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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Structure
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine structure
CAS No.
515880-75-8
Chemical Name:
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
Synonyms
DMH-4;DMH4,DMH-4;N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine;4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine;Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-
CBNumber:
CB21337701
Molecular Formula:
C24H24N4O2
Molecular Weight:
400.47
MDL Number:
MFCD18452839
MOL File:
515880-75-8.mol
Last updated:2023-09-04 15:51:00
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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Properties

Density 1.25±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL
pka 6.28±0.10(Predicted)
form powder
color off-white to brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D8696 DMH4 >99.0% (HPLC) 515880-75-8 5mg $154 2022-05-15 Buy
Cayman Chemical 27653 DMH4 515880-75-8 1mg $45 2024-03-01 Buy
Cayman Chemical 27653 DMH4 515880-75-8 25mg $437 2024-03-01 Buy
Cayman Chemical 27653 DMH4 515880-75-8 5mg $121 2024-03-01 Buy
Cayman Chemical 27653 DMH4 515880-75-8 10mg $198 2024-03-01 Buy
Product number Packaging Price Buy
D8696 5mg $154 Buy
27653 1mg $45 Buy
27653 25mg $437 Buy
27653 5mg $121 Buy
27653 10mg $198 Buy

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Chemical Properties,Uses,Production

Description

DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 μM in a cell-free assay) and a derivative of dorsomorphin . It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 μM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 μM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM).

Uses

DMH 4 is a selective VEGFR-2 inhibitor. DMH 4 displays antiangiogenic activity in vitro and in vivo.

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Preparation Products And Raw materials

Raw materials

Preparation Products

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-0755-85201366 18938635012 sales@regentsciences.com China 9293 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55827 58
BOC Sciences -- info@bocsci.com USA 0 65
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
J & K SCIENTIFIC LTD. 76
Chemsky (shanghai) International Co.,Ltd 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shenzhen Regent Biochemical Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
BOC Sciences 65

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Spectrum

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine(515880-75-8)1HNMR
4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine DMH-4 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl- DMH4,DMH-4 515880-75-8 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals