Amyloid β-Peptide (1-42) (human)
- CAS No.
- 107761-42-2
- Chemical Name:
- Amyloid β-Peptide (1-42) (human)
- Synonyms
- TB500;Soy Peptide Powder;DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA;DA-42;soy peptide;β-Amyloid-42;Soy Oligopeptides;Amyloid β Protein Fragment 1-42;Amyloid β-Peptide (1-42) (human);Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
- CBNumber:
- CB2139797
- Molecular Formula:
- C203H311N55O60S1
- Molecular Weight:
- 4514.04
- MDL Number:
- MFCD00163049
- MOL File:
- 107761-42-2.mol
- MSDS File:
- SDS
storage temp. | -20°C |
---|---|
solubility | Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO. |
form | Lyophilized |
color | Lyophilized White |
Sequence | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH |
InChIKey | XPESWQNHKICWDY-QYFPAAMGSA-N |
CAS DataBase Reference | 107761-42-2(CAS DataBase Reference) |
FDA UNII | 042A8N37WH |
SAFETY
Risk and Safety Statements
Safety Statements | 24/25 |
---|---|
WGK Germany | 3 |
HS Code | 29332900 |
Amyloid β-Peptide (1-42) (human) price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A9810 | Amyloid β Protein Fragment 1-42 | 107761-42-2 | 0.1mg | $299 | 2024-03-01 | Buy |
Sigma-Aldrich | 171596 | β-Amyloid Peptide (1-42), Rat | 107761-42-2 | 250μg | $445 | 2024-03-01 | Buy |
Alfa Aesar | J66387 | Amyloid beta (1-42), human | 107761-42-2 | 0.5mg | $354 | 2023-06-20 | Buy |
Alfa Aesar | J66387 | Amyloid beta (1-42), human | 107761-42-2 | 1mg | $564 | 2023-06-20 | Buy |
Cayman Chemical | 20574 | Amyloid-β (1-42) Peptide ≥96% | 107761-42-2 | 1mg | $276 | 2021-12-16 | Buy |
Amyloid β-Peptide (1-42) (human) Chemical Properties,Uses,Production
Chemical Properties
Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.
Uses
Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.
Application
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.
General Description
Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.
Biochem/physiol Actions
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.
storage
-20°C
References
[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.
Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2534 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 491 | 58 |
Hebei Xunou new energy Technology Co., LTD | +86-17531957005; +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
Zhuzhou New Peptides Tech Co.,Ltd. | +86-18073326374 +86-18073326374 | sales@goodpeptides.com | China | 145 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | admin@oudaxin.com | China | 114 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 | qt01@qiangtaipharm.com | China | 84 | 58 |
CONTIDE BIOTECH CO.,LTD | +44-7438349267 +44-7438349267 | xena@healthtide-api.com | China | 562 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Related Qustion
- Q:What is the difference between Aβ(1-42) and Aβ(1-40)?
- A:The only difference between Aβ42 and Aβ40 is that Aβ42 has two extra residues at the C-terminus.
- Feb 22,2024
View Lastest Price from Amyloid β-Peptide (1-42) (human) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | TB500 | US $50.00-40.00 / kit | 1kit | 99.99% | 1000 | Wuhan Cell Pharmaceutical Co., Ltd | ||
2024-09-20 | beta-Amyloid (1-42) human
107761-42-2
|
US $0.00 / G | 1G | ≥98% HPLC | 100KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-09-12 | Amyloid β-Peptide (1-42) (human)
107761-42-2
|
US $80.00-75.00 / box | 1box | 99.9+ | 2000box | Strong peptide cross-border e-commerce Co. LTD |
- TB500
- US $50.00-40.00 / kit
- 99.99%
- Wuhan Cell Pharmaceutical Co., Ltd
- beta-Amyloid (1-42) human
107761-42-2
- US $0.00 / G
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Amyloid β-Peptide (1-42) (human)
107761-42-2
- US $80.00-75.00 / box
- 99.9+
- Strong peptide cross-border e-commerce Co. LTD
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