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Alendronate sodium

Alendronate sodium
Alendronate sodium structure
CAS No.
121268-17-5
Chemical Name:
Alendronate sodium
Synonyms
MK-217;Bifosa;NeoBon;Fosamsx;ADRONAT;Fosalan;Fosamax;G-704650;Alendros;Osteovan
CBNumber:
CB2145121
Molecular Formula:
C4H12NO7P2.Na.3H2O
Formula Weight:
325.12
MOL File:
121268-17-5.mol

Alendronate sodium Properties

Melting point:
245°C
storage temp. 
-20°C
solubility 
water, double-distilled: 10 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water at 10mg/ml
Merck 
14,229
Stability:
Store in freezer
InChIKey
NKENDYHBVCKCNL-UHFFFAOYSA-M
CAS DataBase Reference
121268-17-5(CAS DataBase Reference)
FDA UNII
2UY4M2U3RA
NCI Dictionary of Cancer Terms
alendronate sodium; Fosamax
NCI Drug Dictionary
alendronate sodium
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330-P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-60
WGK Germany  3
RTECS  SZ6523500
HS Code  29310095

Alendronate sodium price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 126855 Alendronate, Sodium Salt 121268-17-5 100mg $185 2021-03-22 Buy
Sigma-Aldrich Y0001727 Sodium alendronate trihydrate European Pharmacopoeia (EP) Reference Standard 121268-17-5 $190 2021-03-22 Buy
Sigma-Aldrich 1012780 Alendronate sodium United States Pharmacopeia (USP) Reference Standard 121268-17-5 200mg $366 2021-03-22 Buy
TCI Chemical A2456 Alendronate Sodium Trihydrate >97.0%(T) 121268-17-5 5g $84 2021-03-22 Buy
TCI Chemical A2456 Alendronate Sodium Trihydrate >97.0%(T) 121268-17-5 25g $266 2021-03-22 Buy

Alendronate sodium Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Originator

Adronat ,Neopharmed ,Italy

Uses

A bisphosphonate used as a bone reabsoption inhibitor

Uses

dopamine receptor agonist, antiParkinsonian

Uses

Inhibits bone resorption and increases bone density.

Definition

ChEBI: A hydride that is the trihydrate of alendronate sodium

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

brand name

Fosamax (Merck).

Therapeutic Function

Antiosteoporotic

Alendronate sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Alendronate sodium Suppliers

Global( 374)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 cathy@hnxtchem.com CHINA 293 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Alendronate sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-29 Alendronate sodium
121268-17-5
US $0.00 / Kg/Drum 1KG 98.5%min HPLC 500kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-25 Alendronate sodium
121268-17-5
US $15.00 / KG 1KG 99 10T Henan Xiangtong Chemical Co., Ltd.
2021-07-02 Alendronate sodium
121268-17-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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