Vatalanib Dihydrochloride
- CAS No.
- 212141-51-0
- Chemical Name:
- Vatalanib Dihydrochloride
- Synonyms
- PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
- CBNumber:
- CB21176854
- Molecular Formula:
- C20H17Cl3N4
- Molecular Weight:
- 419.74
- MDL Number:
- MFCD08458964
- MOL File:
- 212141-51-0.mol
| Melting point | 268-2700C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml) |
| form | solid |
| color | White or off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 212141-51-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| HS Code | 29333990 |
Vatalanib Dihydrochloride price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2498 | Vatalanib dihydrochloride ≥98% (HPLC) | 212141-51-0 | 10mg | $76 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2498 | Vatalanib dihydrochloride ≥98% (HPLC) | 212141-51-0 | 50mg | $257 | 2024-03-01 | Buy |
| Cayman Chemical | 14868 | Vatalanib (hydrochloride) ≥98% | 212141-51-0 | 10mg | $51 | 2024-03-01 | Buy |
| Cayman Chemical | 14868 | Vatalanib (hydrochloride) ≥98% | 212141-51-0 | 25mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 14868 | Vatalanib (hydrochloride) ≥98% | 212141-51-0 | 50mg | $165 | 2024-03-01 | Buy |
Vatalanib Dihydrochloride Chemical Properties,Uses,Production
Description
Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-
Chemical Properties
White to Off-White Crystalline Powder
Uses
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.
Uses
Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.
References
1) Wood?et al. (2000),?PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;? Cancer Res.,?60?2178 2) Lin?et al. (2002),?The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;? Cancer Res.,?62?5019
Vatalanib Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29627 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9587 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from Vatalanib Dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Vatalanib Dihydrochloride
212141-51-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
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- Vatalanib Dihydrochloride
212141-51-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co