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Alendronate sodium

CAS No.
121268-17-5
Chemical Name:
Alendronate sodium
Synonyms
ALENDRONATE SODIUM TRIHYDRATE;Fosamax;Sodium alendronate trihydrate;MK-217;Bifosa;NeoBon;ADRONAT;Fosalan;Fosamsx;Alendros
CBNumber:
CB2145121
Molecular Formula:
C4H13NO7P2.3H2O.Na
Molecular Weight:
326.13
MDL Number:
MFCD01748233
MOL File:
121268-17-5.mol
Last updated:2023-08-18 13:05:06

Alendronate sodium Properties

Melting point 245°C
storage temp. -20°C
solubility water, double-distilled: 10 mg/mL
form solid
color white
Water Solubility Soluble in water at 10mg/ml
Merck 14,229
Stability Store in freezer
InChIKey NKENDYHBVCKCNL-UHFFFAOYSA-M
CAS DataBase Reference 121268-17-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms alendronate sodium; Fosamax
FDA UNII 2UY4M2U3RA
NCI Drug Dictionary alendronate sodium

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-60
WGK Germany  3
RTECS  SZ6523500
HS Code  29310095
NFPA 704
0
3 0

Alendronate sodium price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 126855 Alendronate, Sodium Salt 121268-17-5 100mg $239 2024-03-01 Buy
Sigma-Aldrich 1012780 Alendronate sodium United States Pharmacopeia (USP) Reference Standard 121268-17-5 200mg $436 2024-03-01 Buy
TCI Chemical A2456 Alendronate Sodium Trihydrate >97.0%(T) 121268-17-5 5g $89 2024-03-01 Buy
TCI Chemical A2456 Alendronate Sodium Trihydrate >97.0%(T) 121268-17-5 25g $267 2024-03-01 Buy
Alfa Aesar J61397 Alendronate sodium trihydrate 97% 121268-17-5 1g $38.65 2024-03-01 Buy
Product number Packaging Price Buy
126855 100mg $239 Buy
1012780 200mg $436 Buy
A2456 5g $89 Buy
A2456 25g $267 Buy
J61397 1g $38.65 Buy

Alendronate sodium Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.

Uses

Inhibits bone resorption and increases bone density.

Uses

dopamine receptor agonist, antiParkinsonian

Uses

A bisphosphonate used as a bone reabsoption inhibitor

Definition

ChEBI: A hydride that is the trihydrate of alendronate sodium

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

brand name

Fosamax (Merck).

Therapeutic Function

Antiosteoporotic

General Description

Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.

Biochem/physiol Actions

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

56-12-2
121268-17-5
Synthesis of Alendronate sodium from 4-Aminobutyric acid

Alendronate sodium Preparation Products And Raw materials

Global( 522)Suppliers
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Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
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+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58

View Lastest Price from Alendronate sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Alendronate sodium pictures 2023-09-06 Alendronate sodium
121268-17-5
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
Alendronate sodium pictures 2023-08-18 Alendronate sodium
121268-17-5
US $50.00 / kg 1kg 99% 1000tons Henan Bao Enluo International TradeCo.,LTD
Alendronate sodium pictures 2023-08-12 Alendronate sodium
121268-17-5
US $10.00 / KG 1KG 99% 5000000kg Hebei Mojin Biotechnology Co., Ltd
  • Alendronate sodium pictures
  • Alendronate sodium
    121268-17-5
  • US $50.00 / kg
  • 99%
  • Henan Bao Enluo International TradeCo.,LTD

Alendronate sodium Spectrum

SodiuM Alendronate Hydrate Alendronate SodiuM API Alendronic Acid Monosodium Salt (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate G-704650 Adronat 1,1-DiMethyl-3-Methylthio ethylaMine ALENDRONATE SODIUM SALT ALENDRONATE, SODIUM SALT TRIHYDRATE ALENDRONNATE SODIUM TRIHYDRATE ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE ADRONAT 4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE MK-217 SODIUM, 4-AMINO-1-HYDROXY-1-PHOSPHONO-BUTANE-1-PHOSPHONATE TRIHYDRATE Alendros Bifosa Fosalan Monosodium alendronate NeoBon Osteovan Alendronate Monosodium Trihydrate ALENDRONATE SODIUM 3-HYDRATE Alendronate Sodium (Fosamax) (4-amino-1-hydroxybutylidene)bis-phosphonicacimonosodiumsalt aminohydroxybutylidenebiphosphonatemonosodiumsalt monosodium(4-amino-1-hydroxybutylidene)bisphosphonate sodium(4-amino-1-hydroxybutylidene)bisphosphonate MK-217, G-704650, Adronat ALENDRONATESODIUM,EP 4-Amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium salt Alendronate sodium Alendronic acid monosodium salt Alendronate MonosodiuM salt trihydrate EP P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, sodium salt, hydrate (1:1:3) Monosodium salt trihydrate G-704650 Fosamsx 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217 Alendronate trihydrate sodium P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonicacidmonosodiumsalt Alendronate Sodium (200 mg) SodiuM Alendronate, EP MonosodiuM Alendronate Trihydrate P,P'-(4-AMino-1-hydroxybutylidene)bisphosphonic Acid SodiuM Salt Hydrate Alendronic acid monosodium salt trihydrate - USP Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem Alendronate sodium hydrate (MK 217) Alendronate Sodium Salt Trihydrate, 97.0+ % (HPLC) Alendronate Sodium Trihydrate> Sodium alendronate for system suitability CRS Sodium alendronate trihydrate CRS Alendronate Sodium RS sodium (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonate) (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate Alendronate sodium trihydrate, ≥97% Sodium alendronate trihydrate (Y0001727)Q: What is Sodium alendronate trihydrate (Y0001727) Q: What is the CAS Number of Sodium alendronate trihydrate (Y0001727) Alendronate sodium trihydrateQ: What is Alendronate sodium trihydrate Q: What is the CAS Number of Alendronate sodium trihydrate Q: What is the storage condition of Alendronate sodium trihydrate Alendronate Sodium (1012780)