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Dantrolene sodium salt

Dantrolene sodium salt Structure
Dantrolene sodium salt structure
CAS No.
14663-23-1
Chemical Name:
Dantrolene sodium salt
Synonyms
F-440;DANTRIUM;DANTROLENE NA;DantroloneSodium;dantorolenesodium;SODIUM DANTROLENE;Aantrolene Sodium;Dantrolene, sodium s;DANTROLENE SODIUM SALT;dantrolene sodium price
CBNumber:
CB2128232
Molecular Formula:
C14H11N4NaO5
Molecular Weight:
338.25
MDL Number:
MFCD00079130
MOL File:
14663-23-1.mol
Last updated:2023-06-30 15:45:59
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Dantrolene sodium salt Properties

storage temp. Store at RT
solubility Soluble in DMSO (up to 3 mg/ml)
form Orange solid
color Orange
Merck 14,2816
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
InChIKey KSRLIXGNPXAZHD-HAZZGOGXSA-M
CAS DataBase Reference 14663-23-1(CAS DataBase Reference)
FDA UNII 28F0G1E0VF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  2
RTECS  MU3875000
HS Code  2942.00.3500

Dantrolene sodium salt price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9175 Dantrolene sodium salt 14663-23-1 1g $607 2024-03-01 Buy
Sigma-Aldrich 251680 Dantrolene, Sodium Salt 14663-23-1 100mg $96.7 2024-03-01 Buy
TCI Chemical D3996 Dantrolene Sodium Salt Hydrate >98.0%(HPLC)(T) 14663-23-1 1g $124 2024-03-01 Buy
TCI Chemical D3996 Dantrolene Sodium Salt Hydrate >98.0%(HPLC)(T) 14663-23-1 5g $382 2024-03-01 Buy
Alfa Aesar J60887 Dantrolene sodium salt 14663-23-1 100mg $68.65 2024-03-01 Buy
Product number Packaging Price Buy
D9175 1g $607 Buy
251680 100mg $96.7 Buy
D3996 1g $124 Buy
D3996 5g $382 Buy
J60887 100mg $68.65 Buy

Dantrolene sodium salt Chemical Properties,Uses,Production

Description

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

Chemical Properties

mp 279-280C 3415821

Uses

Skeletal muscle relaxant;Blocker of Ca2+ release

Uses

Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

Definition

ChEBI: The anhydrous sodium salt of dantrolene.

brand name

Dantrium (Procter & Gamble).

Biological Activity

Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

storage

Store at RT

References

1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292

Dantrolene sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Dantrolene sodium salt Suppliers

Global( 243)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9702 58
Supplier Advantage
Shanghai Yingrui Biopharma Co., Ltd. 		60
career henan chemical co 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Finetech Industry Limited 		58

View Lastest Price from Dantrolene sodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dantrolene sodium salt pictures 2023-06-15 Dantrolene sodium salt
14663-23-1
 US $683.00 / Kg/Bag 1KG 99% 1T Baoji Guokang Bio-Technology Co., Ltd.
Dantrolene sodium salt hydrate pictures 2022-01-27 Dantrolene sodium salt hydrate
14663-23-1
 US $0.00 / KG 1KG 98.0% 100 tons Honest Joy Holdings Limited
Dantrolene sodium salt pictures 2021-11-02 Dantrolene sodium salt
14663-23-1
 US $634.90 / KG 1KG 99% 800kg Baoji Guokang Healthchem co.,ltd

Dantrolene sodium salt Spectrum

Dantrolene sodium salt(14663-23-1)1HNMR

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DANTROLENE SODIUM SALT 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoinsodium 1-((5-(p-nitrophenyl)furfurylidene)amino)-hydantoisodiumsalt 4-imidazolidinedione,1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-s dantorolenesodium 1-[[5-(4-nitrophenyl)furfurylidene]amino]imidazolidine-2,4-dione, sodium salt Dantrium(Sodiumdantrolene) 1-[5-(-4-Nitrophenyl)furfurylideneamino]imidazolidine-2,4-dione sodium 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium salt 1-[[[5-(4-Nitrophenyl)-2-furyl]methylene]amino]-3-sodio-2,4-imidazolidinedione 1-[[5-(p-Nitrophenyl)furfurylidene]amino]-3-sodiohydantoin F-440 Aantrolene Sodium Dantrolene SodiuM Salt Hydrate 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt dantrolene sodium (anhydrous) Dantrolene Sodium Salt  1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt anhydrous DantroloneSodium SODIUM DANTROLENE 1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2,4-IMIDAZOLINEDIONE SODIUM SALT 1-[[[5-(4-NITROPHENYL)-2-FURANYL]-METHYLENE]IMINO]2,4-IMIDAZOLIDINEDIONE SODIUM SALT 1-[(5-[P-NITROPHENYL]FURFURYLIDENE)-AMINO]HYDANTOIN SODIUM SALT DANTRIUM DANTROLENE NA sodium 1-[[5-(4-nitrophenyl)-2-furanyl]methylideneamino]imidazolidine-2,4-dione dantrolene sodium price Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem DantroleneSodiumSaltHydrate> antrolenesodium(anhydrous) Dantrolene sodium salt USP/EP/BP Dantrolene, sodium s Sodium 3-(((5-(4-nitrophenyl)furan-2-yl)methylene)amino)-2,5-dioxoimidazolidin-1-ide Dantrolene sodium salt hydrateQ: What is Dantrolene sodium salt hydrate Q: What is the CAS Number of Dantrolene sodium salt hydrate Q: What is the storage condition of Dantrolene sodium salt hydrate Q: What are the applications of Dantrolene sodium salt hydrate 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-99-THIOSEMICARBAZIDE 14663-23-1 4663-23-1 C15H10N4NaO5 C14H9N4O5Na C14H10N4NaO5 C14H9N4NaO5 C14H9N4NaO5xH2O Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant. Intracellular Calcium Regulators Intracellular Calcium Signaling Cell Signaling and Neuroscience Cell Biology BioChemical pharmacetical API's InsP3/Ryanodine receptor Cardiovascular APIs