CASPASE-1
- CAS No.
- 122191-40-6
- Chemical Name:
- CASPASE-1
- Synonyms
- ICE;CASP-1;IL-1BC;CASPASE-1;ICE 1B HUMAN;P45) USP/EP/BP;CASPASE 1 HUMAN;IL-1 β converting enzyme;IL-1BETA CONVERTING ENZYME;Interleukin-1β-Converting Enzyme
- CBNumber:
- CB2155407
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02677921
- MOL File:
- Mol file
| storage temp. | −70°C |
|---|---|
| FDA 21 CFR | 1250.43 |
| NCI Dictionary of Cancer Terms | ICE |
| FDA UNII | GTI4HE0N2F |
CASPASE-1 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4503272 | Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit affinity isolated antibody | 122191-40-6 | 100μG | $506 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB4503271 | Anti-CASP1, C-Terminal antibody produced in rabbit affinity isolated antibody | 122191-40-6 | 100μG | $506 | 2024-03-01 | Buy |
| Sigma-Aldrich | 218783 | Caspase-1, Human, Recombinant, E. coli | 122191-40-6 | 3000u | $604 | 2024-03-01 | Buy |
| Sigma-Aldrich | C5482 | Caspase 1 human recombinant, expressed in E. coli, ≥5000?units/mg protein | 25UNITS | $426 | 2023-06-20 | Buy | |
| Sigma-Aldrich | C5482 | Caspase 1 human recombinant, expressed in E. coli, ≥5000?units/mg protein | 100UNITS | $885 | 2023-06-20 | Buy |
CASPASE-1 Chemical Properties,Uses,Production
Uses
Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocytic?cells (THP1).
General Description
Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer.
Biochem/physiol Actions
Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening.
CASPASE-1 Preparation Products And Raw materials
Raw materials
Preparation Products
CASPASE-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 6633 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Creative Enzymes | 58 |
| Dideu Industries Group Limited | 58 |
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 58 |
| United States Biological | 58 |