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Ceftriaxone sodium

Ceftriaxone sodium
Ceftriaxone sodium structure
CAS No.
74578-69-1
Chemical Name:
Ceftriaxone sodium
Synonyms
rocephin;x13-9904;ro13-9904;Longaceph;beta(z)))-;CEFATRIAXONE;cephtriaxone;Ceftriaxone sodium;cefatriaxonehydrate;Ceftriaxone disodium
CBNumber:
CB2114534
Molecular Formula:
C18H18N8O7S3
Formula Weight:
554.58
MOL File:
74578-69-1.mol

Ceftriaxone sodium Properties

CAS DataBase Reference
74578-69-1(CAS DataBase Reference)
FDA UNII
023Z5BR09K

Ceftriaxone sodium Chemical Properties,Uses,Production

Uses

Ceftriaxone sodium is antibacteria.

brand name

Rocephin (Roche).

Hazard

Moderately toxic. Low toxicity by inges- tion. Human systemic effects.

Clinical Use

Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.

Veterinary Drugs and Treatments

Ceftriaxone is used to treat serious infections, particularly against susceptible Enterobacteriaceae that are not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity). Its long half life, good CNS penetration, and activity against Borrelia burgdorferi also has made it a potential choice for treating Lyme’s disease.

Ceftriaxone sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Ceftriaxone sodium Suppliers

Global( 216)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58

View Lastest Price from Ceftriaxone sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-23 Ceftriaxone sodium
74578-69-1
US $0.00-0.00 / 公斤 1公斤 99.0%+ 300 MT Shaanxi Dideu Medichem Co. Ltd
2019-10-29 Ceftriaxone sodium
74578-69-1
US $1.00 / Kg/Drum 25Kg/Drum 99% 1ton HubeiwidelychemicaltechnologyCo.,Ltd
2018-12-17 Ceftriaxone sodium
74578-69-1
US $1.00 / kg 1kg 99% 100KG career henan chemical co

74578-69-1(Ceftriaxone sodium)Related Search:


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  • 99% CAS 74578-69-1 Pharmaceutical Raw Materials Ceftriaxone sodium
  • beta(z)))-
  • cefatriaxonehydrate
  • cephtriaxone
  • ro13-9904
  • rocephin
  • x13-9904
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, [6R-[6alpha,7beta(Z)]]-
  • CEFTRIAXONE SODIUM, USP
  • Longaceph
  • Ceftriaxone disodium
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, [6R-[6α,7β(Z)]]-
  • 74578-69-1
  • C18H18N8O7S32Na
  • C17H17N8NaO7S3
  • Pharmaceutical intermediates
  • Pharmaceutical intermediates, pharmaceutical raw materials
  • Pharmaceutical intermediate
  • Pharma
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