(S)-3-aminopiperidin-2-one Hydrochloride
- CAS No.
- 42538-31-8
- Chemical Name:
- (S)-3-aminopiperidin-2-one Hydrochloride
- Synonyms
- Ornithine aspartate-1;Ornithine-1,5-LactaM HCl;Aspartic acid Impurity B;3-(S)-Amino-piperidin-2-one L-Ornithine lactam (hydrochloride);(S)-3-AMino-2-piperidone Hydrochloride;(S)-3-aminopiperidin-2-one Hydrochloride;3-(S)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE;(3S)-3-Amino-2-piperidinone Hydrochloride;(S)-3-AMino-2-piperidone hydrochloride 95%
- CBNumber:
- CB21562273
- Molecular Formula:
- C5H11ClN2O
- Molecular Weight:
- 150.61
- MDL Number:
- MFCD09259964
- MOL File:
- 42538-31-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(S)-3-aminopiperidin-2-one Hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 757993 | (S)-3-Amino-2-piperidone hydrochloride 95% | 42538-31-8 | 500mg | $80.1 | 2022-05-15 | Buy |
| TRC | A627940 | (S)-3-Aminopiperidin-2-oneHydrochloride | 42538-31-8 | 2.5g | $845 | 2021-12-16 | Buy |
| TRC | A627940 | (S)-3-Aminopiperidin-2-oneHydrochloride | 42538-31-8 | 50mg | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 132433 | (S)-3-Aminopiperidin-2-onehydrochloride 97% | 42538-31-8 | 5g | $475 | 2021-12-16 | Buy |
| AK Scientific | 5871AB | (S)-3-Aminopiperidin-2-onehydrochloride | 42538-31-8 | 250mg | $124 | 2021-12-16 | Buy |
(S)-3-aminopiperidin-2-one Hydrochloride Chemical Properties,Uses,Production
Uses
(S)-3-Amino-2-piperidone hydrochloride can be used as a building block for the synthesis of 5-hydroxy-2-[(3S)-2-oxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione by reacting with 4-hydroxyphthalic anhydride. It is also used to prepare eukaryotic signaling peptide glorin and its synthetic analog glorinamide.
Synthesis
3184-13-2
42538-31-8
General procedure for the synthesis of 3-(S)-amino-2-piperidone hydrochloride from L-ornithine hydrochloride: trimethylchlorosilane (2.8 mL, 23 mmol, 4 eq.) was slowly added to L-ornithine hydrochloride (1.0 g, 6.0 mmol, 1 eq.), followed by anhydrous methanol (20 mL). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solution was cooled to 0 °C and an ethanol solution of 21% (w/w) sodium ethanol (42 mmol, 17 mL) was added dropwise. after 5 min, the reaction system was slowly warmed up to room temperature and stirring was continued for 30 min. The pH of the reaction solution was adjusted with aqueous 6N HCl to 7. The neutralized solution was filtered and the filtrate was concentrated under reduced pressure. The crude product was concentrated again under reduced pressure to remove salts by dissolving in isopropanol and filtering to remove insoluble matter. Finally, the crude product was purified by silica gel fast column chromatography (eluent: 30% methanol/dichloromethane) to afford the target compound 3-(S)-amino-2-piperidone hydrochloride as a hygroscopic light yellow solid.
References
[1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 247 - 250
[2] Enantiomer, 2001, vol. 6, # 5, p. 275 - 279
[3] Chemistry Letters, 1981, p. 1691 - 1694
[4] Organic Process Research and Development, 2005, vol. 9, # 5, p. 570 - 576
(S)-3-aminopiperidin-2-one Hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
| Wuhan Konberd Biotech Co., Ltd | +undefined18986093962 | admin@konberdbio.com | China | 1379 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| Weifang Wehibest Supply Chain Co.,Ltd | +8613583620690 | hotspotbiotech@163.com | China | 926 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
View Lastest Price from (S)-3-aminopiperidin-2-one Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
|
 |
2021-07-02 | (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
|
US $1.00 / KG | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (S)-3-aminopiperidin-2-one Hydrochloride
42538-31-8
- US $1.00 / KG
- 99.0%
- Career Henan Chemical Co
