PHYSOSTIGMINE SALICYLATE
- CAS No.
- 57-64-7
- Chemical Name:
- PHYSOSTIGMINE SALICYLATE
- Synonyms
- ESERINE SALICYLATE;Physostigmine-d3 salicylate;ar-44;tl-1380;CCRIS 3405;Isopto Eserine;EINECS 200-343-8;physostolsalicylate;Physostigminsalicylat;ESERINE SALICYLATE(RG)
- CBNumber:
- CB2146890
- Molecular Formula:
- C22H27N3O5
- Molecular Weight:
- 413.47
- MDL Number:
- MFCD00135659
- MOL File:
- 57-64-7.mol
| Melting point | 181-183 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml |
| pka | pKa 1.96/8.08(H2O,t =15) (Uncertain) |
| Merck | 7384 |
| BRN | 3900576 |
| InChIKey | HZOTZTANVBDFOF-DPKVYHSMNA-N |
| SMILES | C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r| |
| CAS DataBase Reference | 57-64-7(CAS DataBase Reference) |
| FDA UNII | 2046ZRO9VU |
| EPA Substance Registry System | Physostigmine salicylate (57-64-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330 | |||||||||
| Precautionary statements | P301+P310+P330-P304+P340+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28 | |||||||||
| Safety Statements | 25-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TJ2450000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2939800000 | |||||||||
| Toxicity | LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) | |||||||||
| NFPA 704 |
|
PHYSOSTIGMINE SALICYLATE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P1600000 | Physostigmine salicylate European Pharmacopoeia (EP) Reference Standard | 57-64-7 | p1600000 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1537003 | Physostigmine salicylate United States Pharmacopeia (USP) Reference Standard | 57-64-7 | 200mg | $436 | 2024-03-01 | Buy |
| TRC | P398510 | Physostigmine salicylate | 57-64-7 | 50mg | $765 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0003349 | ESERINE SALICYLATE SALT 95.00% | 57-64-7 | 1G | $2737.84 | 2021-12-16 | Buy |
| ChemScene | CS-0013051 | Physostigmine salicylate ≥99.00% | 57-64-7 | 100mg | $300 | 2021-12-16 | Buy |
PHYSOSTIGMINE SALICYLATE Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
Uses
cholinergic, anticholinesterase, miotic
Definition
ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.
brand name
Antilirium (Forest); Isopto Eserine (Alcon).
General Description
The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.
General Description
Crystal form that turns red on exposure to heat or light.
Reactivity Profile
Behaves as a weak acid in solution.
Health Hazard
PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
Fire Hazard
When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.
Safety Profile
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.
PHYSOSTIGMINE SALICYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1227 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from PHYSOSTIGMINE SALICYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-28 | PHYSOSTIGMINE SALICYLATE USP/EP/BP
57-64-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
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- PHYSOSTIGMINE SALICYLATE USP/EP/BP
57-64-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited