ChemicalBook >> CAS DataBase List >> 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

CAS No.
143782-23-4
Chemical Name:
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
Synonyms
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;4-Isothiocyanato-2;Enzalutamide Impurity Z;Enzalutamide Impurity 21;Enzalutamide Impurity N7;Enzalutamide intermediate;-Fluoro-4-methylphenylisothiocyanate;4-isothiocyano-2 -(trixenon methyl) benzol;4-cyano-3-trifluoromenthylphenylisothiocyanate;Isothiocyanato-2-(trifluoromethyl)benzonitrile
CBNumber:
CB21107300
Molecular Formula:
C9H3F3N2S
Molecular Weight:
228.19
MDL Number:
MFCD09800709
MOL File:
143782-23-4.mol
MSDS File:
SDS
Last updated:2023-08-21 17:53:15

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Properties

Melting point 39.0 to 43.0 °C
Boiling point 331℃
Density 1.31
Flash point 154℃
solubility Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
form powder to lump
color White to Yellow to Green
Stability Hygroscopic, Moisture sensitive
InChI InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
InChIKey TYXKOMAQTWRDCR-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
CAS DataBase Reference 143782-23-4
FDA UNII HP6388MX6K

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H227
Precautionary statements  P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
HS Code  2929100090
NFPA 704
0
2 0

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical I0987 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile >98.0%(GC) 143782-23-4 1g $70 2023-06-20 Buy
TCI Chemical I0987 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile >98.0%(GC) 143782-23-4 5g $201 2023-06-20 Buy
TRC C987640 4-Cyano-3-trifluoromethylphenylisothiocyanate 143782-23-4 10g $1260 2021-12-16 Buy
AK Scientific J53800 4-Cyano-3-(trifluoromethyl)phenylisothiocyanate 143782-23-4 1g $60 2021-12-16 Buy
SynQuest Laboratories 7849-3-01 4-Cyano-3-(trifluoromethyl)phenyl isothiocyanate 143782-23-4 1g $189 2021-12-16 Buy
Product number Packaging Price Buy
I0987 1g $70 Buy
I0987 5g $201 Buy
C987640 10g $1260 Buy
J53800 1g $60 Buy
7849-3-01 1g $189 Buy

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties,Uses,Production

Uses

4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents.

Uses

4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.

Synthesis

Synthesis_143782-23-4
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).

463-71-8
654-70-6
143782-23-4
Synthesis of 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile from Thiophosgene and 4-Amino-2-(trifluoromethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials

Global( 385)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Innopharm Industrial Co., Ltd.
+86-21-59960785 +86-17701845089 sales@hoyaopharm.com China 261 58
AstaTech(Chengdu) Biopharmaceutical Corp.
+86-02882666559 +86-15884417729 gjpu@astatech.com.cn China 308 58
Hangzhou Verychem Science And Technology Co.Ltd
571-88162785 +8613606544505 lucy@verychem.com China 950 58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
+86-0531-69954981 +8615666777973 dwyane.wang@boyuanpharm.com China 211 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580 +86-13176845580 da@zhongda-biotech.com China 248 58
Anhui Zhongda Biotechnology Co., Ltd
+8615689548120 linda@zhongda-biotech.com China 204 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29767 60
Henan DaKen Chemical CO.,LTD.
+86-0371-66670886 info@dakenchem.com China 14701 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21719 55

View Lastest Price from 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile pictures 2023-11-09 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
143782-23-4
US $10.00 / g 1g 99% 10tons qingdao future trading Co., Ltd
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile pictures 2023-11-03 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
143782-23-4
US $0.00 / kg 1kg 95% 2Tons Shanghai Joiny Pharmaceutical Co.,LTD
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile pictures 2023-11-01 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
143782-23-4
US $0.00 / kg 1kg 99.0%min 5MT Hangzhou ICH Biofarm Co., Ltd
Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)- 3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-cyano-3-trifluoromenthylphenylisothiocyanate 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate 4-isothiocyananto-2-(trifluoromethyl) benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE/4-CYANO-3-TRIFLUOROMETHYLPHENYLISOTHIOCYANATE /CAS NO: 143782-23-4 Enzalutamide intermediate Enzalutamide Impurity Z Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzeneQ: What is Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the CAS Number of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the storage condition of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What are the applications of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene 4-Isothiocyanato-2 Isothiocyanato-2-(trifluoromethyl)benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE (CAS : 143782-23-4) (intermediate of Enzalutamide) 4-isothiocyanoyl-2 - (trifluoromethyl) benzonitrile Enzalutamide Impurity 21 Isothiocyanic Acid 4-Cyano-3-(trifluoromethyl)phenyl Ester 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-isothiocyano-2 - (trifluoromethyl) benzonitrile 4-isothiolamino-2-(trifluoromethyl)benzene Melonitrile -Fluoro-4-methylphenylisothiocyanate 4-Cyano-3-(trifluoromethyl)phenylIsothiocyanate,98% 4-isothiocyano-2 -(trixenon methyl) benzol Enzalutamide Impurity N7 4-cyano-3-trifluoromenthylphenylisothiocyaChemicalbooknate 143782-23-4 123782-23-4 143782-23-4