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PBP

Abstract Treatment for vitiligo How to use Category Toxic grading Acute toxicity Stimulate data Flammability hazard characteristics Storage Extinguishing agent References
PBP
PBP structure
CAS No.
103-16-2
Chemical Name:
PBP
Synonyms
PBP;PEBP;RKIP;Alba;PEBP1;Pigmex;HCNPpp;Agerite;Enzoquin;Benoquin
CBNumber:
CB2156828
Molecular Formula:
C13H12O2
Formula Weight:
200.23
MOL File:
103-16-2.mol

PBP Properties

Melting point:
119-120 °C (lit.)
Boiling point:
297.96°C (rough estimate)
Density 
1,26 g/cm3
refractive index 
1.5906 (estimate)
storage temp. 
Store below +30°C.
pka
10.29±0.15(Predicted)
form 
Powder, Crystals, and/or Chunks
color 
Off-white to beige to brown
Water Solubility 
slightly soluble
Merck 
14,6248
BRN 
1958305
InChIKey
VYQNWZOUAUKGHI-UHFFFAOYSA-N
CAS DataBase Reference
103-16-2(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
HYDROQUINONE MONOBENZYL ETHER
FDA 21 CFR
175.105; 177.2600
FDA UNII
9L2KA76MG5
NCI Drug Dictionary
Benoquin
ATC code
D11AX13
NIST Chemistry Reference
Monobenzone(103-16-2)
EPA Substance Registry System
Monobenzone (103-16-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P261-P264-P272-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P501-P280-P305+P351+P338-P280a-P321-P333+P313-P501a
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  24/25-26-37
WGK Germany  2
RTECS  SJ7700000
Hazard Note  Irritant
TSCA  Yes
HS Code  29095090
Toxicity LD50 i.p. in mice: >600 mg/kg (Takahashi)

PBP price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 158348 4-(Benzyloxy)phenol 98% 103-16-2 25g $37.5 2021-03-22 Buy
Sigma-Aldrich 8.41834 4-Benzyloxyphenol for synthesis 103-16-2 25 g $43.66 2021-03-22 Buy
Sigma-Aldrich 1445506 Monobenzone United States Pharmacopeia (USP) Reference Standard 103-16-2 200mg $366 2021-03-22 Buy
TCI Chemical B1104 4-(Benzyloxy)phenol >99.0%(GC) 103-16-2 25g $37 2021-03-22 Buy
TCI Chemical B1104 4-(Benzyloxy)phenol >99.0%(GC) 103-16-2 100g $101 2021-03-22 Buy

PBP Chemical Properties,Uses,Production

Abstract

Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.
The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.

Treatment for vitiligo

Monobenzone may cause destruction of melanocytes and permanent depigmentation.Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes.This function enables it treat the uneven appearance of the skin due to a loss of skin color (vitiligo). It works by permanently removing color from normal skin located around skin with vitiligo. This will help to make the appearance of the skin more even. 
What calls for special attention is that: Do not use this drug to treat other skin discoloration problems ("sun spots," "age spots," freckles, skin discoloration caused by hormone medicine, perfumes, pregnancy, or skin trauma). Monobenzone is not a mild cosmetic bleach. Because it causes a permanent discoloration of the skin, it may not be the right treatment for these other skin conditions.
Besides, Monobenzone is also being considered for the treatment of Melanoma.

How to use

This medication is for use on the skin only. Apply a thin layer of the medication to normal-colored skin, usually 2-3 times daily or as directed by your doctor. Avoid getting this product in your eyes or on the inside of your nose or mouth. If you do get this medication in those areas, flush with plenty of water.After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight, tanning booths, and sunlamps. Always use a sunscreen of SPF 15 or greater, and wear protective clothing when outdoors.It may take up to 4 months before the full benefit of this drug takes effect. Once the desired skin color is achieved, this medication is applied only as needed to maintain your new skin color (usually 2 times a week).Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Inform your doctor if your condition persists or worsens after 4 months.
You should not use this medication if you are allergic to monobenzone. Do not use monobenzone on any areas that are not affected by vitiligo.

Category

Toxic substance

Toxic grading

Moderate toxicity

Acute toxicity

Abdomen-rat LD50: 4500 mg/kg

Stimulate data

Skin-guinea pigs 5%/48 hours,  mild grade.

Flammability hazard characteristics

The drug is combustible, and combustion releases stimulus smoke.

Storage

Ventilated warehouse, low temperature, dry; Separated from food raw materials.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, mist water.

References

http://www.medicinenet.com/monobenzone-topical/article.htm
https://www.drugs.com/pro/benoquin.html
http://www.emedicinehealth.com/drug-monobenzone_topical/article_em.htm#important

Description

May cause depigmentation

Chemical Properties

cream to beige-light brownish crystals or

Uses

PBP is used as antiinflammatory, antisecretory, antiulcer.

Uses

Hydroquinone monobenzyl ether is an antidegradant added to rubber products; inhibitor in acrylic resins.

Indications

Monobenzone (Benoquin) potently inhibits melanin production and destroys melanocytes. Like hydroquinone, monobenzone was originally introduced for the topical treatment of disorders of excess melanin pigmentation, including melasma. It is now used only to permanently depigment the remaining normally pigmented skin in patients with extensive vitiligo. Irritant and allergic contact dermatitis are common side effects.

Definition

ChEBI: The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.

brand name

Benoquin (Valeant).

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 5129, 1992 DOI: 10.1016/S0040-4039(00)61209-1

Purification Methods

Crystallise it from EtOH or H2O, and dry (P2O5) under vacuum. [Walter et al. J Am Chem Soc 108 5210 1986, Beilstein 6 IV 5778.]

PBP Preparation Products And Raw materials

Raw materials

Preparation Products


PBP Suppliers

Global( 502)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Dumi Biotechnology Co.,ltd
17172178855 +8617172178855
aimee@chinadumi.com CHINA 241 58
Hefei Hirisun Pharmatech Co., Ltd
86-15056975894
86-0551-62678551 shawn@hirisunpharm.com CHINA 9927 58
Wuhan Shuokang Biological Technology Co.,Ltd
+8615927270571 +86-86-02787366298
tianyi@skbiology.cn CHINA 296 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55

Related articles


View Lastest Price from PBP manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 monobenzone / 4-Benzyloxyphenol Bree
103-16-2
US $1.00 / KG 100g 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-12-07 4-Benzyloxyphenol / monobenzone
103-16-2
US $1.00 / KG 10g 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-12-07 PBP 4-Benzyloxyphenol
103-16-2
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd

PBP Spectrum


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