(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
![(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Structure](CAS/GIF/29734-68-7.gif)
- CAS No.
- 29734-68-7
- Chemical Name:
- (2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
- Synonyms
- DHβE hydrobromide;DHβE hydrobromide;Dihydro-b-erythroidi;-erythroidineHydrobromide;-erythroidine hydrobromide;DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE;Dihydro-2-erythroidine Hydrobromide;Dihydro-β-erythroidine hydrobromide;Dihydro-β-erythroidine hydrobromide;DIHYDRO-BETA-ERYTHROIDINE HYDROBROMIDE
- CBNumber:
- CB2145747
- Molecular Formula:
- C16H21NO3.BrH
- Molecular Weight:
- 356.25
- MDL Number:
- MFCD00153793
- MOL File:
- 29734-68-7.mol
- MSDS File:
- SDS
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Properties
| storage temp. | Desiccate at RT |
|---|---|
| solubility | ethanol: 5mg/mL |
| form | solid |
| Melting point | 219-229 °C (decomp) |
| color | white |
| FDA UNII | NS1U03GC05 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-36 |
|---|---|
| WGK Germany | 3 |
| RTECS | KF3325000 |
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2349 | Dihydro-b-erythroidinehydrobromide ≥98%(HPLC) | 29734-68-7 | 10 | $214 | 2021-12-16 | Buy |
| Tocris | 2349 | Dihydro-b-erythroidinehydrobromide ≥98%(HPLC) | 29734-68-7 | 50 | $891 | 2021-12-16 | Buy |
| TRC | D452485 | Dihydro-β-erythroidineHydrobromide | 29734-68-7 | 0.5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B7030 | Dihydro-β-erythroidinehydrobromide | 29734-68-7 | 50mg | $1284 | 2021-12-16 | Buy |
| ApexBio Technology | B7030 | Dihydro-β-erythroidinehydrobromide | 29734-68-7 | 10mg | $308 | 2021-12-16 | Buy |
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Chemical Properties,Uses,Production
Uses
Dihydro-β-erythroidine is an alkaloid isolated from the seeds of erythrina and a competitive antagonist at the nicotinic acetylcholine receptor (nAChR).
Definition
ChEBI: Dihydro-beta-erythroidine hydrobromide is a member of indoles.
Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α 4 receptor subunit (IC 50 values are 0.19 and 0.37 μ M for α 4 β 4 and α 4 β 2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo .
in vitro
dhβe has been shown to be a purely competitive antagonist of the neuronal nicotinic receptor [1].
in vivo
dhβe is able to block some of the central actions of nicotine after systemic and intrathecal administration. the mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of dhβe on nicotine receptor [2].
IC 50
1.3 μm for α2β2, 2.3 μm for α2β4, 0.41 μm for α3β2, 23.1 μm for α3β4, 0.37 μm for α4β2, and 0.19 μm for α4β4 [1]
storage
Desiccate at RT
References
[1] harvey sc, maddox fn, luetje cw. multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. j neurochem. 1996 nov;67(5):1953-9.
[2] damaj mi, welch sp, martin br. in vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice. psychopharmacology (berl). 1995 jan;117(1):67-73.
[3] murphree hb. effects in human volunteers of subparalytic doses of dihydro-beta-erythroidine. clin pharmacol ther. 1963 may-jun;4:304-10.
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
29734-68-7((2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE)Related Search:
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