPYRIMIDINE-5-CARBOXYLATE 95.00%	85386-14-7	500MG	$720.84	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0097262	ETHYL 2-PHENYLPYRIMIDINE-5-CARBOXYLATE 95.00%	85386-14-7	1G	$771.89	2021-12-16	Buy

Product number	Packaging	Price	Buy
3246AC	250mg	$177	Buy
058656	500mg	$261	Buy
058656	1g	$327	Buy
CHM0097262	500MG	$720.84	Buy
CHM0097262	1G	$771.89	Buy

ethyl 2-phenylpyrimidine-5-carboxylate Chemical Properties,Uses,Production

Synthesis

ETHYL 4-CHLORO-2-PHENYL-5-PYRIMIDINECARBOXYLATE

24755-82-6

85386-14-7

General procedure for the synthesis of ethyl 2-phenylpyrimidine-5-carboxylate from ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate: Under argon protection, anhydrous ethanol (5 mL), sodium metal (0.426 g, 18.5 mmol), benzylcarbamidine hydrochloride (2.90 g, 18.5 mmol), and diethyl 2-(ethoxymethylene)malonate were added sequentially to a round-bottomed flask ( 4.0 g, 18.5 mmol). The reaction mixture was stirred at room temperature for 9 h and subsequently poured into ice water. The precipitate was collected by filtration, washed with cold water and recrystallized in a solvent mixture of EtOH-MeOH-CHCl3 (1:1:1, 45 mL) to afford ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate (8) as a white crystalline solid in 50% yield. Compound 8 (1.2 g, 4.91 mmol) was refluxed with POCl3 (9.8 g, 63.9 mmol) at 100 °C for 1 hour. Upon completion of the reaction, the excess POCl3 was removed in vacuum, the reaction mixture was poured into ice water, filtered and washed with cold water to afford chloride 9 as a white amorphous solid in 98% yield. Subsequently, chloride 9 was stirred with zinc powder (0.176 g, 2.69 mmol, 4 eq.) in anhydrous THF (2 mL) at 60 °C for 1 h. Then 5 drops of acetic acid were added. After continued stirring at 60 °C for 23 h, the reaction mixture was cooled to room temperature, CH2Cl2 (3 mL) was added, filtered and the solvent was evaporated. Purification by silica gel column chromatography (n-hexane-EtOAc, 0.6%) afforded ethyl 2-phenylpyrimidine-5-carboxylate as a white crystalline solid in 50% yield.

References

[1] Molecules, 2013, vol. 18, # 10, p. 11683 - 11704
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983, vol. 32, # 2, p. 265 - 270
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983, # 2, p. 299 - 304

ethyl 2-phenylpyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 2-chloropyrimidine-5-carboxylate ETHYL 4-CHLORO-2-PHENYL-5-PYRIMIDINECARBOXYLATE Benzamidine hydrochloride Ethyl 3-dimethylamino-2-formylacrylate Phenylboronic acid

ZINC Acetic acid

1of2

Preparation Products

ethyl 2-phenylpyrimidine-5-carboxylate Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53802	58
Nanjing Moldeep Biochemical Co., Ltd.	+86-25-58282389 +8618913958656	inquiries@moldeep.com	China	19981	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	21-57721279 18121011378	sales@shydchem.com.cn	China	998	56
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10186	62

Supplier	Advantage
Alchem Pharmtech,Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Nanjing Moldeep Biochemical Co., Ltd.	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	56
Pure Chemistry Scientific Inc.	62

View Lastest Price from ethyl 2-phenylpyrimidine-5-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	ethyl 2-phenylpyrimidine-5-carboxylate 85386-14-7	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

ethyl 2-phenylpyrimidine-5-carboxylate
85386-14-7
US $1.10 / g
99.00%
Dideu Industries Group Limited

ethyl 2-phenylpyrimidine-5-carboxylate Spectrum

ethyl 2-phenylpyrimidine-5-carboxylate(85386-14-7)¹HNMR

85386-14-7(ethyl 2-phenylpyrimidine-5-carboxylate)Related Search:

ETHYL 4-ETHOXY-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-CHLORO-2-PHENYL-5-PYRIMIDINECARBOXYLATE Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate ETHYL 2-PHENYL-4-(1,4-THIAZINAN-4-YL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-[(4-CHLOROPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE

ETHYL 4-(4-METHOXYPHENOXY)-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-(2,6-DIMETHYLMORPHOLINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-(BENZYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-PHENOXY-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-MORPHOLINO-2-PHENYL-5-PYRIMIDINECARBOXYLATE

ETHYL 2-PHENYL-4-(1-PYRROLIDINYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-[(3-CHLOROPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-[(3-METHYLPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-(CYCLOHEXYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 4-(METHYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE

ETHYL 2-PHENYL-4-(PHENYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE ETHYL 2-PHENYL-4-([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)-5-PYRIMIDINECARBOXYLATE

1of4

ethyl 2-phenylpyrimidine-5-carboxylate 2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER 5-Carbethoxy-2-phenylpyrimidine 5-Pyrimidinecarboxylic acid, 2-phenyl-, ethyl ester ethyl 2-phenylpyrimidine-5-carboxylate ISO 9001：2015 REACH Ethyl 2-phenyl-5-pyrimidinecarboxylate 85386-14-7