ChemicalBook
Chinese Japanese Germany Korea

1-Adamantanol

Outline Uses
1-Adamantanol
1-Adamantanol structure
CAS No.
768-95-6
Chemical Name:
1-Adamantanol
Synonyms
1-AD-OH;1-ADA-OH;1-Adamantol;ADAMANTANOL;damantol-(1);1-Adamatanol;AKOS BC-0650;1-Admantanol;1-Adamantano;1-ADAMANTANOL
CBNumber:
CB2135047
Molecular Formula:
C10H16O
Formula Weight:
152.23
MOL File:
768-95-6.mol

1-Adamantanol Properties

Melting point:
247 °C (subl.) (lit.)
Boiling point:
214.73°C (rough estimate)
Density 
0.8544 (rough estimate)
refractive index 
1.4880 (estimate)
Flash point:
240°C
storage temp. 
Sealed in dry,Room Temperature
pka
15.38±0.20(Predicted)
form 
Crystalline Powder or Needles
color 
White to off-white
Water Solubility 
Soluble in ethanol , methanol, and diethyl ether. Partly miscible in water.
Sublimation 
240 ºC
BRN 
1903952
InChIKey
VLLNJDMHDJRNFK-UHFFFAOYSA-N
CAS DataBase Reference
768-95-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
P9J0B0C8ZB
NIST Chemistry Reference
1-Adamantanol(768-95-6)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  AU4980000
Hazard Note  Irritant
HS Code  29061900

1-Adamantanol price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 130346 1-Adamantanol ReagentPlus , 99% 768-95-6 5g $27 2021-03-22 Buy
Sigma-Aldrich 130346 1-Adamantanol ReagentPlus , 99% 768-95-6 25g $69.5 2021-03-22 Buy
TCI Chemical A0939 1-Adamantanol >98.0%(GC) 768-95-6 25g $83 2021-03-22 Buy
TCI Chemical A0939 1-Adamantanol >98.0%(GC) 768-95-6 250g $416 2021-03-22 Buy
Alfa Aesar A10209 1-Adamantanol, 99% 768-95-6 50g $127 2020-06-24 Buy

1-Adamantanol Chemical Properties,Uses,Production

Outline

1-adamantanol is also known as 1-hydroxide adamantane, 1-tricyclo [3.3.1.1 (3.7)] decyl alcohol. At room temperature, it is white crystalline powder with the melting point higher than 240 ℃. It is soluble in organic solvents and insoluble in water with sublimation property. It can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to generate 1-adamantane acetic acid. 1-adamantyl acetate can further undergo bromination and hydrolyzed into 3-hydroxy-1-adamantyl acetate which can further react with vinylidene chloride to give 1, 3-adamantane di-acetic acid.
1-adamantanol can have Friedel-Crafts alkylation reaction acetanilide in the 98% sulfuric acid medium at room temperature for direct synthesis of 1, 3-bis (4-acetylamino-phenyl) adamantane which can undergo alkaline hydrolysis for synthesis of 1, 3 bis (4-aniline) adamantane. The synthetic route has many advantages including relative high reaction yield and easy purification, etc., therefore greatly facilitating the synthesis of 1, 3-diaryl adamantane derivatives.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

1-adamantanol can be used as the intermediate for synthesis of adamantanes derivatives. For example, it can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to give 1-adamantane acetic acid.

Chemical Properties

white to off-white crystalline powder or needles

Synthesis Reference(s)

Synthetic Communications, 19, p. 2061, 1989 DOI: 10.1080/00397918908052598
Tetrahedron Letters, 28, p. 1941, 1987 DOI: 10.1016/S0040-4039(00)96015-5

Purification Methods

If 2-adamantanol is a suspected impurity, then dissolve the substance (10g) in acetone (100mL) and add Jones's reagent [CrO3 (10.3g) in H2O (30mL)], then conc H2SO4 (8.7mL) is added dropwise (turns green in colour) until excess reagent is present (slight red colour). Stir overnight, decant the acetone solution from the Cr salts and adamantan-2-one, dry (Na2SO4) and evaporate to dryness. The residue (ca 7g) is chromatographed through Al2O3 (250g) and washed with 50% *benzene/pet ether (b 40-60o), then 100% Et2O (to remove any adamantan-2-one present) and the 1-adamantanol is then eluted with 5% MeOH in Et2O. The eluate is evaporated, and the residue is recrystallised from pet ether (b 30-60o) at -70o, m 287.2-288.5o. It also crystallises from MeOH and can be sublimed in vacuo. It has characteristic IR, max 3640, 1114, 1086, 982 and 930cm-1. [Schleyer & Nicholas J Am Chem Soc 83 182 1961.] [Beilstein 6 IV 391.] Alternatively, if free from the 2-isomer, dissolve it in tetrahydrofuran, dilute with H2O to precipitate the alcohol. Collect, dry and sublime it in a vacuum at 130o. [Stetter et al. Chem Ber 92 1629 1959.]

1-Adamantanol Preparation Products And Raw materials

Raw materials

Preparation Products


1-Adamantanol Suppliers

Global( 350)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu Yuanda Chemical Co., Ltd
86-28-85356300 / 18980937689
86-28-85356300 sales@ydachem.com CHINA 94 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from 1-Adamantanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 1-Adamantanol
768-95-6
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-13 1-Adamantanol
768-95-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 1-Adamantanol
768-95-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

1-Adamantanol Spectrum


768-95-6(1-Adamantanol)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved