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Ceftriaxone sodium

Ceftriaxone sodium Structure
Ceftriaxone sodium structure
CAS No.
74578-69-1
Chemical Name:
Ceftriaxone sodium
Synonyms
Ceftriaxone disodium;rocephin;Longaceph;Ceftriaxonesodiumnon-steriled;(6R,7R)-7-[(2E)-2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-{[(2-Methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;x13-9904;ro13-9904;beta(z)))-;CEFATRIAXONE;cephtriaxone
CBNumber:
CB2114534
Molecular Formula:
C18H19N8NaO7S3
Molecular Weight:
578.57
MDL Number:
MFCD00865013
MOL File:
74578-69-1.mol
MSDS File:
SDS
Last updated:2024-03-27 17:16:15
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Ceftriaxone sodium Properties

storage temp. 4°C, protect from light
solubility Soluble in DMSO (50 mM)
color White to off-white
Water Solubility Water : ≥ 40 mg/mL (66.60 mM)
InChIKey CDCJSJLFRBHEHN-ZZKDXJNYNA-N
SMILES C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NC(=O)C(=O)NN1C)(=O)O.[NaH] |&1:5,7,r|
CAS DataBase Reference 74578-69-1(CAS DataBase Reference)
FDA UNII R598PB148Q
NCI Drug Dictionary ceftriaxone sodium

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H334-H317
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

Ceftriaxone sodium price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific K275 Ceftriaxonesodium,795ug/mg 74578-69-1 100mg $49 2021-12-16 Buy
ChemScene CS-4519 Ceftriaxone(sodiumsalt) 98.12% 74578-69-1 100mg $60 2021-12-16 Buy
ChemScene CS-4519 Ceftriaxone(sodiumsalt) 98.12% 74578-69-1 500mg $108 2021-12-16 Buy
American Custom Chemicals Corporation API0006455 CEFTRIAXONE SODIUM SALT 95.00% 74578-69-1 25MG $166.95 2021-12-16 Buy
Matrix Scientific 082924 Ceftriaxone sodium salt 97% 74578-69-1 1g $230 2021-12-16 Buy
Product number Packaging Price Buy
K275 100mg $49 Buy
CS-4519 100mg $60 Buy
CS-4519 500mg $108 Buy
API0006455 25MG $166.95 Buy
082924 1g $230 Buy

Ceftriaxone sodium Chemical Properties,Uses,Production

Description

Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic that is used to treat conditions such as lower respiratory tract infections, skin and skin structure infections, urinary tract infections, pelvic inflammatory disease, bacterial septicemia, bone and joint infections, and meningitis. 

Originator

Rocephin,Roche,Switz.,1982

Uses

Ceftriaxone sodium is antibacteria，an impurity of Ceftriaxone (C244995). It is an antibacterial, a third-generation cephalosporin.

brand name

Rocephin (Roche).

Therapeutic Function

Antibacterial

General Description

Ceftriaxone was synthesized by HoffmannLa Roche in 1981. The triazinyl moiety was introduced at the 3 position of the cephem nucleus. The same side chain as possessed by cefotaxime and the other so-called third-generation cephalosporins was retained at the 7 position. The antibacterial activity of ceftiaxone is almost the same as that of cefotaxime in vitro, but its in vivo activity is 10 to 100 times higher. Its most characteristic property is its seven to eight hour half-life in serum, the longest among the known cephem antibiotics.

Hazard

Moderately toxic. Low toxicity by inges- tion. Human systemic effects.

Mechanism of action

Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lac- tamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The β-lactam core of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell wall synthesis and cell division. By binding to these enzymes, ceftriaxone causes formation of defective cell walls and promotes cell death[1].

Clinical Use

Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.

Side effects

Ceftriaxone sodium is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.

Side effects

Common side effects of Ceftriaxone sodium include:
symptoms of a blood cell disorder;
diarrhea;
vaginal itching or discharge;
warmth, tight feeling, or a hard lump where the injection was given;
rash;
abnormal liver function tests.

Synthesis

A solution of sodium-2-ethyl hexanoate (390 g) in acetone (2.0 Ltr) is added to the wet Ceftriaxone acid obtained in Example 2 is suspended in a mixture of acetone and water. The reaction mixture is charcoalized and filtered. To the clear filtrate is added acetone whereupon the product precipitated. The precipitated solid is filtered, washed with acetone and dried to get 515 g of Ceftriaxone sodium hemiheptahydrate. HPLC purity = Above 99.5%.

Veterinary Drugs and Treatments

Ceftriaxone is used to treat serious infections, particularly against susceptible Enterobacteriaceae that are not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity). Its long half life, good CNS penetration, and activity against Borrelia burgdorferi also has made it a potential choice for treating Lyme’s disease.

storage

+4°C

References

[1] Rawls S, et al. Antibiotics, β-Lactam. Encyclopedia of the Neurological Sciences, 2014; 207-209.

Ceftriaxone sodium Preparation Products And Raw materials

Raw materials

Formic acid CARBOXYLIC ACID

Preparation Products

Ceftriaxone sodium Suppliers

Global( 351)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Excellent Biomedical Technology Co.,Ltd. 		+86-0755-26050679 +86-15915472436 sale@ex-biotech.cn China 1031 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618740459177 sarah@tnjone.com China 893 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hubei XinRunde Chemical Co., Ltd. 		+8615102730682 bruce@xrdchem.cn CHINA 566 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Supplier Advantage
Shenzhen Excellent Biomedical Technology Co.,Ltd. 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hubei XinRunde Chemical Co., Ltd. 		55
career henan chemical co 		58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58

Related articles

View Lastest Price from Ceftriaxone sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ceftriaxone sodium pictures 2024-04-07 Ceftriaxone sodium
74578-69-1
 US $10.00 / KG 1KG 99% 10t Zibo Wei Bin Import & Export Trade Co. Ltd.
Ceftriaxone Sodium pictures 2024-03-27 Ceftriaxone Sodium
74578-69-1
 US $0.00 / KG 1KG 99% 2000KG Shaanxi TNJONE Pharmaceutical Co., Ltd
Ceftriaxone sodium pictures 2024-03-16 Ceftriaxone sodium
74578-69-1
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

74578-69-1(Ceftriaxone sodium)Related Search:

Sodium acetate Sodium benzoate Tetramethylpyrazine DIOXOPROMETHAZINE HCL CEFTRIAXONE
2-Methylpyrazine Sodium carbonate CEFADROXIL Ceftizoxime sodium CeftazidiMe
Ceftriaxone sodium Sodium formate Sodium hydroxide Sodium bicarbonate Sodium gluconate
Sodium chloride Cefadroxil Cephalothin sodium

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CEFATRIAXONE 2,5,6-tetrahydro-2-methyl-5,6-dioxo-)(methoxyimino)acetyl)amino)-8-oxo-3-((( 4-triazin-3-yl)thio)methyl)-,sodiumsalt,hydrate(2:4:7)(6r-(6-alpha,7-2 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, [6R-[6α,7β(Z)]]- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, (6R,7R)- [6R-[6alpha,7beta(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt Ceftriaxone sodium Ceferiaxone SodiuM Sterile CEFTRIAXONE SODIUM NON 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-,sodiuM salt (1:2), (6R,7R)- beta(z)))- cefatriaxonehydrate cephtriaxone ro13-9904 x13-9904 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, [6R-[6alpha,7beta(Z)]]- CEFTRIAXONE SODIUM, USP 99% CAS 74578-69-1 Pharmaceutical Raw Materials Ceftriaxone sodium Ceftriaxone sodium crude product Disodium ceftriaxone sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((2-methyl-6-oxido-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Ingredients Ceftriaxone Sodium Ceftriaxone sodiumQ: What is Ceftriaxone sodium Q: What is the CAS Number of Ceftriaxone sodium Q: What is the storage condition of Ceftriaxone sodium Q: What are the applications of Ceftriaxone sodium Ceftriaxone disodium Longaceph Ceftriaxonesodiumnon-steriled (6R,7R)-7-[(2E)-2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-{[(2-Methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid rocephin 74578-69-1 C17H17N8NaO7S3 C18H18N8O7S32Na Pharmaceutical intermediates, pharmaceutical raw materials Pharmaceutical intermediates Pharma Pharmaceutical intermediate 74578-69-1