ascofuranone
- CAS No.
- 38462-04-3
- Chemical Name:
- ascofuranone
- Synonyms
- Ascofuranon;Ascofranone;ascofuranone;(-)-Ascofuranone;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde;2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]-
- CBNumber:
- CB21312674
- Molecular Formula:
- C23H29ClO5
- Molecular Weight:
- 420.93
- MDL Number:
- MFCD01666362
- MOL File:
- 38462-04-3.mol
- MSDS File:
- SDS
| Melting point | 84 °C |
|---|---|
| Boiling point | 581.2±50.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| pka | 6.32±0.50(Predicted) |
| color | Needles from Me2CO/hexane |
| FDA UNII | I31EFB9515 |
ascofuranone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A787035 | (-)-Ascofuranone | 38462-04-3 | 1mg | $680 | 2021-12-16 | Buy |
| TRC | A787035 | (-)-Ascofuranone | 38462-04-3 | 2.5mg | $1590 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016108 | ASCOFURANONE 95.00% | 38462-04-3 | 5MG | $501.36 | 2021-12-16 | Buy |
ascofuranone Chemical Properties,Uses,Production
Uses
(-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice.
Definition
ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-).
Safety Profile
Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-.
ascofuranone Preparation Products And Raw materials
Raw materials
Preparation Products
ascofuranone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3661 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Zhejiang Huida Biotech Co., LTD | 58 |
| Zhejiang Huida Biotech Co., LTD | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| United States Biological | 58 |