BOC-GLYCINE TERT-BUTYL ESTER
- CAS No.
- 111652-20-1
- Chemical Name:
- BOC-GLYCINE TERT-BUTYL ESTER
- Synonyms
- N-Boc-gL;BOC-GLY-OTBU;N-BOC-Gly-OtBu;Boc-Gly-Ot<;Boc-Gly-Otbu-OH;Boc-Gly-OtBu, ≥98%;Boc-Gly-OtBu;BOC-GLYCINE T-BUTYL ESTER;BOC-GLYCINE TERT-BUTYL ESTER;(Tert-Butoxy)Carbonyl Gly-OtBu
- CBNumber:
- CB2157582
- Molecular Formula:
- C11H21NO4
- Molecular Weight:
- 231.29
- MDL Number:
- MFCD00191866
- MOL File:
- 111652-20-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-Gly-OtBu 99% | 423297 | 5g | $134 |
| N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | B4156 | 1g | $22 |
| N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | B4156 | 5g | $54 |
| Boc-glycine tert-butyl ester | 265310 | 1g | $358 |
| Boc-Gly-OtBu | B656140 | 10mg | $45 |
| More product size | |||
| Melting point | 66-68 °C(lit.) |
|---|---|
| Boiling point | 306.0±25.0 °C(Predicted) |
| Density | 1.023 |
| storage temp. | 2-8°C |
| solubility | very soluble in Methanol |
| form | powder to crystal |
| pka | 11.06±0.46(Predicted) |
| color | White to Almost white |
| Water Solubility | 1.05g/L at 20℃ |
| BRN | 5002580 |
| Major Application | peptide synthesis |
| InChI | 1S/C11H21NO4/c1-10(2,3)15-8(13)7-12-9(14)16-11(4,5)6/h7H2,1-6H3,(H,12,14) |
| InChIKey | ZDKFMHKWZATBMR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CNC(=O)OC(C)(C)C |
| LogP | 2.21 at 25℃ |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H401-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-51 | |||||||||
| Safety Statements | 20/21-29/56 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29241990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
BOC-GLYCINE TERT-BUTYL ESTER price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 423297 | Boc-Gly-OtBu 99% | 111652-20-1 | 5g | $134 | 2023-06-20 | Buy |
| TCI Chemical | B4156 | N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | 111652-20-1 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | B4156 | N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | 111652-20-1 | 5g | $54 | 2026-04-30 | Buy |
| Usbiological | 265310 | Boc-glycine tert-butyl ester | 111652-20-1 | 1g | $358 | 2021-12-16 | Buy |
| TRC | B656140 | Boc-Gly-OtBu | 111652-20-1 | 10mg | $45 | 2021-12-16 | Buy |
BOC-GLYCINE TERT-BUTYL ESTER Chemical Properties,Uses,Production
Chemical Properties
Whtie powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
27532-96-3
111652-20-1
Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis.
References
[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298
BOC-GLYCINE TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1098 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from BOC-GLYCINE TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | Boc-Gly-OtBU
111652-20-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-04-04 | Boc-Gly-OtBu
111652-20-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-13 | Boc-Gly-OtBu
111652-20-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Boc-Gly-OtBU
111652-20-1
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-Gly-OtBu
111652-20-1
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Boc-Gly-OtBu
111652-20-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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