ChemicalBook
Chinese Japanese Germany Korea

Oseltamivir phosphate

Anti-influenza virus Uses
Oseltamivir phosphate
Oseltamivir phosphate structure
CAS No.
204255-11-8
Chemical Name:
Oseltamivir phosphate
Synonyms
Oselt;OseltaMir phosphate;Oseltamivir phosphat;Olstamivir Phosphate;OSELTAMIVIR PHOSPHATE;Osteltamivir phosphate;NTERMEDIATES OF OSELTAMIVIR;Oseltamivir phosphate, >=98%;OseltaMivir Acid-D3 Phosphate;Oseltamivir Phosphate (200 mg)
CBNumber:
CB2119221
Molecular Formula:
C16H31N2O8P
Formula Weight:
410.4
MOL File:
204255-11-8.mol

Oseltamivir phosphate Properties

Melting point:
196-198°C
storage temp. 
-20°C Freezer
solubility 
H2O: soluble30mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -26 to -36°, c = 1 in H2O
InChIKey
PGZUMBJQJWIWGJ-IFAKAUOZSA-N
CAS DataBase Reference
204255-11-8(CAS DataBase Reference)

SAFETY

HazardClass  IRRITANT

Oseltamivir phosphate price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1781 Oseltamivir phosphate Pharmaceutical Secondary Standard; Certified Reference Material 204255-11-8 500mg $113 2018-11-20 Buy
Sigma-Aldrich 1479304 Oseltamivir phosphate United States Pharmacopeia (USP) Reference Standard 204255-11-8 200mg $454 2018-11-13 Buy
Cayman Chemical 16070 Oseltamivir (phosphate) ≥98% 204255-11-8 250mg $93 2018-11-13 Buy
Cayman Chemical 16070 Oseltamivir (phosphate) ≥98% 204255-11-8 100mg $39 2018-11-13 Buy
Sigma-Aldrich SML1606 Oseltamivir phosphate ≥98% (HPLC) 204255-11-8 100mg $62.8 2018-11-20 Buy

Oseltamivir phosphate Chemical Properties,Uses,Production

Anti-influenza virus

Oseltamivir phosphate is a kind of anti-influenza drugs, under the trade name Tamiflu. Its appearance exhibits as white to yellowish-white powder. It can be divided into type A (alpha) and B (Beta) selective inhibitor of the influenza virus neuraminidase and can prevent the release of virus from infected cells, through inhibiting the activity of the influenza virus neuraminidase, thus achieving the purpose of control of influenza symptoms. Clinically it can be used for treatment of the type A influenza and type B influenza in adults and children of 1 year old or over 1 year old as well as the clinical prevention of influenza A and B in adult and adolescent of 13 year old or over 13 years old.
Oseltamivir phosphate can subject to rapid metabolism into oselatamivr carboxylate after gastrointestinal absorption with 75% of the total oral administrated dose participating in the systemic circulation in the from of oselatamivr carboxylate. The active ingredient of this drug is a potent and unique neuraminidase inhibitors acting on all the processes of influenza virus infection, preventing the replication of all clinically relevant influenza virus strains A or B strain. It has obvious inhibitory effect even in nanomolar concentration in vitro. It has ben observed in vitro that the active metabolite can inhibit the growth of influenza virus as well as in vivo that it can inhibit the replication and pathogenicity of influenza virus. This product, through inhibiting the release of virus from infected cells, can reduce the spread of influenza A or B virus.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Uses

Antibiotics and anti-virus

Description

Oseltamivir was launched in the US and Switzerland for the treatment of influenza infections by all common strain viruses. It can be obtained by at least 2 different ways including a novel 12-step synthesis from (-)-quinic acid. Oseltamivir is the ethyl ester prodrug of GS-4071, the corresponding acid, which is one of the most potent inhibitors of both influenza A and B virus neuraminidase (sialidase) isoenzymes; these glycoproteins are expressed on the virion surface and are essential for virus replication for both A and B strains. Oseltamivir emerged as one of the first two neuraminidase inhibitors to reach the market. GS-4071 demonstrated a low (< 5%) oral bioavailability in animals due to a poor absorption from the gastrointestinal barrier; by incorporating a more lipophilic ester group, the oral bioavailabilty can reach 30 to 100% in mice, rats and dogs. Following oral administration of Oseltamivir in rats, a similar concentration of GS-4071 was found in the bronchoalveolar lining fluid and the plasma which indicated a good penetration of the active compound into the lower respiratory tract. In mice, chickens and ferrets, orally administered Oseltamivir was found to have significant inhibitory effects on A and B influenza infections in protecting against a lethal challenge of virus and lessening virus titer in the lungs or nasal washings. In several clinical trials with patients receiving oral capsules daily, Oseltamivir was shown to be effective in reducing significantly the duration and severity of the clinical symptoms, including fever, cough and general malaise, in both early treatment and prevention.

Chemical Properties

White Cyrstalline Solid

Originator

Gilead (US)

Uses

Orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug.

Uses

Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its

Uses

An antiviral agent

brand name

Tamiflu (Roche).

General Description

receptor site showed clearly that additional binding sitesexist for the C-5 acetamido carbonyl group and the arginineresidue at position 152 of the receptor site. In addition, the C-2 carboxyl group of sialic acid binds to Arg 118, Arg 292, andArg 371. Position C-6 is capable of undergoing a hydrophobicinteraction with various amino acids, including Glu, Ala,Arg, and Ile. Maximum binding to neuraminidase occurswhen the C-6 substituent is substituted with a nonpolar chain.In oseltamivir, this nonpolar group is 3-pentyl. An importantfeature of oseltamivir is the ethyl ester, which makes the drugorally efficacious. This drug is the first orally active agent foruse against influenza A and B. It is also indicated for the treatmentof acute illness. If administered within 2 days after theonset of influenza symptoms, the drug is effective.

Oseltamivir phosphate Preparation Products And Raw materials

Raw materials

Preparation Products


Oseltamivir phosphate Suppliers

Global( 221)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 306 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24212 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6402 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58

View Lastest Price from Oseltamivir phosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-27 Oseltamivir phosphate
204255-11-8
US $15.00 / KG 1KG 98% 1000KG career henan chemical co

204255-11-8(Oseltamivir phosphate)Related Search:


  • Oseltamivir phosphate, >=98%
  • Olstamivir Phosphate
  • ethyl (3r,4r,5s)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate phosphate
  • OSELTAMIVIR PHOSPHATE
  • NTERMEDIATES OF OSELTAMIVIR
  • (3R,4R,5S)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate salt
  • Osteltamivir phosphate
  • (3R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate phosphate
  • Oseltamivir phosphat
  • Oseltamivir Phosphate (200 mg)
  • Oselt
  • OseltaMivir Acid-D3 Phosphate
  • 204255-11-8
  • C16H28N2O4H3O4P
  • C16H31N2O8P
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Ring Systems
  • Oseltamivir
  • Influenza Viruses
  • C16H28N2O4H3PO4
  • C16H27N2O4
  • OseltaMivir phosphate (TaMiflu)
  • (3R,4R,5S)-ethyl 4-acetaMido-5-aMino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate phosphate
  • OseltaMir phosphate
  • (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)--cyclohexene-1-carboxylic acid ethyl ester, phosphate (1:1)
  • Oseltamivir phosphate (impurity B free)
  • -
  • Amines
  • Anti-virals
  • apis
  • Tamiflu
Copyright 2017 © ChemicalBook. All rights reserved