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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile structure

CAS No.: 143782-23-4

Chemical Name:: 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

Synonyms: 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;D3-EZ-S2;4-Isothiocyanato-2;Enzalutamide Impurity Z;Enzalutamide Impurity 21;Enzalutamide Impurity N7;Enzalutamide intermediate;-Fluoro-4-methylphenylisothiocyanate;4-isothiocyano-2 -(trixenon methyl) benzol;4-cyano-3-trifluoromenthylphenylisothiocyanate

CBNumber:: CB21107300

Molecular Formula:: C9H3F3N2S

Molecular Weight:: 228.19

MDL Number:: MFCD09800709

MOL File:: 143782-23-4.mol

MSDS File:: SDS

Last updated:2023-08-21 17:53:15

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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Properties

Melting point	39.0 to 43.0 °C
Boiling point	331℃
Density	1.31
Flash point	154℃
solubility	Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
form	powder to lump
color	White to Yellow to Green
Stability	Hygroscopic, Moisture sensitive
InChI	InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
InChIKey	TYXKOMAQTWRDCR-UHFFFAOYSA-N
SMILES	C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
CAS DataBase Reference	143782-23-4
FDA UNII	HP6388MX6K

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H227

Precautionary statements

P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235

HS Code

2929100090

NFPA 704

	0
2		0

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	I0987	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile >98.0%(GC)	143782-23-4	1g	$70	2024-03-01	Buy
TCI Chemical	I0987	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile >98.0%(GC)	143782-23-4	5g	$201	2024-03-01	Buy
TRC	C987640	4-Cyano-3-trifluoromethylphenylisothiocyanate	143782-23-4	10g	$1260	2021-12-16	Buy
Matrix Scientific	120962	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 97%	143782-23-4	250g	$1980	2021-12-16	Buy
Matrix Scientific	120962	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 97%	143782-23-4	500g	$2880	2021-12-16	Buy

Product number	Packaging	Price	Buy
I0987	1g	$70	Buy
I0987	5g	$201	Buy
C987640	10g	$1260	Buy
120962	250g	$1980	Buy
120962	500g	$2880	Buy

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties,Uses,Production

Uses

4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents.

Uses

4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.

Synthesis

Synthesis_143782-23-4
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile synthesis

Synthesis of 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile from Thiophosgene and 4-Amino-2-(trifluoromethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile Enzalutamide

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Suppliers

Global( 411)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Innopharm Industrial Co., Ltd.	+86-21-59960785 +86-17701845089	sales@hoyaopharm.com	China	261	58
AstaTech(Chengdu) Biopharmaceutical Corp.	+86-02882666559 +86-15884417729	gjpu@astatech.com.cn	China	308	58
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1001	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-0531-69954981 +8615666777973	dwyane.wang@boyuanpharm.com	China	211	58
Suzhou Chukai Pharma Tech Co.,Ltd	+8615062531973	2279973922@qq.com	China	224	58
Shanghai Famo Biotech Co Ltd	+86-36680037 +86-18550473860	mayan@famobiotech.com;sales@famobiotech.com	China	503	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	248	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	204	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58

Supplier	Advantage
Shanghai Innopharm Industrial Co., Ltd.	58
AstaTech(Chengdu) Biopharmaceutical Corp.	58
Hangzhou Verychem Science And Technology Co.Ltd	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
Suzhou Chukai Pharma Tech Co.,Ltd	58
Shanghai Famo Biotech Co Ltd	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

View Lastest Price from 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 143782-23-4	US $3.20-266.00 / g	1g	99%	10kg	Wuhan Cell Pharmaceutical Co., Ltd
2024-04-10	4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 143782-23-4	US $0.00 / kg	1kg	95%	2Tons	Shanghai Joiny Pharmaceutical Co.,LTD
2023-11-09	4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 143782-23-4	US $10.00 / g	1g	99%	10tons	qingdao future trading Co., Ltd

4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
143782-23-4
US $3.20-266.00 / g
99%
Wuhan Cell Pharmaceutical Co., Ltd

4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
143782-23-4
US $0.00 / kg
95%
Shanghai Joiny Pharmaceutical Co.,LTD

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
143782-23-4
US $10.00 / g
99%
qingdao future trading Co., Ltd

143782-23-4( 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile)Related Search:

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Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)- 3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-cyano-3-trifluoromenthylphenylisothiocyanate 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate 4-isothiocyananto-2-(trifluoromethyl) benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE/4-CYANO-3-TRIFLUOROMETHYLPHENYLISOTHIOCYANATE /CAS NO: 143782-23-4 Enzalutamide intermediate Enzalutamide Impurity Z Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzeneQ: What is Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the CAS Number of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the storage condition of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What are the applications of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene 4-Isothiocyanato-2 Isothiocyanato-2-(trifluoromethyl)benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE (CAS : 143782-23-4) (intermediate of Enzalutamide) 4-isothiocyanoyl-2 - (trifluoromethyl) benzonitrile Enzalutamide Impurity 21 Isothiocyanic Acid 4-Cyano-3-(trifluoromethyl)phenyl Ester 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-isothiocyano-2 - (trifluoromethyl) benzonitrile 4-isothiolamino-2-(trifluoromethyl)benzene Melonitrile -Fluoro-4-methylphenylisothiocyanate 4-Cyano-3-(trifluoromethyl)phenylIsothiocyanate,98% 4-isothiocyano-2 -(trixenon methyl) benzol Enzalutamide Impurity N7 4-cyano-3-trifluoromenthylphenylisothiocyaChemicalbooknate 4-Isothiocvanato-2-(trifluoromethyl)benzonitrile D3-EZ-S2 143782-23-4 123782-23-4 143782-23-4